EC - 3(or 17)α-hydroxysteroid dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
3(or 17)α-hydroxysteroid dehydrogenase
Other name:
3(17)α-hydroxysteroid dehydrogenase
Systematic name:
3(or 17)α-hydroxysteroid:NAD(P)+ oxidoreductase



Acts on the 3α-hydroxy group of androgens of the 5α-androstane series; and also, more slowly, on the 17α-hydroxy group of both androgenic and estrogenic substrates (cf. EC 3(or 17)β-hydroxysteroid dehydrogenase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047023
CAS Registry Number: 83294-77-3


  1. Lau, P.C.K., Layne, D.S. and Williamson, D.G.
    A 3(17)α-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme.
    J. Biol. Chem. 257: 9444-9449 (1982). [PMID: 6955302]
  2. Lau, P.C.K., Layne, D.S. and Williamson, D.G.
    Comparison of the multiple forms of the soluble 3(17)α-hydroxysteroid dehydrogenases of female rabbit kidney and liver.
    J. Biol. Chem. 257: 9450-9456 (1982). [PMID: 6955303]

[EC created 1986]