EC 22.214.171.124 - Tropinone reductase I
IntEnz Enzyme Nomenclature
tropinone reductase [ambiguous]
18357 [IUBMB]NADP+NADP(+)Name origin: UniProt - CHECKED (C)Formula: C21H25N7O17P3
Charge: -3ChEBI compound status: CHECKED (C)tropinetropineName origin: UniProt - CHECKED (C)Formula: C8H16NO
Charge: 1ChEBI compound status: CHECKED (C)<?>H+H(+)Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)NADPHNADPHName origin: UniProt - CHECKED (C)Formula: C21H26N7O17P3
Charge: -4ChEBI compound status: CHECKED (C)
Also oxidizes other tropan-3α-ols, but not the corresponding β-derivatives . This enzyme along with EC 126.96.36.199, tropinone reductase II, represents a branch point in tropane alkaloid metabolism . Tropine (the product of EC 188.8.131.52) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 184.108.40.206) is the first specific metabolite on the pathway to the calystegines . Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific .
Links to other databases
Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium.Planta Med. 44: 227-230 (1982).
Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia.Phytochemistry 30: 801-805 (1991).
Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.Proc. Natl. Acad. Sci. USA 90: 9591-9595 (1993). [PMID: 8415746]
Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism.Phytochemistry 67: 327-337 (2006). [PMID: 16426652]
[EC 220.127.116.11 created 1984, modified 2007]