EC 1.1.1.184 - Carbonyl reductase (NADPH)

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IntEnz Enzyme Nomenclature
EC 1.1.1.184

Names

Accepted name:
carbonyl reductase (NADPH)
Other names:
ALR3
NADPH2-dependent carbonyl reductase
aldehyde reductase 1
carbonyl reductase
nonspecific NADPH-dependent carbonyl reductase
prostaglandin 9-ketoreductase
xenobiotic ketone reductase
Systematic name:
secondary-alcohol:NADP+ oxidoreductase

Reaction

Comments:

Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004090
CAS Registry Number: 89700-36-7
UniProtKB/Swiss-Prot: (21) [show] [UniProt]

References

  1. Ahmed, N.K., Felsted, R.L. and Bachur, N.R.
    Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers.
    Biochem. Pharmacol. 27: 2713-2719 (1978). [PMID: 31888]
  2. Lin, Y.M. and Jarabak, J.
    Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition.
    Biochem. Biophys. Res. Commun. 81: 1227-1234 (1978). [PMID: 666816]
  3. Wermuth, B.
    Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.
    J. Biol. Chem. 256: 1206-1213 (1981). [PMID: 7005231]

[EC 1.1.1.184 created 1983]