EC 1.1.1.159 - 7α-hydroxysteroid dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.1.1.159

Names

Accepted name:
7α-hydroxysteroid dehydrogenase
Other names:
7α-HSDH
7α-hydroxy steroid dehydrogenase
Systematic name:
7α-hydroxysteroid:NAD+ 7-oxidoreductase

Reaction

Comments:

Catalyses the oxidation of the 7α-hydroxy group of bile acids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008709
CAS Registry Number: 39361-64-3
UniProtKB/Swiss-Prot:

References

  1. Haslewood, E.S. and Haslewood, G.A.D.
    The specificity of a 7α-hydroxy steroid dehydrogenase from Escherichia coli.
    Biochem. J. 157: 207-210 (1976). [PMID: 786279]
  2. Macdonald, I.A. and Roach, P.D.
    Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum.
    Biochim. Biophys. Acta 665: 262-269 (1981). [PMID: 6945134]
  3. Macdonald, I.A., Williams, C.N. and Mahony, D.E.
    7α-Hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies.
    Biochim. Biophys. Acta 243-253 (1973). [PMID: 4581498]
  4. Macdonald, I.A., Williams, C.N., Mahony, D.E. and Christie, W.M.
    NAD- and NADP-dependent 7α-hydroxysteroid dehydrogenases from Bacteroides fragilis.
    Biochim. Biophys. Acta 384: 12-24 (1975). [PMID: 236764]

[EC 1.1.1.159 created 1976, modified 1980]