EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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IntEnz Enzyme Nomenclature
EC 1.1.1.141

Names

Accepted name:
15-hydroxyprostaglandin dehydrogenase (NAD+)
Other names:
11α,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase
15-OH-PGDH
15-hydroxyprostaglandin dehydrogenase
15-hydroxyprostanoic dehydrogenase
NAD-specific 15-hydroxyprostaglandin dehydrogenase
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)
PGDH
prostaglandin dehydrogenase
(5Z,13E)-(15S)-11α,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase
Systematic name:
(5Z,13E,15S)-11α,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase

Reaction

Comments:

Acts on prostaglandin E2, F and B1, but not on prostaglandin D2. cf. EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016404
CAS Registry Number: 9030-87-9
UniProtKB/Swiss-Prot:

References

  1. Änggård, E. and Samuelsson, B.
    Purification and properties of a 15-hydroxyprostaglandin dehydrogenase from swine lung. Prostaglandins and related factors.
    Ark. Kemi 25: 293-300 (1966).
  2. Braithwaite, S.S. and Jarabak, J.
    Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization.
    J. Biol. Chem. 250: 2315-2318 (1975). [PMID: 1117007]
  3. Lee, S.-C. and Levine, L.
    Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
    J. Biol. Chem. 250: 548-552 (1975). [PMID: 234431]
  4. Lee, S.-C., Pong, S.-S., Katzen, D., Wu, K.-Y. and Levine, L.
    Distribution of prostaglandin E 9-ketoreductase and types I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
    Biochemistry 14: 142-145 (1975). [PMID: 803247]

[EC 1.1.1.141 created 1972]