EC 1.1.1.133 - DTDP-4-dehydrorhamnose reductase

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IntEnz Enzyme Nomenclature
EC 1.1.1.133

Names

Accepted name:
dTDP-4-dehydrorhamnose reductase
Other names:
TDP-4-keto-rhamnose reductase
dTDP-4-keto-L-rhamnose reductase
dTDP-4-ketorhamnose reductase
thymidine diphospho-4-ketorhamnose reductase
dTDP-6-deoxy-L-mannose dehydrogenase
dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase
dTDP-6-deoxy-β-L-mannose:NADP+ 4-oxidoreductase
Systematic name:
dTDP-β-L-rhamnose:NADP+ 4-oxidoreductase

Reaction

Comments:

In the reverse direction, reduction on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyses epimerization at C-3 and C-5; the complex has been referred to as dTDP-L-rhamnose synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008831
CAS Registry Number: 37250-64-9
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Melo, A. and Glaser, L.
    The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose.
    J. Biol. Chem. 243: 1475-1478 (1968). [PMID: 4384782]

[EC 1.1.1.133 created 1972]