EC 1.1.1.127 - 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.127

Names

Accepted name:
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
Other names:
2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase
2-keto-3-deoxy-D-gluconate dehydrogenase
2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase
2-keto-3-deoxygluconate 5-dehydrogenase
Systematic name:
2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase

Reaction

Comments:

The enzyme from Pseudomonas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and E. coli is more specific for NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047001
CAS Registry Number: 37250-56-9
UniProtKB/Swiss-Prot:

References

  1. Condemine, G., Hugouvieux-Cotte-Pattat, N. and Robert-Baudouy, J.
    An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase.
    J. Gen. Microbiol. 130: 2839-2844 (1984).
  2. Preiss, J. and Ashwell, G.
    Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2,5-hexodiulosonic acid.
    J. Biol. Chem. 238: 1577-1583 (1963).

[EC 1.1.1.127 created 1972, modified 1976, modified 1989]