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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 15016378

Journal: Cell (0092-8674)

Year of Publication: 2004

Title: APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.

Author List: Miaczynska M., Christoforidis S., Giner A., Shevchenko A., Uttenweiler-Joseph S., Habermann B., Wilm M., Parton RG., Zerial M.

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
Chromatin - Epigenetic interactions resulting in chromatin modulation
Apoptosis - Interactions involving proteins with a function related to apoptosis
Synapse - Interactions of proteins with an established role in the presynapse.

Experiment (1 interaction)

Accession: EBI-1782515

Name: miaczynska-2004-1

Host organism: Homo sapiens epitheloid cervix carcinoma cells

Organism: Homo sapiens epitheloid cervix carcinoma cells

Accession: EBI-307614

Name: human-hela

Description: Homo sapiens epitheloid cervix carcinoma cells

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human
-

Interaction Detection Method: pull down

Interaction detection method: pull down
Accession: EBI-1223

Name: pull down

Description: pull down

Cross References:
Database
Identifier
Secondary identifier
Qualifier
pubmed
14755292
-
primary-reference
psi-mi
MI:0096
-
identity


Annotations:
Topic
Text
definition
A specific affinity chromatography method where a molecule of interest (bait) is bound to a column, often via an affinity tag expressed as a protein fusion (GST, HIS tag and others) or chemically linked to the bait molecule . The molecule may be expressed or synthesised and purified first, often in an heterologous system, bound to the matrix at high concentration and then challenged with a solution or cellular extract containing the candidate partner molecules. Alternatively, a multi-molecular complex may be adsorbed to the resin and the retained binding molecules subsequently identified.


Participant Identification Method: ms participant

Participant identification method: ms participant
Accession: EBI-608794

Name: ms participant

Description: Identification by mass spectrometry

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0427
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
identification by mass spectrometry.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-
-

Annotations:

Topic
Text
zerial@mpi-cbg.de
The origins of RAB5 determined from PMID:9323142
Proteins were detected by mobility on gel and further identified by Mass spectrometry.
Only protein-protein interactions
-
imex curation

Interaction

Accession: EBI-1782523

Name: rab5a-rabe1

Description: -

Type: association

Interaction type: association
Accession: EBI-1813191

Name: association

Description: association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0914
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
1A
Gamma S form of GTP complexed with RAB5 used in the interaction.

Participants (9)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
1
EBI-989053
 logo
guanosine triphosphate - GTP
Organism Details

Accession:

Name:

-
Expressed In Details

Accession:

Name:

-
bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


small molecule
Interactor type: small molecule
Accession: EBI-619656

Name: small molecule

Description: small molecule

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0328
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule not part of or directly encoded by the genome, encompasses any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity.


A
Participant: guanosine triphosphate - GTP

Participant: guanosine triphosphate - GTP

Accession: EBI-1782739

Name: EBI-989053

P
Participant: guanosine triphosphate - GTP

Participant: guanosine triphosphate - GTP

Accession: EBI-1782739

Name: EBI-989053

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: guanosine triphosphate - GTP

Participant: guanosine triphosphate - GTP

Accession: EBI-1782739

Name: EBI-989053

Stoichiometry: 0.0

F
Participant: guanosine triphosphate - GTP

Participant: guanosine triphosphate - GTP

Accession: EBI-1782739

Name: EBI-989053

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
No records found.

C
Participant: guanosine triphosphate - GTP

Participant: guanosine triphosphate - GTP

Accession: EBI-1782739

Name: EBI-989053

Confidences:

Type
Value
No records found.

2
EBI-2010692
 logo
dastyLogo
RAB5A
Ras-related protein Rab-5A
Canis familiaris (Dog)
Organism Details

Accession: EBI-49772

Name: canfa

Description: Canis familiaris (Dog)

Cross References:

Database
Identifier
Secondary identifier
Qualifier
canfa
-

Escherichia coli (strain K12)
Expressed In Details

Accession: EBI-1395259

Name: ecoli

Description: Escherichia coli (strain K12)

Cross References:

Database
Identifier
Secondary identifier
Qualifier
strain k12
-

bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: Ras-related protein Rab-5A

Participant: Ras-related protein Rab-5A

Accession: EBI-2010705

Name: EBI-2010692

P
Participant: Ras-related protein Rab-5A

Participant: Ras-related protein Rab-5A

Accession: EBI-2010705

Name: EBI-2010692

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: Ras-related protein Rab-5A

Participant: Ras-related protein Rab-5A

Accession: EBI-2010705

Name: EBI-2010692

Stoichiometry: 0.0

F
Participant: Ras-related protein Rab-5A

Participant: Ras-related protein Rab-5A

Accession: EBI-2010705

Name: EBI-2010692

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
region
  • ?-?
  • A
    Feature: EBI-2010706

    Feature: region

    Accession: EBI-2010706

    Name: region


    C
    Participant: Ras-related protein Rab-5A

    Participant: Ras-related protein Rab-5A

    Accession: EBI-2010705

    Name: EBI-2010692

    Confidences:

    Type
    Value
    No records found.

    3
    EBI-447043
     logo
    dastyLogo
    Rabaptin-5
    Rabaptin-5alpha
    Rabaptin-4

    [+5]
    Rab GTPase-binding effector protein 1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Rab GTPase-binding effector protein 1

    Participant: Rab GTPase-binding effector protein 1

    Accession: EBI-1782531

    Name: EBI-447043

    P
    Participant: Rab GTPase-binding effector protein 1

    Participant: Rab GTPase-binding effector protein 1

    Accession: EBI-1782531

    Name: EBI-447043

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Rab GTPase-binding effector protein 1

    Participant: Rab GTPase-binding effector protein 1

    Accession: EBI-1782531

    Name: EBI-447043

    Stoichiometry: 0.0

    F
    Participant: Rab GTPase-binding effector protein 1

    Participant: Rab GTPase-binding effector protein 1

    Accession: EBI-1782531

    Name: EBI-447043

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Rab GTPase-binding effector protein 1

    Participant: Rab GTPase-binding effector protein 1

    Accession: EBI-1782531

    Name: EBI-447043

    Confidences:

    Type
    Value
    No records found.

    4
    EBI-298113
     logo
    dastyLogo
    EEA1
    ZFYVE2
    Endosome-associated protein p162

    [+1]
    Early endosome antigen 1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Early endosome antigen 1

    Participant: Early endosome antigen 1

    Accession: EBI-1782532

    Name: EBI-298113

    P
    Participant: Early endosome antigen 1

    Participant: Early endosome antigen 1

    Accession: EBI-1782532

    Name: EBI-298113

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Early endosome antigen 1

    Participant: Early endosome antigen 1

    Accession: EBI-1782532

    Name: EBI-298113

    Stoichiometry: 0.0

    F
    Participant: Early endosome antigen 1

    Participant: Early endosome antigen 1

    Accession: EBI-1782532

    Name: EBI-298113

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Early endosome antigen 1

    Participant: Early endosome antigen 1

    Accession: EBI-1782532

    Name: EBI-298113

    Confidences:

    Type
    Value
    No records found.

    5
    EBI-1105310
     logo
    dastyLogo
    ZFYVE20
    FYVE finger-containing Rab5 effector protein rabenosyn-5
    Zinc finger FYVE domain-containing protein 20

    [+1]
    Rabenosyn-5
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Rabenosyn-5

    Participant: Rabenosyn-5

    Accession: EBI-1782533

    Name: EBI-1105310

    P
    Participant: Rabenosyn-5

    Participant: Rabenosyn-5

    Accession: EBI-1782533

    Name: EBI-1105310

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Rabenosyn-5

    Participant: Rabenosyn-5

    Accession: EBI-1782533

    Name: EBI-1105310

    Stoichiometry: 0.0

    F
    Participant: Rabenosyn-5

    Participant: Rabenosyn-5

    Accession: EBI-1782533

    Name: EBI-1105310

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Rabenosyn-5

    Participant: Rabenosyn-5

    Accession: EBI-1782533

    Name: EBI-1105310

    Confidences:

    Type
    Value
    No records found.

    6
    EBI-1782543
     logo
    dastyLogo
    VPS45
    VPS45A
    VPS45B
    Vacuolar protein sorting-associated protein 45
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Vacuolar protein sorting-associated protein 45

    Participant: Vacuolar protein sorting-associated protein 45

    Accession: EBI-1782557

    Name: EBI-1782543

    P
    Participant: Vacuolar protein sorting-associated protein 45

    Participant: Vacuolar protein sorting-associated protein 45

    Accession: EBI-1782557

    Name: EBI-1782543

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Vacuolar protein sorting-associated protein 45

    Participant: Vacuolar protein sorting-associated protein 45

    Accession: EBI-1782557

    Name: EBI-1782543

    Stoichiometry: 0.0

    F
    Participant: Vacuolar protein sorting-associated protein 45

    Participant: Vacuolar protein sorting-associated protein 45

    Accession: EBI-1782557

    Name: EBI-1782543

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Vacuolar protein sorting-associated protein 45

    Participant: Vacuolar protein sorting-associated protein 45

    Accession: EBI-1782557

    Name: EBI-1782543

    Confidences:

    Type
    Value
    No records found.

    7
    EBI-1054634
     logo
    dastyLogo
    Vesicle protein sorting 35
    Maternal-embryonic 3
    VPS35

    [+2]
    Vacuolar protein sorting-associated protein 35
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Vacuolar protein sorting-associated protein 35

    Participant: Vacuolar protein sorting-associated protein 35

    Accession: EBI-1782558

    Name: EBI-1054634

    P
    Participant: Vacuolar protein sorting-associated protein 35

    Participant: Vacuolar protein sorting-associated protein 35

    Accession: EBI-1782558

    Name: EBI-1054634

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Vacuolar protein sorting-associated protein 35

    Participant: Vacuolar protein sorting-associated protein 35

    Accession: EBI-1782558

    Name: EBI-1054634

    Stoichiometry: 0.0

    F
    Participant: Vacuolar protein sorting-associated protein 35

    Participant: Vacuolar protein sorting-associated protein 35

    Accession: EBI-1782558

    Name: EBI-1054634

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Vacuolar protein sorting-associated protein 35

    Participant: Vacuolar protein sorting-associated protein 35

    Accession: EBI-1782558

    Name: EBI-1054634

    Confidences:

    Type
    Value
    No records found.

    8
    EBI-741243
     logo
    dastyLogo
    Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
    APPL1
    APPL

    [+2]
    DCC-interacting protein 13-alpha
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DCC-interacting protein 13-alpha

    Participant: DCC-interacting protein 13-alpha

    Accession: EBI-1782559

    Name: EBI-741243

    P
    Participant: DCC-interacting protein 13-alpha

    Participant: DCC-interacting protein 13-alpha

    Accession: EBI-1782559

    Name: EBI-741243

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DCC-interacting protein 13-alpha

    Participant: DCC-interacting protein 13-alpha

    Accession: EBI-1782559

    Name: EBI-741243

    Stoichiometry: 0.0

    F
    Participant: DCC-interacting protein 13-alpha

    Participant: DCC-interacting protein 13-alpha

    Accession: EBI-1782559

    Name: EBI-741243

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DCC-interacting protein 13-alpha

    Participant: DCC-interacting protein 13-alpha

    Accession: EBI-1782559

    Name: EBI-741243

    Confidences:

    Type
    Value
    No records found.

    9
    EBI-741261
     logo
    dastyLogo
    Adapter protein containing PH domain, PTB domain and leucine zipper motif 2
    APPL2
    DIP13B
    DCC-interacting protein 13-beta
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: DCC-interacting protein 13-beta

    Participant: DCC-interacting protein 13-beta

    Accession: EBI-1782727

    Name: EBI-741261

    P
    Participant: DCC-interacting protein 13-beta

    Participant: DCC-interacting protein 13-beta

    Accession: EBI-1782727

    Name: EBI-741261

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: DCC-interacting protein 13-beta

    Participant: DCC-interacting protein 13-beta

    Accession: EBI-1782727

    Name: EBI-741261

    Stoichiometry: 0.0

    F
    Participant: DCC-interacting protein 13-beta

    Participant: DCC-interacting protein 13-beta

    Accession: EBI-1782727

    Name: EBI-741261

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: DCC-interacting protein 13-beta

    Participant: DCC-interacting protein 13-beta

    Accession: EBI-1782727

    Name: EBI-741261

    Confidences:

    Type
    Value
    No records found.


    Graphical Representation of Experimental Features