IntAct

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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.
What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. As you can see, in this tab we have grouped features under the interacting molecule types. Please note that some of these functionalities will only allow you to include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Listing the molecules involved by specific type

Clicking on the ‘List All’ present under each molecule type will open the corresponding list of molecule in the List Tab.

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:
  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.

sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.

PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

Biological Complexes

How is the number of biological complexes in IntAct obtained?

The IntAct Complex Portal is is a manually curate, encyclopaedic resource of macromolecular complexes from a number of key model organisms. All data is freely available for search and download.

Check the Complex Portal Documentation for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.
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v.4.1.3



MIQL Syntax Reference

Help: Searches in IntAct

To do a search you can use the Molecular Interaction Query Language (MIQL), which is based on Lucene's syntax.
  • Search based on exact word matches.
    • BRCA2 will not match BRCA2B
    • Association will retrieve both physical association and association
    • To retrieve all isoforms of P12345, use P12345*
  • Search will recognize ontologies and synonyms.
    • Eukaryota will retrieve all children of Eukaryota using the Uniprot taxonomy
    • affinity techniques will match affinity technology because it is affinity techniques is a synonym of affinity technology in the PSI-MI ontology
  • Default fields are used when no field is specified (simple search) :
    • Interactor id, alias
    • Interactor species
    • Interaction id
    • Publication id, first author
    • Interaction type
    • Interaction detection method
    • Interactor xrefs (GO, uniprot secondary xrefs, ...)
    • Interaction xrefs (GO, ...)
    .
    For instance, if you put 'P12345' in the simple query box, this will mean the same as identifier:P12345 OR pubid:P12345 OR pubauth:P12345 OR species:P12345 OR type:P12345 OR detmethod:P12345 OR interaction_id:P12345
  • Use OR or space ' ' to search for ANY of the terms in a field
  • Use AND if you want to search for those interactions where ALL of your terms are found
  • Use quotes (") if you look for a specific phrase (group of terms that must be searched together) or terms containing special characters that may otherwise be interpreted by our query engine (eg. ':' in a GO term)
  • Use parenthesis for complex queries (e.g. '(XXX OR YYY) AND ZZZ')
  • Wildcards (*,?) can be used between letters in a term or at the end of terms to do fuzzy queries,
    but never at the beginning of a term
  • Optionally, you can prepend a symbol in from of your term.
    • + (plus): include this term. Equivalent to AND. e.g. +P12345
    • - (minus): do not include this term. Equivalent to NOT. e.g. -P12345
    • Nothing in front of the term. Equivalent to OR. e.g. P12345

MIQL fields

You can find more information about the Molecular Interactions Query Language (MIQL) defined for PSICQUIC Here
Field NameSearches onExample
idAIdentifier AidA:P74565
idBIdentifier BidB:P74565
idIdentifiers (A or B)id:P74565
aliasAliases (A or B)alias:(KHDRBS1 OR HCK)
identifiersIdentifiers and Aliases undistinctivelyidentifier:P74565
pubauthPublication 1st author(s)pubauth:scott
pubidPublication Identifier(s)pubid:(10837477 OR 12029088)
taxidATax ID interactor A: be it the tax ID or the species nametaxidA:mouse
taxidBTax ID interactor B: be it the tax ID or species nametaxidB:9606
speciesSpecies. Tax ID A or Tax ID Bspecies:human
typeInteraction type(s)type:"physical interaction"
detmethodInteraction Detection method(s)detmethod:"two hybrid*"
interaction_idInteraction identifier(s)interaction_id:EBI-761050
pbioroleABiological role(s) interactor ApbioroleA:enzyme
pbioroleBBiological role(s) interactor BpbioroleB:enzyme
pbioroleBiological role(s) interactor (A or B)pbiorole:enzyme
ptypeAInteractor type AptypeA:protein
ptypeBInteractor type BptypeB:protein
ptypeInteractor type (A or B)ptype:protein
pxrefAInteractor xref ApxrefA:"GO:0005794"
pxrefBInteractor xref BpxrefB:"GO:0005794"
pxrefInteractor xref (A or B)pxref:"GO:0005794"
xrefInteraction xref(s)xref:"GO:0005634"
annotAnnotations/Tags Interactionannotation:"imex curation"
udateLast update of the interactionudate:[20110607 TO 20120906]
negativeBoolean value which is true if an interaction is negativenegative:true
complexComplex Expansion method(s)expansion:spoke
ftypeAFeature type(s) AftypeA:"binding site"
ftypeBFeature type(s) BftypeB:"binding site"
ftypeFeature type(s) (A or B)ftype:"binding site"
pmethodAParticipant identification method(s) ApmethodA:"western blot"
pmethodBParticipant identification method(s)) BpmethodB:"western blot"
pmethodParticipant identification method(s) (A or B)pmethod:"western blot"
stcBoolean value to know if Interactor A or B has stoichiometry information.stc:true
paramBoolean value to know if the Interaction has some parameters.param:true

IntAct fields

These field names are specific to IntAct and are not in MIQL definition for PSICQUIC.
Field NameSearches onExample
geneNameGene name for Interactor A or BgeneName:brca2
sourceSource database(s)source:mbinfo
intact-miscoreIntAct MI Score (between 0 and 1), based on number of publications, detection methods and interaction types.intact-miscore:[0.5 TO 1.0]
Search:       Show Advanced Fields »   MIQL syntax reference helpIcon
  • Free text search will look by default for interactor identifier, species, interaction id, detection method, interaction type, publication identifier or author, interactor xrefs, interaction xrefs
  • For a more specific search, use MIQL syntax or advanced search
  • Search based on exact word matches eg. BRCA2 will not match BRCA2B
  • Search for isoforms of 'P12345' by using 'P12345*'
Examples

Publication

Author List: Zhou M., Lucas DA., Chan KC., Issaq HJ., Petricoin EF., Liotta LA., Veenstra TD., Conrads TP.
Journal: Electrophoresis (0173-0835)
Year of Publication: 2004
PubMed Id: 15174051
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Apoptosis - Interactions involving proteins with a function related to apoptosis

Experiment (1 interaction)

Accession: EBI-1223534
Name: zhou-2004d-4
Host organism: Homo sapiens
Organism: Homo sapiens
Accession: EBI-1236125

Name: human-serum

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Interaction Detection Method: anti bait coip
Interaction detection method: anti bait coip
Accession: EBI-976
Name: anti bait coip
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
A specific antibody for the molecule of interest (bait) is available, this is used to generate a high affinity resin to capture the endogenous bait present in a sample.
Participant Identification Method: fingerprinting
Participant identification method: fingerprinting
Accession: EBI-70
Name: fingerprinting
Description: peptide massfingerprinting
Cross References:
Annotations:
Topic
Text
This approach leads to protein identification by matching peptide masses, as measured by mass spectrometry, to the ones calculated from in silico fragmentation of a protein sequence database. A peptide mixture from a tryptic digest is analysed by MALDI-MS (Matrix-assisted laser desorption ionization mass spectrometry). The list of peptide masses obtained by MALDI MS is automatically compared to the calculated masses of the predicted peptide fragments for each entry in the database. High mass accuracy is very important in order to obtain a statistically significant and unambiguous match This method is best applied to completely sequenced genomes and well characterised proteomes. However, depending on the data quality, proteins that are highly homologous to already characterised proteins (greater than 80 to 90% sequence identity) can also be identified. The retrieved sequence are evaluated by mass accuracy of the peptides, matching of additional peptide masses in the MALDI spectrum after accounting for common modifications such as oxidation, acrylamidation of cysteine and missed cleavages and the use of secondary information (apparent isoelectric point and molecular weight). If any ambiguity about the identification by MALDI-MS still exists, the results must verified by an other identification method. Peptide mass fingerprint is generally carried out with a MALDI-TOF (Matrix-assisted laser desorption ionization time-of-flight ) instrument but can also be achieved ESI-TOF (Electrospray Ionisation time-of-flight) or LC-MS (Liquid Chromatography-Mass Spectrometry) mass spectrometer.
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Conrads@ncifcrf.gov
In this experiment the protein G 4B Sepherose-Ab beads were washed in 10 volumes phosphate buffered saline and finally sodium phosphate (pH 7.2). The bound proteins were dissociated by boiling in 0.2% volume/volume formic acid in 50% volume/volume acetonitrile for 10 minutes. The beads were further washed with the same solution and supernatants collected and analysed.
Only protein-protein interactions
-
imex curation

Interaction

Accession: EBI-1224020
Name: alb-ap1m1-ahsg
Description: Human serum albumin coimmunoprecipitation
Type: association
Interaction type: association
Accession: EBI-1813191
Name: association
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
Annotations:
Topic
Text
Supplementary Table 3

Participants (64)

pp1234pp
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
pp1234pp
1
EBI-714423
 logo
dastyLogo
GIG42
ALB
PRO0903

[+6]
Serum albumin
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
bait
Experimental role: bait
Accession: EBI-49
Name: bait
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally treated to capture its interacting partners.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Serum albumin

Participant: Serum albumin

Accession: EBI-1224072

Name: EBI-714423


A
Participant: Serum albumin

Participant: Serum albumin

Accession: EBI-1224072

Name: EBI-714423

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Serum albumin

Participant: Serum albumin

Accession: EBI-1224072

Name: EBI-714423

Stoichiometry: 0.0
S
Participant: Serum albumin

Participant: Serum albumin

Accession: EBI-1224072

Name: EBI-714423

Features:

F
Participant: Serum albumin

Participant: Serum albumin

Accession: EBI-1224072

Name: EBI-714423

Confidences:
Type
Value
No records found.
C
2
EBI-1223944
 logo
dastyLogo
PF4V1
SCYB4V1
CXCL4V1

[+4]
Platelet factor 4 variant
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Platelet factor 4 variant

Participant: Platelet factor 4 variant

Accession: EBI-1224023

Name: EBI-1223944


A
Participant: Platelet factor 4 variant

Participant: Platelet factor 4 variant

Accession: EBI-1224023

Name: EBI-1223944

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Platelet factor 4 variant

Participant: Platelet factor 4 variant

Accession: EBI-1224023

Name: EBI-1223944

Stoichiometry: 0.0
S
Participant: Platelet factor 4 variant

Participant: Platelet factor 4 variant

Accession: EBI-1224023

Name: EBI-1223944

Features:

F
Participant: Platelet factor 4 variant

Participant: Platelet factor 4 variant

Accession: EBI-1224023

Name: EBI-1223944

Confidences:
Type
Value
No records found.
C
3
EBI-1223708
 logo
dastyLogo
CFH
HF
HF1

[+2]
Complement factor H
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Complement factor H

Participant: Complement factor H

Accession: EBI-1224024

Name: EBI-1223708


A
Participant: Complement factor H

Participant: Complement factor H

Accession: EBI-1224024

Name: EBI-1223708

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Complement factor H

Participant: Complement factor H

Accession: EBI-1224024

Name: EBI-1223708

Stoichiometry: 0.0
S
Participant: Complement factor H

Participant: Complement factor H

Accession: EBI-1224024

Name: EBI-1223708

Features:

F
Participant: Complement factor H

Participant: Complement factor H

Accession: EBI-1224024

Name: EBI-1223708

Confidences:
Type
Value
No records found.
C
4
EBI-1221028
 logo
dastyLogo
QTRTD1
Queuine tRNA-ribosyltransferase domain-containing protein 1
Queuine tRNA-ribosyltransferase subunit QTRTD1
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Accession: EBI-1224025

Name: EBI-1221028


A
Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Accession: EBI-1224025

Name: EBI-1221028

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Accession: EBI-1224025

Name: EBI-1221028

Stoichiometry: 0.0
S
Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Accession: EBI-1224025

Name: EBI-1221028

Features:

F
Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Participant: Queuine tRNA-ribosyltransferase subunit QTRTD1

Accession: EBI-1224025

Name: EBI-1221028

Confidences:
Type
Value
No records found.
C
5
EBI-351506
 logo
dastyLogo
GSN
Actin-depolymerizing factor
Brevin

[+1]
Gelsolin
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Gelsolin

Participant: Gelsolin

Accession: EBI-1224026

Name: EBI-351506


A
Participant: Gelsolin

Participant: Gelsolin

Accession: EBI-1224026

Name: EBI-351506

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Gelsolin

Participant: Gelsolin

Accession: EBI-1224026

Name: EBI-351506

Stoichiometry: 0.0
S
Participant: Gelsolin

Participant: Gelsolin

Accession: EBI-1224026

Name: EBI-351506

Features:

F
Participant: Gelsolin

Participant: Gelsolin

Accession: EBI-1224026

Name: EBI-351506

Confidences:
Type
Value
No records found.
C
6
EBI-718973
 logo
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Small-inducible cytokine B7
Leukocyte-derived growth factor
Macrophage-derived growth factor

[+7]
Platelet basic protein
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Platelet basic protein

Participant: Platelet basic protein

Accession: EBI-1224027

Name: EBI-718973


A
Participant: Platelet basic protein

Participant: Platelet basic protein

Accession: EBI-1224027

Name: EBI-718973

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Platelet basic protein

Participant: Platelet basic protein

Accession: EBI-1224027

Name: EBI-718973

Stoichiometry: 0.0
S
Participant: Platelet basic protein

Participant: Platelet basic protein

Accession: EBI-1224027

Name: EBI-718973

Features:

F
Participant: Platelet basic protein

Participant: Platelet basic protein

Accession: EBI-1224027

Name: EBI-718973

Confidences:
Type
Value
No records found.
C
7
EBI-355972
 logo
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F7
Serum prothrombin conversion accelerator
Proconvertin
Coagulation factor VII
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Coagulation factor VII

Participant: Coagulation factor VII

Accession: EBI-1224028

Name: EBI-355972


A
Participant: Coagulation factor VII

Participant: Coagulation factor VII

Accession: EBI-1224028

Name: EBI-355972

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Coagulation factor VII

Participant: Coagulation factor VII

Accession: EBI-1224028

Name: EBI-355972

Stoichiometry: 0.0
S
Participant: Coagulation factor VII

Participant: Coagulation factor VII

Accession: EBI-1224028

Name: EBI-355972

Features:

F
Participant: Coagulation factor VII

Participant: Coagulation factor VII

Accession: EBI-1224028

Name: EBI-355972

Confidences:
Type
Value
No records found.
C
8
EBI-1223608
 logo
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CHKB
CHETK
CHKL

[+5]
Choline/ethanolamine kinase
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Choline/ethanolamine kinase

Participant: Choline/ethanolamine kinase

Accession: EBI-1224029

Name: EBI-1223608


A
Participant: Choline/ethanolamine kinase

Participant: Choline/ethanolamine kinase

Accession: EBI-1224029

Name: EBI-1223608

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Choline/ethanolamine kinase

Participant: Choline/ethanolamine kinase

Accession: EBI-1224029

Name: EBI-1223608

Stoichiometry: 0.0
S
Participant: Choline/ethanolamine kinase

Participant: Choline/ethanolamine kinase

Accession: EBI-1224029

Name: EBI-1223608

Features:

F
Participant: Choline/ethanolamine kinase

Participant: Choline/ethanolamine kinase

Accession: EBI-1224029

Name: EBI-1223608

Confidences:
Type
Value
No records found.
C
9
EBI-1223774
 logo
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DDM36
IGDCC4
KIAA1628

[+3]
Immunoglobulin superfamily DCC subclass member 4
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Immunoglobulin superfamily DCC subclass member 4

Participant: Immunoglobulin superfamily DCC subclass member 4

Accession: EBI-1224030

Name: EBI-1223774


A
Participant: Immunoglobulin superfamily DCC subclass member 4

Participant: Immunoglobulin superfamily DCC subclass member 4

Accession: EBI-1224030

Name: EBI-1223774

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Immunoglobulin superfamily DCC subclass member 4

Participant: Immunoglobulin superfamily DCC subclass member 4

Accession: EBI-1224030

Name: EBI-1223774

Stoichiometry: 0.0
S
Participant: Immunoglobulin superfamily DCC subclass member 4

Participant: Immunoglobulin superfamily DCC subclass member 4

Accession: EBI-1224030

Name: EBI-1223774

Features:

F
Participant: Immunoglobulin superfamily DCC subclass member 4

Participant: Immunoglobulin superfamily DCC subclass member 4

Accession: EBI-1224030

Name: EBI-1223774

Confidences:
Type
Value
No records found.
C
10
EBI-1220811
 logo
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TLN2
KIAA0320
Talin-2
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Talin-2

Participant: Talin-2

Accession: EBI-1224031

Name: EBI-1220811


A
Participant: Talin-2

Participant: Talin-2

Accession: EBI-1224031

Name: EBI-1220811

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Talin-2

Participant: Talin-2

Accession: EBI-1224031

Name: EBI-1220811

Stoichiometry: 0.0
S
Participant: Talin-2

Participant: Talin-2

Accession: EBI-1224031

Name: EBI-1220811

Features:

F
Participant: Talin-2

Participant: Talin-2

Accession: EBI-1224031

Name: EBI-1220811

Confidences:
Type
Value
No records found.
C
11
EBI-1220319
 logo
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FN1
FN
Cold-insoluble globulin
Fibronectin
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Fibronectin

Participant: Fibronectin

Accession: EBI-1224032

Name: EBI-1220319


A
Participant: Fibronectin

Participant: Fibronectin

Accession: EBI-1224032

Name: EBI-1220319

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Fibronectin

Participant: Fibronectin

Accession: EBI-1224032

Name: EBI-1220319

Stoichiometry: 0.0
S
Participant: Fibronectin

Participant: Fibronectin

Accession: EBI-1224032

Name: EBI-1220319

Features:

F
Participant: Fibronectin

Participant: Fibronectin

Accession: EBI-1224032

Name: EBI-1220319

Confidences:
Type
Value
No records found.
C
12
EBI-1223619
 logo
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C4A
CO4
CPAMD2

[+2]
Complement C4-A
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Complement C4-A

Participant: Complement C4-A

Accession: EBI-1224033

Name: EBI-1223619


A
Participant: Complement C4-A

Participant: Complement C4-A

Accession: EBI-1224033

Name: EBI-1223619

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Complement C4-A

Participant: Complement C4-A

Accession: EBI-1224033

Name: EBI-1223619

Stoichiometry: 0.0
S
Participant: Complement C4-A

Participant: Complement C4-A

Accession: EBI-1224033

Name: EBI-1223619

Features:

F
Participant: Complement C4-A

Participant: Complement C4-A

Accession: EBI-1224033

Name: EBI-1223619

Confidences:
Type
Value
No records found.
C
13
EBI-357285
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ST13
HIP
SNC6

[+8]
Hsc70-interacting protein
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Hsc70-interacting protein

Participant: Hsc70-interacting protein

Accession: EBI-1224034

Name: EBI-357285


A
Participant: Hsc70-interacting protein

Participant: Hsc70-interacting protein

Accession: EBI-1224034

Name: EBI-357285

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Hsc70-interacting protein

Participant: Hsc70-interacting protein

Accession: EBI-1224034

Name: EBI-357285

Stoichiometry: 0.0
S
Participant: Hsc70-interacting protein

Participant: Hsc70-interacting protein

Accession: EBI-1224034

Name: EBI-357285

Features:

F
Participant: Hsc70-interacting protein

Participant: Hsc70-interacting protein

Accession: EBI-1224034

Name: EBI-357285

Confidences:
Type
Value
No records found.
C
14
EBI-1050007
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TIAM1
T-lymphoma invasion and metastasis-inducing protein 1
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: T-lymphoma invasion and metastasis-inducing protein 1

Participant: T-lymphoma invasion and metastasis-inducing protein 1

Accession: EBI-1224035

Name: EBI-1050007


A
Participant: T-lymphoma invasion and metastasis-inducing protein 1

Participant: T-lymphoma invasion and metastasis-inducing protein 1

Accession: EBI-1224035

Name: EBI-1050007

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: T-lymphoma invasion and metastasis-inducing protein 1

Participant: T-lymphoma invasion and metastasis-inducing protein 1

Accession: EBI-1224035

Name: EBI-1050007

Stoichiometry: 0.0
S
Participant: T-lymphoma invasion and metastasis-inducing protein 1

Participant: T-lymphoma invasion and metastasis-inducing protein 1

Accession: EBI-1224035

Name: EBI-1050007

Features:

F
Participant: T-lymphoma invasion and metastasis-inducing protein 1

Participant: T-lymphoma invasion and metastasis-inducing protein 1

Accession: EBI-1224035

Name: EBI-1050007

Confidences:
Type
Value
No records found.
C
15
EBI-1050253
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Meningioma-expressed antigen 6/11
CTAGE5
MGEA11

[+3]
cTAGE family member 5
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: cTAGE family member 5

Participant: cTAGE family member 5

Accession: EBI-1224036

Name: EBI-1050253


A
Participant: cTAGE family member 5

Participant: cTAGE family member 5

Accession: EBI-1224036

Name: EBI-1050253

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: cTAGE family member 5

Participant: cTAGE family member 5

Accession: EBI-1224036

Name: EBI-1050253

Stoichiometry: 0.0
S
Participant: cTAGE family member 5

Participant: cTAGE family member 5

Accession: EBI-1224036

Name: EBI-1050253

Features:

F
Participant: cTAGE family member 5

Participant: cTAGE family member 5

Accession: EBI-1224036

Name: EBI-1050253

Confidences:
Type
Value
No records found.
C
16
EBI-1223932
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OR3A2
OLFRA04
Olfactory receptor 17-228

[+1]
Olfactory receptor 3A2
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:
Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details
Accession:

Name:



-
prey
Experimental role: prey
Accession: EBI-58
Name: prey
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Molecule experimentally identified as being captured by a given bait.
unspecified role
Biological role: unspecified role
Accession: EBI-77781
Name: unspecified role
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
Annotations:
Topic
Text
Role not specified or not applicable to the data.
protein
Interactor type: protein
Accession: EBI-619654
Name: protein
Cross References:
Database
Identifier
Secondary identifier
Qualifier
-
-
-
Annotations:
Topic
Text
A linear polymer of amino acids joined by peptide bonds in a specific sequence.
Participant: Olfactory receptor 3A2

Participant: Olfactory receptor 3A2

Accession: EBI-1224037

Name: EBI-1223932


A
Participant: Olfactory receptor 3A2

Participant: Olfactory receptor 3A2

Accession: EBI-1224037

Name: EBI-1223932

Parameters:
Type
Value
Unit
Base
Exponent
Uncertainty
No records found.
P

Participant: Olfactory receptor 3A2

Participant: Olfactory receptor 3A2

Accession: EBI-1224037

Name: EBI-1223932

Stoichiometry: 0.0
S
Participant: Olfactory receptor 3A2

Participant: Olfactory receptor 3A2

Accession: EBI-1224037

Name: EBI-1223932

Features:

F
Participant: Olfactory receptor 3A2

Participant: Olfactory receptor 3A2

Accession: EBI-1224037

Name: EBI-1223932

Confidences:
Type
Value
No records found.
C
17
EBI-714423
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GIG42
ALB
PRO0903

[+6]
Serum albumin
Homo sapiens
Organism Details
Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References: