cyclin E1-CDK2 complex

Species: Homo sapiens; 9606
Accession number: EBI-768477

Summary


Systematic Name:

CCNE1:CDK2

Function:

Cyclin-dependent protein kinase complex. Required for G1 to S phase transition of the mitotic cell cycle. Hyper-phosphorylation of Rb proteins by cyclin E:CDK2 complexes leads to their inactivation which allows transcription of E2F-controlled genes such as cyclin E1 itself. Additional substrates include the p27 cell cycle inhibitor and the NPAT/p220 transcription factor Complex formation enables substrate binding to the kinase.

Complex Assembly:

Heterodimer


Participants

ID Name Description Stochiometry Biological Role Interactor Type Linked Features Other Features
P24941
EBI-375096
CDK2 Cyclin-dependent kinase 2 1 enzyme protein
binding-associated region P24864 [?-?]
P24864
EBI-519526
CCNE1 G1/S-specific cyclin-E1 1 unspecified role protein
binding-associated region P24941 [?-?]

Cross References

Type Database Identifier Description
identical object in an external resource chembl CHEMBL2094126
evidence ontology ECO:0000353
biological process gene ontology GO:0000082 G1/S transition of mitotic cell cycle
cellular component gene ontology GO:0097134 cyclin E1-CDK2 complex
Experimental evidence that interaction occurs intact EBI-519628
identical object in an external resource intenz 2.7.11.22
identical object in an external resource protein ontology PR:000026768
additional information pubmed 15838514
identical object in an external resource reactome REACT_2714.1
identical object in an external resource reactome REACT_4199.1
identical object in an external resource reactome REACT_4601.1
identical object in an external resource wwpdb 1w98