Cyclin A2-CDK2 complex

Species: Homo sapiens; 9606
Accession number: EBI-767671

Summary


Systematic Name:

CCNA2:CDK2

Synonyms:
CCNA2:CDK2
Small molecule
Protein
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Gene
DNA
RNA


Function:

Cyclin-dependent protein kinase complex. Required in G1 phase of cell cycle. Complex formation enables substrate binding to the kinase, leads to a rearrangement of the catalytic site and exposes Thr-160 of CDK2 for phosphorylation and subsequent activation.

Complex Assembly:

Heterodimer


Participants

ID Name Description Stoichiometry Biological Role Interactor Type Other Features
P24941
CDK2 Cyclin-dependent kinase 2 1 enzyme protein
P20248
CCNA2 Cyclin-A2 1 unspecified role protein

Cross References

Type Database Identifier Description
identical object in an external resource ChEMBL target CHEMBL2094128
evidence ontology ECO:0000353
cellular component gene ontology GO:0097124 cyclin A2-CDK2 complex
Experimental evidence that interaction occurs intact EBI-1039274
identical object in an external resource intenz 2.7.11.22
identical object in an external resource wwpdb 1VYW
identical object in an external resource wwpdb 1e9h
identical object in an external resource wwpdb 1fin
identical object in an external resource wwpdb 1fvv
identical object in an external resource wwpdb 1h1p
identical object in an external resource wwpdb 1h1q
identical object in an external resource wwpdb 1h1r
identical object in an external resource wwpdb 1h1s
identical object in an external resource wwpdb 1jst
identical object in an external resource wwpdb 1ogu
identical object in an external resource wwpdb 1oi9
identical object in an external resource wwpdb 1oiu
identical object in an external resource wwpdb 1oiy
identical object in an external resource wwpdb 1p5e
identical object in an external resource wwpdb 1pkd
identical object in an external resource wwpdb 2bkz
identical object in an external resource wwpdb 2bpm
identical object in an external resource wwpdb 2c4g
identical object in an external resource wwpdb 2c5n
identical object in an external resource wwpdb 2c5o
identical object in an external resource wwpdb 2c5x
identical object in an external resource wwpdb 2c6t
identical object in an external resource wwpdb 2cjm
identical object in an external resource wwpdb 2i40
identical object in an external resource wwpdb 2iw6
identical object in an external resource wwpdb 2iw8
identical object in an external resource wwpdb 2iw9
identical object in an external resource wwpdb 2uzb
identical object in an external resource wwpdb 2uzd
identical object in an external resource wwpdb 2uze
identical object in an external resource wwpdb 2uzl
identical object in an external resource wwpdb 2wih
identical object in an external resource wwpdb 2wip
identical object in an external resource wwpdb 2wpa
identical object in an external resource wwpdb 2wxv
identical object in an external resource wwpdb 3eid
identical object in an external resource wwpdb 3ej1
identical object in an external resource wwpdb 3eoc
identical object in an external resource wwpdb 3f5x
identical object in an external resource wwpdb 4bck
identical object in an external resource wwpdb 4bcm
identical object in an external resource wwpdb 4bcn
identical object in an external resource wwpdb 4bcp
identical object in an external resource wwpdb 4cfm
identical object in an external resource wwpdb 4cfn
identical object in an external resource wwpdb 4cfu
identical object in an external resource wwpdb 4cfv
identical object in an external resource wwpdb 4cfw
identical object in an external resource wwpdb 4cfx
identical object in an external resource wwpdb 4eoi
identical object in an external resource wwpdb 4eoj
identical object in an external resource wwpdb 4eok
identical object in an external resource wwpdb 4eol
identical object in an external resource wwpdb 4eom
identical object in an external resource wwpdb 4eon
identical object in an external resource wwpdb 4eoo
identical object in an external resource wwpdb 4eop
identical object in an external resource wwpdb 4eoq
identical object in an external resource wwpdb 4eor
identical object in an external resource wwpdb 4eos
identical object in an external resource wwpdb 4fx3
Curated by: IntAct