cyclin A2-CDK2 complex

Species: Homo sapiens; 9606
Accession number: EBI-767671

Summary


Synonyms:
CCNA2:CDK2
Function:

Cyclin-dependent protein kinase complex. Required in G1 phase of cell cycle. Complex formation enables substrate binding to the kinase, leads to a rearrangement of the catalytic site and exposes Thr-160 of CDK2 for phosphorylation and subsequent activation.

Complex Assembly:

Heterodimer


Participants

ID Name Description Stochiometry Biological Role Interactor Type Linked Features Other Features
P20248
EBI-457097
CCNA2 Cyclin-A2 1 unspecified role protein
binding-associated region P24941 [?-?]
P24941
EBI-375096
CDK2 Cyclin-dependent kinase 2 1 enzyme protein
binding-associated region P20248 [?-?]

Cross References

Type Database Identifier Description
identical object in an external resource ChEMBL target CHEMBL2094128
evidence ontology ECO:0000353
biological process gene ontology GO:0051318 G1 phase
cellular component gene ontology GO:0097124 cyclin A2-CDK2 complex
Experimental evidence that interaction occurs intact EBI-1039274
identical object in an external resource intenz 2.7.11.22
identical object in an external resource wwpdb 1VYW