6-phosphofructokinase, M2L2 heterotetramer

Species: Homo sapiens; 9606
Accession number: EBI-764901

Summary


Systematic Name:

2xPFKL:2xPFKM

Synonyms:
PFK-M2L2 6-phosphofructokinase
phosphofructokinase phosphohexokinase
6PF-1-K Pfk-1
PFK
Bioactive entity
Protein
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Gene
DNA
RNA


Function:

Heterotetramer

Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate in the presence of MgATP, the first irreversible step for glycolysis. Present in the erythrocyte.


Participants

ID Name Description Stoichiometry Biological Role Interactor Type Other Features
P17858
PFKL ATP-dependent 6-phosphofructokinase, liver type 2 enzyme protein
P08237
PFKM ATP-dependent 6-phosphofructokinase, muscle type 2 enzyme protein

Cross References

Type Database Identifier Description
Experimental evidence that interaction occurs intact EBI-514812
additional information pubmed 11949936
cellular component gene ontology GO:0005945 6-phosphofructokinase complex
molecular function gene ontology GO:0003872 6-phosphofructokinase activity
biological process gene ontology GO:0006096 glycolytic process
evidence ontology ECO:0000353
identical object in an external resource protein ontology PR:000027415
identical object in an external resource reactome R-HSA-70463
identical object in an external resource intenz 2.7.1.11
Curated by: IntAct