6-phosphofructokinase, L4 homotetramer

Species: Homo sapiens; 9606
Accession number: EBI-764772


Systematic Name:

PFKL tetramer

Phosphofructokinase, liver-type homotetramer PFK-L4 6-phosphofructokinase
phosphofructokinase phosphohexokinase 6PF-1-K
Pfk-1 PFK

Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate in the presence of MgATP, the first irreversible step for glycolysis. Predominant form in the liver.


Km vs fructose bisphosphate=2.3mM when [ATP]=2.0mM. Inhibited by ATP and citrate; activated by glucose 1,6 diphosphate.

Complex Assembly:



ID Name Description Stochiometry Biological Role Interactor Type Linked Features Other Features
PFKL ATP-dependent 6-phosphofructokinase, liver type 4 unspecified role protein

Cross References

Type Database Identifier Description
evidence ontology ECO:0000353
biological process gene ontology GO:0006096 glycolytic process
cellular component gene ontology GO:0005945 6-phosphofructokinase complex
molecular function gene ontology GO:0003872 6-phosphofructokinase activity
Experimental evidence that interaction occurs intact EBI-514784
identical object in an external resource intenz
identical object in an external resource protein ontology PR:000027421
additional information pubmed 11949936
identical object in an external resource reactome REACT_2915.1