Ripoptosome

Species: Homo sapiens; 9606
Accession number: EBI-6137287

Summary


Systematic Name:

CASP8:FADD:RIPK1

Bioactive entity
Protein
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Gene
DNA
RNA


Function:

Intracellular complex whose formation can induce either the extrinsic apoptotic signaling pathway or necroptosis. Central components are RIPK1 and CASP8, linked through FADD. Formation induced upon stimulation of membrane-bound receptors (TRAIL, CD95 or TLR3) and dependent on depletion of IAP (inhibitor-of-apoptosis) proteins caused by cytokine stimulation, cellular stress or treatment with IAP antagonists. Can recruit different isoforms of IAPs, such as cFLIPs or cFLIPl. Can induce necroptosis or apoptosis, depending on the composition of heterodimers of CASP8 and cFLIP isoforms: predominance of CASP8-CASP8 homidimers induces apoptosis, predominance of CASP8-cFLIP heterodimers induces necroptosis. RIPK3 seems to be dowstream target when the complex induces necroptosis.


Participants

ID Name Description Stoichiometry Biological Role Interactor Type Other Features
Q13546
RIPK1 Receptor-interacting serine/threonine-protein kinase 1 unspecified role protein
Q13158
FADD FAS-associated death domain protein unspecified role protein
Q14790
CASP8 Caspase-8 unspecified role protein

Cross References

Type Database Identifier Description
Experimental evidence that interaction occurs intact EBI-4322110
Experimental evidence that interaction occurs intact EBI-6137146
primary-reference pubmed 22274400
cellular component gene ontology GO:0097342 ripoptosome
biological process gene ontology GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
biological process gene ontology GO:0060545 positive regulation of necroptotic process
evidence ontology ECO:0000353
Curated by: IntAct