mitochondrial respiratory chain complex IV variant 1

Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292
Accession number: EBI-2436444

Summary


Systematic Name:

COX1:COX2:COX3:COX5A:COX6:COX7:COX8:COX9:COX12:COX13

Synonyms:
Cytochrome C oxidase variant 1 Cytochrome c oxidase NADH cytochrome c oxidase
mitochondrial electron transport complex IV variant 1 cytochrome a3 ferrocytochrome c: oxygen oxidoreductase.
Function:

Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. A complex metalloprotein that transfers electrons from reduced cytochrome c to molecular oxygen and conserves the free energy released in this exergonic reaction by maintaining a transmembrane proton gradient which is utilized to drive the synthesis of ATP or ion transport across the membrane. The four protons consumed in the reduction of one oxygen molecule to water are taken from the mitochondrial matrix and, coupled to this reaction, four additional protons are translocated from the matrix to the intermembrane space.


Participants

ID Name Description Stochiometry Biological Role Interactor Type Linked Features Other Features
P04037-PRO_0000006114
EBI-2435971
COX4 Cytochrome c oxidase subunit 4, mitochondrial 1 unspecified role protein
P10174
EBI-2050505
COX7 Cytochrome c oxidase subunit 7 1 unspecified role protein
P32799-PRO_0000006127
EBI-2435983
COX13 Cytochrome c oxidase subunit 6A, mitochondrial 1 unspecified role protein
P00410-PRO_0000006048
EBI-2435967
COX2 Cytochrome c oxidase subunit 2 1 unspecified role protein
P00420
EBI-2435943
COX3 Cytochrome c oxidase subunit 3 1 unspecified role protein
P00427-PRO_0000006108
EBI-2435978
COX6 Cytochrome c oxidase subunit 6, mitochondrial 1 unspecified role protein
Q01519
EBI-5078
COX12 Cytochrome c oxidase subunit 6B 1 unspecified role protein
P04039-PRO_0000006173
EBI-2435994
COX8 Cytochrome c oxidase polypeptide VIII, mitochondrial 2 unspecified role protein
P00401
EBI-2435921
COX1 Cytochrome c oxidase subunit 1 1 unspecified role protein
P07255-PRO_0000006076
EBI-2435987
COX9 Cytochrome c oxidase subunit 7A 1 unspecified role protein
P00424-PRO_0000006097
EBI-2435975
COX5A Cytochrome c oxidase polypeptide 5A, mitochondrial 1 unspecified role protein

Cross References

Type Database Identifier Description
evidence ontology ECO:0000353
biological process gene ontology GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
cellular component gene ontology GO:0005751 mitochondrial respiratory chain complex IV
molecular function gene ontology GO:0004129 cytochrome-c oxidase activity
molecular function gene ontology GO:0005507 copper ion binding
molecular function gene ontology GO:0020037 heme binding
molecular function gene ontology GO:0045154 electron transporter, transferring electrons within cytochrome c oxidase complex activity
Experimental evidence that interaction occurs intact EBI-2435962
identical object in an external resource intenz 1.9.3.1
additional information pubmed 18975062