Mitochondrial respiratory chain complex IV variant 1

Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292
Accession number: EBI-2436444

Summary


Systematic Name:

COX1:COX2:COX3:COX5A:COX6:COX7:COX8:COX9:COX12:COX13

Synonyms:
Cytochrome C oxidase variant 1 Cytochrome c oxidase
NADH cytochrome c oxidase mitochondrial electron transport complex IV variant 1
cytochrome a3 ferrocytochrome c: oxygen oxidoreductase.
Bioactive entity
Protein
- click or tap to toggle between circle and bar (bar shows binding sites, if known)
Gene
DNA
RNA


Function:

Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. A complex metalloprotein that transfers electrons from reduced cytochrome c to molecular oxygen and conserves the free energy released in this exergonic reaction by maintaining a transmembrane proton gradient which is utilized to drive the synthesis of ATP or ion transport across the membrane. The four protons consumed in the reduction of one oxygen molecule to water are taken from the mitochondrial matrix and, coupled to this reaction, four additional protons are translocated from the matrix to the intermembrane space.


Participants

ID Name Description Stoichiometry Biological Role Interactor Type Other Features
P10174
COX7 Cytochrome c oxidase subunit 7 1 unspecified role protein
P00401
COX1 Cytochrome c oxidase subunit 1 1 unspecified role protein
P00420
COX3 Cytochrome c oxidase subunit 3 1 unspecified role protein
P00410-PRO_0000006048
COX2 Cytochrome c oxidase subunit 2 1 unspecified role protein
P04037-PRO_0000006114
COX4 Cytochrome c oxidase subunit 4, mitochondrial 1 unspecified role protein
P00424-PRO_0000006097
COX5A Cytochrome c oxidase polypeptide 5A, mitochondrial 1 unspecified role protein
P00427-PRO_0000006108
COX6 Cytochrome c oxidase subunit 6, mitochondrial 1 unspecified role protein
P32799-PRO_0000006127
COX13 Cytochrome c oxidase subunit 6A, mitochondrial 1 unspecified role protein
P07255-PRO_0000006076
COX9 Cytochrome c oxidase subunit 7A 1 unspecified role protein
P04039-PRO_0000006173
COX8 Cytochrome c oxidase polypeptide VIII, mitochondrial 2 unspecified role protein
Q01519
COX12 Cytochrome c oxidase subunit 6B 1 unspecified role protein

Cross References

Type Database Identifier Description
additional information pubmed 18975062
Experimental evidence that interaction occurs intact EBI-2435962
biological process gene ontology GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
cellular component gene ontology GO:0005751 mitochondrial respiratory chain complex IV
molecular function gene ontology GO:0004129 cytochrome-c oxidase activity
molecular function gene ontology GO:0005507 copper ion binding
molecular function gene ontology GO:0020037 heme binding
molecular function gene ontology GO:0045154 electron transporter, transferring electrons within cytochrome c oxidase complex activity
evidence ontology ECO:0000353
identical object in an external resource intenz 1.9.3.1
Curated by: IntAct