ESCRT-III complex

Species: yeast; 559292
Accession number: EBI-2307968

Summary


Systematic Name:

DID4:SNF7:VPS20:VPS24

Synonyms:
ESCRT III complex ESCRT3 complex
Endosomal sorting complex required for transport-III complex ESCRT-3 complex
Bioactive entity
Protein
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Gene
DNA
RNA


Function:

A membrane fission complex that is part of the ESCRT machinery of ESCRT-0 (EBI-2307938), -I (EBI-1268517), -II (EBI-2307951), -III (this complex) and -IV (VPS4 complex, EBI-11560071). It is involved in multiple membrane fission processes: a) the final step of cell organelle fusion processes such as the biogenesis of intraluminal vesicles (ILV) in multivesicular bodies (MVB, a type of late endosomes), fusion of autophagosomes with MVB or lysosomes and amphisomes or MVB with lysosomes, thereby playing a crucial role in processes like autophagy and downregulation of cell-surface receptors, b) polarity, c) migration, d) miRNA activity, e) mRNA transport, f) repair of plasma membrane wounds, g) the final scission of cytokineses, h) nuclear envelope sealing by annular fusion, i) nuclear pore complex (NPC) surveillance and j) extraction of defective NPCs. ESCRT-III assembles into a highly ordered filament-like hetero-oligomer, which may spatially restrict membrane-curvature-inducing factors to initiate budding away from the cytoplasm. VPS20 nucleates the homo-oligomerization of SNF7 that is capped by VPS24. VPS24 recruits VPS2, initiates VPS4-dependent ESCRT-III dissasembly and binds phosphatidylinositol 3,5-diphosphate.


Participants

ID Name Description Stoichiometry Biological Role Interactor Type Other Features
P39929
SNF7 Vacuolar-sorting protein SNF7 unspecified role protein
P36108
DID4 DOA4-independent degradation protein 4 unspecified role protein
P36095
VPS24 Vacuolar protein-sorting-associated protein 24 unspecified role protein
Q04272
VPS20 Vacuolar protein sorting-associated protein 20 unspecified role protein

Cross References

Type Database Identifier Description
Experimental evidence that interaction occurs intact EBI-491630
Experimental evidence that interaction occurs intact EBI-2213958
cellular component gene ontology GO:0000815 ESCRT III complex
biological process gene ontology GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
additional information pubmed 17450176
Experimental evidence that interaction occurs intact EBI-6399231
evidence ontology ECO:0000353
Curated by: IntAct