ISW2 chromatin-remodeling complex variant 2

Species: Saccharomyces cerevisiae; 559292
Accession number: EBI-1252108


Systematic Name:


ISW2 chromatin-remodeling complex ISW2 complex
Imitation switch complex 2 CHRAC-like complex
Isw2p-Itc1p complex Imitation switch two complex.
CHRAC complex
Bioactive entity
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ATP-dependent chromatin remodeling complex which is required for repression of early meiotic genes during mitotic cell growth. Slides mononucleosomes from the end to the center of DNA and requires the flexible, acidic patch of the histone H4 tail to efficiently dock its translocase on the nucleosome, for stimulating the ATPase activity and inducing nucleosome mobility. Preferentially bind nucleosome substrates containing ~70 bp extranucleosomal DNA at one entry/exit site of the nucleosome. ISW2 interacts with three nucleosomal and extranucleosomal regions. Itc1 and Isw2 bind to the region 2 helical turns from the dyad axis and a region closest to the entry/exit site. Itc1 subunit makes extensive contacts with extranucleosomal DNA. The absence of the histone fold dimer Dpb4/Dls1 present in variant 1 (EBI-1252044) appears to alter the target gene profile regulated by this complex, the dimer acts to affect its nucleosome spacing activity, the ability to sense an adjacent nucleosome and to regulate remodeling.


ID Name Description Stoichiometry Biological Role Interactor Type Other Features
ITC1 Imitation switch two complex protein 1 unspecified role protein
ISW2 ISWI chromatin-remodeling complex ATPase ISW2 enzyme protein

Cross References

Type Database Identifier Description
evidence ontology ECO:0000353
cellular component gene ontology GO:0008623 CHRAC
biological process gene ontology GO:0043044 ATP-dependent chromatin remodeling
biological process gene ontology GO:0006355 regulation of transcription, DNA-templated
additional information pubmed 17491017
molecular function gene ontology GO:0005524 ATP binding
molecular function gene ontology GO:0003677 DNA binding
Experimental evidence that interaction occurs intact EBI-787286
molecular function gene ontology GO:0016887 ATPase activity
identical object in an external resource intenz 3.6.1
Curated by: IntAct