SLIK (SAGA-like) complex

Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292
Accession number: EBI-1251264

Summary


Systematic Name:

ADA2:CHD1:GCN5:HFI1:NGG1:RTG2:SGF73:SPT3:SPT7:SPT20:TAF5:TAF6:TAF9:TAF10:TAF12:TRA1:UBP8

Synonyms:
SALSA complex SAGA variant complex
SAGA altered Spt8 absent complex
SLIK SLIK/SALSA complex
Bioactive entity
Protein
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Gene
DNA
RNA


Function:

Required for growth under stressful conditions to activate transcription of stress-responsive, Pol II-transcribed genes. Acetylates nucleosomal H3 and H2B. Plays a role in the yeast retrograde response pathway that is important for gene expression changes during mitochondrial dysfunction.

Properties:

M.W. = 1.8 MDa. SALSA contains a C-terminally truncated SPT7.


Participants

ID Name Description Stoichiometry Biological Role Interactor Type Other Features
P32608
RTG2 Retrograde regulation protein 2 unspecified role protein
P50875
SPT20 Transcription factor SPT20 unspecified role protein
P06844
SPT3 Protein SPT3 unspecified role protein
P35177
SPT7 Transcriptional activator SPT7 unspecified role protein
P38129
TAF5 Transcription initiation factor TFIID subunit 5 unspecified role protein
P53040
TAF6 Transcription initiation factor TFIID subunit 6 unspecified role protein
Q12030
TAF10 Transcription initiation factor TFIID subunit 10 unspecified role protein
P50102
UBP8 Ubiquitin carboxyl-terminal hydrolase 8 unspecified role protein
Q02336
ADA2 Transcriptional adapter 2 unspecified role protein
P32494
NGG1 Chromatin-remodeling complexes subunit NGG1 unspecified role protein
P53165
SGF73 SAGA-associated factor 73 unspecified role protein
P38811
TRA1 Transcription-associated protein 1 unspecified role protein
Q05027
TAF9 Transcription initiation factor TFIID subunit 9 unspecified role protein
Q03761
TAF12 Transcription initiation factor TFIID subunit 12 unspecified role protein
P32657
CHD1 Chromo domain-containing protein 1 unspecified role protein
Q03330
GCN5 Histone acetyltransferase GCN5 unspecified role protein
Q12060
HFI1 Transcriptional coactivator HFI1/ADA1 unspecified role protein

Cross References

Type Database Identifier Description
biological process gene ontology GO:0006357 regulation of transcription from RNA polymerase II promoter
biological process gene ontology GO:0016573 histone acetylation
additional information pubmed 12186975
Experimental evidence that interaction occurs intact EBI-763345
Experimental evidence that interaction occurs intact EBI-1189559
cellular component gene ontology GO:0046695 SLIK (SAGA-like) complex
additional information pubmed 17337012
evidence ontology ECO:0000353
identical object in an external resource intenz 2.3.1.48
identical object in an external resource intenz 3.1.2.15
Curated by: IntAct