Mitochondrial outer membrane translocase holocomplex

Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292
Accession number: EBI-1180520


Systematic Name:


Tom holocomplex Mitochondrial outer membrane translocase holocomplex
Preprotein translocase of the outer mitochondrial membrane
Small molecule
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Translocase in the outer mitochondrial membrane that mediates the import of precursor protein and mediates inset of some resident outer membrane proteins. The holo TOM complex contains two or three pores, each of which has a diameter of approximately 20A. When translocation by the TOM complex is coupled with that by the TIM23 or TIM22 complex, the TOM channel can operate as a passive pore to allow passage of the polypeptide segment, which is `pulled' by the TIM complex with the aid of differenial membrane potential and/or ATP. When translocation is uncoupled from the inner-membrane translocators, the TOM complex uses both the stop-transfer pathway, which consists of two steps, the first requiring a membrane potential and an ATP-dependent chaperone mHsp70, and a second mechanism involving the folding of an N-terminal domain that has already crossed the outer membrane and can function as a trap in the intermembrane space to drive translocation of the C-terminal part of the protein by a Brownian ratchet mechanism.


ID Name Description Stoichiometry Biological Role Interactor Type Other Features
TOM5 Mitochondrial import receptor subunit TOM5 unspecified role protein
TOM6 Mitochondrial import receptor subunit TOM6 unspecified role protein
TOM7 Mitochondrial import receptor subunit TOM7 unspecified role protein
TOM20 Mitochondrial import receptor subunit TOM20 unspecified role protein
TOM22 Mitochondrial import receptor subunit TOM22 unspecified role protein
TOM40 Mitochondrial import receptor subunit TOM40 unspecified role protein
TOM70 Mitochondrial import receptor subunit TOM70 unspecified role protein

Cross References

Type Database Identifier Description
evidence ontology ECO:0000353
biological process gene ontology GO:0045040 protein import into mitochondrial outer membrane
cellular component gene ontology GO:0005742 mitochondrial outer membrane translocase complex
molecular function gene ontology GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Experimental evidence that interaction occurs intact EBI-1180448
additional information pubmed 12857785
Curated by: IntAct