spacer

The Virtual Physiological Human Workshop

2-3 February 2009

Dear Associates,

The EBI will host The Virtual Physiological Human Project Workshop on the 2nd to 3rd February 2009.

The venue will be the Francis Crick Auditorium at the Wellcome Trust Conference Centre on the 2nd February and the EBI IT Training room on the 3rd February.

This meeting will present efforts by the Virtual Physiological Human (VPH) community, as well as other specialities, to model human structures and their function across different scales. This event also aims to advance the computational unification of anatomy in biological and pharmacological databases, physiological models, radiological images and clinical records.

Updates on key research in academia and industry will discuss the modelling of concepts (e.g. disease ontologies), structures (e.g. protein structure, volumetric data) and processes (e.g. viral mechanisms, blood pressure regulation). Ways to foster the interoperability of such modelling methods will also be explored, together with approaches to improve access to clinical phenotypic data for basic research.

This event sets the stage to establish a community toolkit to achieve model interoperability across the VPH community. In particular, design solutions will be sought for the rigorous representation of human anatomy and the close study of its dynamic change in physiology, its orchestrated alteration in development, and its distortion in disease.

Organisers and contacts:

This meeting is organized by the Virtual Physiological Human Network of Excellence, in collaboration with the coordinator of the EBI Industry Programme, Dr. Dominic Clark (EMBL-EBI).

The scientific programme for this meeting was co-ordinated by Prof. Peter Hunter (University of Auckland), Prof. Alex Frangi (University Pompeu Fabra), and Dr Bernard de Bono (EMBL-EBI).

We would like to invite you to attend this workshop - please find here below a preliminary agenda. The 2nd February will be an open day to all and the 3rd February a closed workshop.

 

Agenda:

Time Agenda
Monday 2 February 2009 - The Virtual Physiological Human - the Anatomical Basis of Disease
08.30 Registration Tea/Coffee
09.00 Welcome and Introductions, Dominic Clark (EMBL-EBI), Peter Hunter (Univ. of Auckland), Bernard de Bono (EMBL-EBI)
  Session 1: Concepts of Anatomy and Disease - Chair: Lynn Schriml (Univ. of Maryland)
09.30 The Foundational Model of Anatomy, Onard Mejino (Univ. of Washington Scholl of Medicine)
10.00 SNOMED CT as a Tool to Support Interoperation of Clinical and Research Data, Kent Spackman (IHTSDO)
10.30 Integrating Data and Models Using the Disease Ontology, Warren Kibbe (NorthWestern Univ.) and Lynn Schriml (U. Maryland School of Medicine)
11.00 Tea/Coffee
  Session 2: Organising Anatomical Models - Chair Bernard de Bono (EMBL-EBI)
11.30 Statistical Model of Radiological Anatomy, Alex Frangi (Univ. Pompeu Fabra)
12.00 Volumetric Annotation of Mouse Anatomy, Duncan Davidson (MRC, Edinburgh)
12.30 The VPH/Physiome Modelling Languages , Peter Hunter (Univ. of Auckland)
13.00 Lunch
  Session 3: Modelling Anatomical Physiology - Chair Dan Cook (univ. of Washington School of Medicine)
14.00 Multi-scale Modelling in Musculoskeletal Mechanics, Marco Viceconti (Rizzoli Inst.)
14.30

Multi-scale Modelling of Kidney Function in the Context of Blood Pressure Regulation and Fluid Homeostasis, Randy Thomas (CNRS)

15.00 Virtual Organisms in the Prediction of Pharmacokinetics - Principles and Applications, Simon Thomas (Cyprotex Ltd)
15.30 Tea/Coffee
  Session 4: Bridging Across Anatomical Scales - Chair Jesper Tenger (Karolinska Inst.)
16.00 Using anatomy Ontologies to Interoperate Across Mouse Database Resources , Jonathan Bard (Weatherall Institute, Oxford)
16.30 Towards Global Pharmacodynamics - Predicting the Compartmental Location of Proteins, Thomas Skot-Jensen (Denmark Technical Univ.)
17.00 Building the Virtual Physiological Human , Bernard de Bono (EMBL-EBI)
17.30 The Ontology of Physics for Biology, Dan Cook & Onard Mejino (Univ. of Washington)
18.30 Drinks Reception, Hinxton Hall Foyer and Lounges
19.00 Dinner, Conference Centre Restaurant
Tuesday 3 February 2009 - The Virtual Physiological Human - Modelling for the Pharma & Biotech Industry
08.45 Welcome and Introduction, Dominic Clark (EMBL-EBI), Bernard de Bono (EMBL-EBI)
  Session 1: Modelling at Molecular Scale - Chair: Peter Hunter (Univ. of Auckland)
09.00 Molecular Modelling and Computing Infrastructures, Peter Coveney (UCL)
09.30 VPH Strategies in Predicting Cardiotoxicity, Blanca Rodriguez (Univ. of Oxford)
10.30 Computational Fluid Dynamics Simulation for the Clinic, Rod Hose (Sheffield)
11.00 Tea/Coffee
  Session 2: Large Scale Interoperability - Chair: Catherine Gale (UCL)
11.30 HealthGrid a Global Initiative to Support the VPH Community , Yannick Legre (HealthGrid)
12.00 The VPH Toolkit - Challenges, Standards and Protocols for VPH Interoperability, Sharon Lloyd (Univ. of Oxford)
12.30 Interactive Discussion
13.00 Lunch
14.00 Industry Meeting Closes
spacer
spacer