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Integration of Genomic Information Related to Crop Diseases and Pests Workshop

20 - 21 October 2008

Dear Associates,

The EBI will host a Integration of Genomic Information Related to Crop Diseases and Pests Workshop on the 20th to 21st October 2008.

The venue will be Room M203, Murray's Building on the 20th October and the EBI IT Training room on the 21st October.

We would like to invite you to attend a meeting hosted by the European Bioinformatics Institute focussing on the Agricultural sector. The meeting aims to identify how the commercial and academic opportunities afforded by the sequencing revolution can be realised. The workshop will take place on 20th to 21st October 2008 at EMBL-EBI. It will start mid morning of 20th October and end with lunch on 21st October. See initial agenda below.

Motivation:

Advances in the understanding of crop pest and disease management have direct bearing on sustainable crop production. Information derived from biomolecular studies builds up our understanding of the life processes of these pests and pathogens. This knowledge is a potent force for the discovery of novel approaches to protect our crops from damage and thereby to increase farm production.

The past four years has seen the production of genome sequence assemblies for numerous eukaryotic plant pathogens and invertebrate species closely related to major pests. With the advent of cheaper sequencing technologies comes the prospect of genome sequences being derived for an ever greater number of pest species and key variant strains. Given the great economic and social value of these species, determining their genetic code is certainly a great step forward for research. Extracting value from these data in terms of building understanding of the comparative biochemical systems in these species is a major undertaking. It is clear that co-ordination of the comparative annotation of their genomic information will be absolutely required to attain breakthroughs in research goals.

Strategic funding of the delivery of genomic information of relevance to the biomedical sector has resulted in the production of the Ensembl environment. Ensembl’s technical capabilities have enabled the comparative annotation of a large number of vertebrate species. Ensembl’s view of collated genomic information has become a de facto standard from which life scientists can draw value from reference genome sequences. With the rising tide of genomic information relating to pest species, it is viewed that an equal endeavour should now be applied to genomes of relevance to the Agricultural sector.

It is of long term strategic importance to European Agricultural research and farm production that:
• The genomic information of a wide range of major invertebrate pests and eukaryotic pathogens be readily accessible to bioscientists working in academia and commercial organisations
• Universal standards of annotation are established for the taxonomic groups so as to provide high quality comparisons of conserved genes and pathways between related species.
• New functional annotation and gene structures across comparative species are proactively produced, collated and maintained.
• Genome-wide annotation revisions are enabled as additional large scale data is produced.
• Information relating to variation of strains is integrated.

The meeting will be held at the European Bioinformatics Institute between interested parties from academia, commercial enterprise and industry.

Purpose:

The purpose of this meeting will be:
• To identify the strategic information requirements of European research organisations conducting biomolecular studies and genomic analyses of these species.
• To draw upon the experience gained from the delivery of vertebrate genomes for the biomedical sector to identify synergies with the challenges faced by the Agricultural sector.
• To co-create a vision for the strategic delivery of these genomes and their comparative annotation.
• To discuss the process for producing funding proposals addressing the means by which this vision can be delivered.

Key discussion topics include:

• What approaches are currently being made in the community to create reference annotation of genome sequences of invertebrate pest and fungal crop pathogens?
• What endeavours are underway to produce high quality of gene calls and functional assignments in these species? Are there ways of sharing best practise?
• How can knowledge about the genes involved in key biochemical and physiological pathways be accessed?
• To what extent is the genome annotation of these species dependent on on-going annotation of model species and cross species comparisons as new sequences are produced?
• Are there synergies between genomic information analysis, delivery and maintenance for the biomedical sector and agricultural sector? Are there significant differences?
• Should the delivery of the genomic information for these species be co-ordinated, what would be the additional benefits to the research community?

Organisers and contacts:

The Coordinator of the EBI Industry Programme is Dr. Dominic Clark (EMBL-EBI). Please send any questions regarding the strategic intent and programme to Dominic Clark (clark@ebi.ac.uk).

We are grateful to Dr. Michael Csukai and Dr Katie Cook (Syngenta Ltd) to Prof. Chris Rawlings (Rothamsted Research) and to representatives of the BBSRC for helpful input on the programme and agenda.

Please send any questions regarding logistics to Liz Ford (ford@ebi.ac.uk).

Agenda:

Time Agenda
Monday 20 October 2008
10.45 Registration Tea/Coffee
11.15 Wellcome and Background to Meeting, Graham Cameron & Dr. Dominic Clark, EMBL-EBI View PDF
11.20 Setting the Scene, Dr Michael Csukai, Syngenta Ltd View PDF
11.50 ENSEMBL for plants and phytopathogens, Dr Paul Kersey, EMBL-EBI View PDF
12.20 Comparative and Evolutionary Genomics of Plant Pathogenic Fungi, Darren Soanes, University of Exeter View PDF
12.50 Discussion
13.00 Lunch
14.10 Sequencing the Barley powdery mildew genome (http://www.blugen.org/) Pietro Spanu (Imperial College) View PDF
14.35 Annotation of the Genomes of Botrytis cinerea and Leptosphaeria maculans and research on understanding the infection process, Dr Marc-Henri LEBRUN (Bayer Crop Science) View PDF
15.00 Annotation of the Genome of Leptosphaeria maculans and research on understanding the infection process, Dr. Thierry Rouxel, (INRA) View PDF
15.25 Data integration and Annotation at URGI, an INRA Bioinformatic Platform for Plant and Pest genomicsHadi Quesneville (INRA) View PDF
15.45 Tea/Coffee
16.15 Oomycete genomics to investigate virulence mechanisms and host specificity, Dr Eric Kemen (Sainsbury Laboratory) View PDF
16.35 The Plant Pathogen 'Omics world - where is it taking us?, Prof. Kim Hammond-Kosack, Rothamsted Research View PDF
17.10 Discussion and observations on the first day (discussants)
18.00 Close of First Day
18.30 Pre-dinner drinks, Hinxton Hall
19.00 Workshop Dinner, Conference Centre Restaurant, Hinxton
Tuesday 21 October 2008
09.00 Tea/Coffee
09.30 Pea Aphid Annotation, Denis Tagu (INRA) View PDF
10.00 Annotation of Hymenoptera Genomes, Dr. Christine Elsik, Department of Biology, (Georgetown University) View PDF
10.30 Discussion View PDF
10.40 QBOL: Development of a new diagnostic tool using DNA bar-coding to identify quarantine organisms in support of plant health, Dr Peter Bonants, Plant Research International, Wageningen View PDF
11.10 Tea/Coffee
11.30 Overview of activities and priorities of the UK Biotechnology and Biological Sciences Research Council, Dr Debbie Harding (BBSRC) View PDF
12.00 Interdisciplinary interactions with small molecules, plants, agriculture and environment, Dr mark Forster Syngenta & Chair of ELIXIR WP10 Committee 1 View PDF
12.30 Discussion on key topics, with short commentaries from discussants. Key outcomes and next steps
13.00 Lunch
14.00 Departures
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