E3 ubiquitin ligase of NEDD4 family; regulates many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, ribosome stability; mutant tolerates aneuploidy; autoubiquitinates; ubiquitinates Sec23p and Sna3p; deubiquitinated by Ubp2p; activity regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; human homolog implicated in Liddle syndrome

Synonyms MDP1, MUT2, NPI1, SMM1, UBY1
Gene Ontology
InterPro C2 domain (domain), HECT (domain), WW domain (domain), E3 ubiquitin-protein ligase, SMURF1 type (family)
Ensembl Gene YER125W
UniProt P39940
Gene Biotype protein_coding
Design Element 1779377_at, 5565_at