Expression Atlas results for ENSMUSG00000020063

    Sirt1 Mus musculus sirtuin 1
Synonyms Sir2, Sir2alpha
Orthologs SIRT1 (Bos taurus), SIRT1 (Canis familiaris), ENSCING00000015552 (Ciona intestinalis), ENSCSAVG00000003452 (Ciona savignyi), ENSCSAVG00000003454 (Ciona savignyi), sirt1 (Danio rerio), SIRT1 (Equus caballus), SIRT1 (Homo sapiens), SIRT1 (Gallus gallus), SIRT1 (Macaca mulatta), Sirt1 (Rattus norvegicus), SIRT1 (Sus scrofa), sirt1 (Xenopus tropicalis), Sir2 (Drosophila melanogaster), sir-2.1 (Caenorhabditis elegans), SIR2 (Saccharomyces cerevisiae), HST1 (Saccharomyces cerevisiae)
Gene Ontology single strand break repair, negative regulation of transcription from RNA polymerase II promoter, chromatin silencing at rDNA, pyrimidine dimer repair by nucleotide-excision repair, DNA synthesis involved in DNA repair, chromatin, nuclear chromatin, angiogenesis, ovulation from ovarian follicle, cellular glucose homeostasis, positive regulation of protein phosphorylation, p53 binding, positive regulation of adaptive immune response, transcription corepressor activity, histone deacetylase activity, protein binding, nucleus, nuclear envelope, nuclear inner membrane, nucleoplasm, chromatin silencing complex, nuclear euchromatin, nuclear heterochromatin, nucleolus, cytoplasm, mitochondrion, chromatin organization, establishment of chromatin silencing, maintenance of chromatin silencing, transcription, DNA-templated, rRNA processing, protein deacetylation, triglyceride mobilization, cellular response to DNA damage stimulus, response to oxidative stress, spermatogenesis, regulation of mitotic cell cycle, muscle organ development, protein C-terminus binding, transcription factor binding, positive regulation of cell proliferation, intrinsic apoptotic signaling pathway in response to DNA damage, cellular response to starvation, positive regulation of cholesterol efflux, regulation of glucose metabolic process, positive regulation of macroautophagy, protein ubiquitination, histone deacetylation, PML body, NAD-dependent histone deacetylase activity, peptidyl-lysine acetylation, deacetylase activity, enzyme binding, protein domain specific binding, negative regulation of cell growth, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of prostaglandin biosynthetic process, protein destabilization, response to nutrient levels, positive regulation of chromatin silencing, negative regulation of TOR signaling, regulation of endodeoxyribonuclease activity, negative regulation of NF-kappaB transcription factor activity, response to insulin, regulation of protein import into nucleus, translocation, rDNA heterochromatin, protein deacetylase activity, regulation of smooth muscle cell apoptotic process, NAD-dependent protein deacetylase activity, peptidyl-lysine deacetylation, ESC/E(Z) complex, cellular triglyceride homeostasis, regulation of peroxisome proliferator activated receptor signaling pathway, regulation of cell proliferation, negative regulation of phosphorylation, histone binding, response to hydrogen peroxide, cholesterol homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, identical protein binding, positive regulation of apoptotic process, negative regulation of apoptotic process, negative regulation of I-kappaB kinase/NF-kappaB signaling, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, HLH domain binding, bHLH transcription factor binding, negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of MHC class II biosynthetic process, negative regulation of fat cell differentiation, positive regulation of DNA repair, negative regulation of transcription, DNA-templated, positive regulation of transcription from RNA polymerase II promoter, positive regulation of insulin receptor signaling pathway, metal ion binding, NAD-dependent histone deacetylase activity (H3-K9 specific), white fat cell differentiation, mitogen-activated protein kinase binding, negative regulation of helicase activity, positive regulation of histone H3-K9 methylation, negative regulation of protein kinase B signaling, fatty acid homeostasis, negative regulation of androgen receptor signaling pathway, cellular response to hydrogen peroxide, NAD+ binding, regulation of bile acid biosynthetic process, histone H3 deacetylation, cellular response to tumor necrosis factor, cellular response to hypoxia, cellular response to ionizing radiation, negative regulation of neuron death, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress, keratin filament binding, positive regulation of macrophage apoptotic process, negative regulation of cAMP-dependent protein kinase activity, positive regulation of cAMP-dependent protein kinase activity, negative regulation of cellular response to testosterone stimulus, negative regulation of peptidyl-lysine acetylation, negative regulation of cellular senescence, positive regulation of cellular senescence
InterPro Sirtuin family (family), Sirtuin family, catalytic core domain (domain), DHS-like NAD/FAD-binding domain (domain)
Ensembl Gene ENSMUSG00000020063
Entrez 93759
UniProt F6YAQ3, Q3UNI1, Q3USJ2, Q3USY7, Q53Z05, Q923E4
EMAGE MGI:2135607
MGI sirtuin 1
Gene Biotype protein_coding
Design Element 10369738, 111531_at, 115059_at, 1418640_at, 4314274, 4347990, 4359481, 4381779, 4384877, 4554421, 4562215, 4645704, 4649340, 4684892, 4804148, 5052557, 5102287, 5184515, 5223304, 5232810, 5234347, 5352978, 5404804, 5502505, 5524143, 5547537, A_51_P141152, A_52_P358612, A_55_P2030428
    Baseline Expression Results in tissues
c Expression Level cut-off: 0.5
    Differential Expression 16 results
Showing 16 results cutoffs: adjusted p-value 0.05    log2-fold change 1.0