Expression Atlas results for ENSG00000188906

    LRRK2 Homo sapiens leucine-rich repeat kinase 2
Synonyms DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2
Orthologs LRRK2 (Bos taurus), LRRK2 (Canis familiaris), ENSCING00000011837 (Ciona intestinalis), LRRK2 (1 of 2) (Danio rerio), LRRK2 (2 of 2) (Danio rerio), LRRK2 (Equus caballus), LRRK2 (Gallus gallus), LRRK2 (Macaca mulatta), Lrrk2 (Mus musculus), Lrrk2 (Rattus norvegicus), LRRK2 (Sus scrofa), lrrk2 (Xenopus tropicalis), FBgn0038816 (Drosophila melanogaster), lrk-1 (Caenorhabditis elegans)
Gene Ontology SNARE binding, MAPK cascade, activation of MAPKK activity, activation of MAPK activity, negative regulation of protein phosphorylation, positive regulation of protein phosphorylation, glycoprotein binding, molecular function, actin binding, GTPase activity, protein kinase activity, protein serine/threonine kinase activity, MAP kinase kinase activity, protein tyrosine kinase activity, GTPase activator activity, binding, protein binding, ATP binding, GTP binding, cellular component, extracellular space, intracellular, cytoplasm, mitochondrion, mitochondrial outer membrane, mitochondrial inner membrane, mitochondrial matrix, lysosome, endosome, vacuole, endoplasmic reticulum, Golgi apparatus, trans-Golgi network, cytosol, plasma membrane, GTP catabolic process, cellular protein modification process, protein phosphorylation, transport, endocytosis, autophagy, response to stress, response to oxidative stress, mitochondrion organization, signal transduction, small GTPase mediated signal transduction, neuromuscular junction development, synaptic vesicle, cytoskeletal protein binding, biological process, cell death, determination of adult lifespan, catabolic process, positive regulation of autophagy, regulation of protein kinase A signaling, negative regulation of protein processing, regulation of neuron maturation, protein transport, tubulin binding, membrane, vesicle-mediated transport, inclusion body, kinase activity, transferase activity, transferring phosphorus-containing groups, Rho GTPase binding, syntaxin-1 binding, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, enzyme binding, olfactory bulb development, tangential migration from the subventricular zone to the olfactory bulb, enzyme regulator activity, clathrin binding, axon, dendrite, positive regulation of protein ubiquitination, cytoplasmic vesicle, mitochondrial membrane, negative regulation of protein binding, positive regulation of protein binding, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, cytoplasmic side of mitochondrial outer membrane, dendrite cytoplasm, GTP-dependent protein kinase activity, negative regulation of GTPase activity, cellular response to oxidative stress, cellular protein localization, cellular nitrogen compound metabolic process, nucleobase-containing compound catabolic process, intracellular signal transduction, regulation of kidney size, exploration behavior, locomotory exploration behavior, locomotion, regulation of locomotion, regulation of membrane potential, identical protein binding, protein homodimerization activity, neuron projection, neuronal cell body, positive regulation of programmed cell death, ion binding, terminal bouton, perikaryon, organelle, intracellular membrane-bounded organelle, positive regulation of MAP kinase activity, positive regulation of GTPase activity, small molecule metabolic process, ion channel binding, membrane raft, synapse, protein autophosphorylation, intracellular distribution of mitochondria, neuron projection morphogenesis, anatomical structure development, cell motility, protein kinase A binding, regulation of mitochondrial depolarization, regulation of synaptic transmission, glutamatergic, regulation of excitatory postsynaptic membrane potential, regulation of dopamine receptor signaling pathway, positive regulation of dopamine receptor signaling pathway, regulation of dendritic spine morphogenesis, extracellular vesicular exosome, protein localization to mitochondrion, neuron death, cellular response to manganese ion, cellular response to organic cyclic compound, reactive oxygen species metabolic process, regulation of mitochondrial fission, regulation of neuron death, positive regulation of protein autoubiquitination, regulation of neuroblast proliferation, regulation of synaptic vesicle transport, negative regulation of late endosome to lysosome transport, negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation, regulation of branching morphogenesis of a nerve, regulation of synaptic vesicle exocytosis, negative regulation of peroxidase activity
InterPro Protein kinase domain (domain), Serine-threonine/tyrosine-protein kinase catalytic domain (domain), Leucine-rich repeat (repeat), Small GTPase superfamily (family), Serine/threonine/dual specificity protein kinase, catalytic domain (domain), Small GTPase superfamily, Rab type (family), Leucine-rich repeat, typical subtype (repeat), Small GTP-binding protein domain (domain), Small GTPase superfamily, ARF/SAR type (family), Protein kinase-like domain (domain), Mitochondrial Rho-like (domain), Armadillo-type fold (domain), WD40-repeat-containing domain (domain), Tyrosine-protein kinase, catalytic domain (domain), Ankyrin repeat-containing domain (domain), P-loop containing nucleoside triphosphate hydrolase (domain)
Ensembl Gene ENSG00000188906
Entrez 120892
UniProt A2VED2, C9JBF0, E9PC85, Q5S007
Gene Biotype protein_coding
Design Element 229584_at, 3411325, 3411329, 3411330, 3411332, 3411333, 3411335, 3411336, 3411337, 3411341, 3411343, 3411344, 3411345, 3411346, 3411347, 3411348, 3411349, 3411350, 3411351, 3411354, 3411355, 3411356, 3411357, 3411358, 3411360, 3411361, 3411362, 3411363, 3411364, 3411365, 3411366, 3411367, 3411368, 3411369, 3411370, 3411371, 3411372, 3411373, 3411374, 3411376, 3411377, 3411379, 3411380, 3411381, 3411383, 3411385, 3411386, 3411389, 3411391, 3411392, 3411394, 3411396, 3411397, 3411398, 3411399, 3411402, 3411404, 3411405, 3411407, 3411408, 3411409, 3411410, 3411411, 3411412, 3411413, 3411414, 3411415, 51362_at, 7954810, 81790_at, A_23_P128447, A_33_P3369058, A_33_P3389872, Hs.124292.0.A1_3p_at
    Baseline Expression Results in tissues
c Expression Level cut-off: 0.5
    Differential Expression 48 results
Showing 48 results cutoffs: adjusted p-value 0.05    log2-fold change 1.0