Expression Atlas results for ENSG00000145335

    SNCA Homo sapiens synuclein, alpha (non A4 component of amyloid precursor)
Synonyms NACP, PARK1, PARK4, PD1, alpha-synuclein
Orthologs SNCA (Bos taurus), SNCA (Canis familiaris), SNCA (Equus caballus), SNCA (Gallus gallus), SNCA (Macaca mulatta), Snca (Mus musculus), Snca (Rattus norvegicus), SNCA (Sus scrofa), snca (Xenopus tropicalis)
Gene Ontology negative regulation of transcription from RNA polymerase II promoter, magnesium ion binding, microglial cell activation, positive regulation of receptor recycling, negative regulation of protein phosphorylation, positive regulation of neurotransmitter secretion, synaptic transmission, dopaminergic, immune system process, molecular function, DNA binding, copper ion binding, calcium ion binding, protein binding, phospholipid binding, cellular component, extracellular region, nucleus, nuclear outer membrane, cytoplasm, mitochondrion, mitochondrial respiratory chain complex I, lysosome, vacuole, rough endoplasmic reticulum, Golgi apparatus, cytosol, ribosome, cytoskeleton, plasma membrane, cell cortex, fatty acid metabolic process, neutral lipid metabolic process, phospholipid metabolic process, transport, activation of cysteine-type endopeptidase activity involved in apoptotic process, response to stress, mitochondrial membrane organization, synaptic transmission, aging, microtubule binding, synaptic vesicle, cytoskeletal protein binding, biological process, ferrous iron binding, zinc ion binding, lipid binding, adult locomotory behavior, biosynthetic process, response to iron(II) ion, regulation of phospholipase activity, negative regulation of platelet-derived growth factor receptor signaling pathway, regulation of glutamate secretion, regulation of dopamine secretion, actin cytoskeleton, vesicle-mediated transport, inclusion body, oxidoreductase activity, kinesin binding, enzyme binding, protein domain specific binding, cell junction, extracellular matrix organization, enzyme regulator activity, axon, growth cone, Hsp70 protein binding, cytoplasmic vesicle membrane, platelet alpha granule membrane, negative regulation of microtubule polymerization, receptor internalization, protein destabilization, response to magnesium ion, negative regulation of transporter activity, response to lipopolysaccharide, negative regulation of monooxygenase activity, positive regulation of peptidyl-serine phosphorylation, response to interferon-gamma, cellular response to oxidative stress, negative regulation of histone acetylation, synaptic vesicle recycling, regulation of locomotion, response to cocaine, histone binding, dopamine biosynthetic process, dopamine metabolic process, response to drug, mitochondrial ATP synthesis coupled electron transport, identical protein binding, alpha-tubulin binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, regulation of macrophage activation, positive regulation of apoptotic process, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, ion binding, terminal bouton, fibril, extracellular fibril organization, organelle, intracellular membrane-bounded organelle, protein complex, phospholipase binding, negative regulation of neuron apoptotic process, axon terminus, transcription regulatory region DNA binding, cellular response to fibroblast growth factor stimulus, synapse, dynein binding, positive regulation of endocytosis, negative regulation of exocytosis, negative regulation of dopamine metabolic process, regulation of neurotransmitter secretion, protein N-terminus binding, behavioral response to cocaine, tau protein binding, regulation of neuronal synaptic plasticity, regulation of long-term neuronal synaptic plasticity, perinuclear region of cytoplasm, beta-tubulin binding, synaptic vesicle endocytosis, synaptic vesicle transport, arachidonic acid binding, positive regulation of synaptic transmission, synapse organization, regulation of acyl-CoA biosynthetic process, phosphoprotein binding, positive regulation of release of sequestered calcium ion into cytosol, dopamine uptake involved in synaptic transmission, negative regulation of dopamine uptake involved in synaptic transmission, protein maturation, negative regulation of serotonin uptake, negative regulation of norepinephrine uptake, oxidation-reduction process, regulation of excitatory postsynaptic membrane potential, long-term synaptic potentiation, positive regulation of inositol phosphate biosynthetic process, membrane organization, negative regulation of thrombin receptor signaling pathway, response to interleukin-1, cellular response to copper ion, cellular response to epinephrine stimulus, positive regulation of protein serine/threonine kinase activity, regulation of neuron death, negative regulation of mitochondrial electron transport, NADH to ubiquinone, regulation of reactive oxygen species metabolic process
InterPro Synuclein (family), Alpha-synuclein (family), Gamma-synuclein (family)
Ensembl Gene ENSG00000145335
Entrez 6622
UniProt D6RA31, E7EPV7, F6L6N6, H6UYS0, H6UYS5, H6UYS7, P37840, Q4W5L2
Gene Biotype protein_coding
Design Element 204466_s_at, 204467_s_at, 207827_x_at, 211546_x_at, 236081_at, 2777711, 2777712, 2777715, 2777716, 2777717, 2777718, 2777719, 2777722, 2777742, 2777743, 2777744, 2777746, 2777749, 2777750, 2777751, 2777752, 2777753, 2777754, 2777756, 3468050, 37291_r_at, 44191_at, 8101762, A_23_P29939, A_32_P109653, Hs.21374.0.A1_3p_at, Hs.76930.1.A1_3p_a_at, U46901_at, g556211_3p_x_at, g556213_3p_a_at, g6806896_3p_a_at
    Baseline Expression Results in tissues
c Expression Level cut-off: 0.5
    Differential Expression 52 results
Showing 50 of 52 results cutoffs: adjusted p-value 0.05    log2-fold change 1.0