Expression Atlas results for ENSG00000135679

    MDM2 Homo sapiens MDM2 proto-oncogene, E3 ubiquitin protein ligase
Synonyms HDM2, MGC5370
Orthologs MDM2 (Bos taurus), MDM2 (Canis familiaris), ENSCING00000001188, ENSCSAVG00000011522 (Ciona savignyi), mdm2 (Danio rerio), MDM2 (Equus caballus), MDM2 (Gallus gallus), MDM2 (Macaca mulatta), Mdm2 (Mus musculus), Mdm2 (Rattus norvegicus), MDM2 (Sus scrofa), mdm2 (Xenopus tropicalis)
Gene Ontology negative regulation of transcription from RNA polymerase II promoter, p53 binding, immune system process, molecular function, ubiquitin-protein transferase activity, protein binding, cellular component, nucleus, nucleoplasm, nucleolus, cytoplasm, cytosol, plasma membrane, protein complex assembly, cellular protein modification process, response to stress, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, traversing start control point of mitotic cell cycle, signal transduction, epidermal growth factor receptor signaling pathway, cell-cell signaling, synaptic transmission, biological process, zinc ion binding, positive regulation of cell proliferation, fibroblast growth factor receptor signaling pathway, response to toxic substance, response to carbohydrate, response to iron ion, positive regulation of gene expression, negative regulation of gene expression, negative regulation of protein processing, viral process, protein ubiquitination, nuclear body, ligase activity, peptidyl-lysine modification, enzyme binding, cellular component assembly, protein catabolic process, endocytic vesicle membrane, ubiquitin protein ligase binding, protein destabilization, response to magnesium ion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein localization to nucleus, Fc-epsilon receptor signaling pathway, regulation of protein catabolic process, response to cocaine, response to drug, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, identical protein binding, peroxisome proliferator activated receptor binding, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, ion binding, organelle, protein complex, response to morphine, negative regulation of DNA damage response, signal transduction by p53 class mediator, symbiosis, encompassing mutualism through parasitism, innate immune response, establishment of protein localization, synapse, response to ether, positive regulation of cell cycle, negative regulation of transcription, DNA-templated, positive regulation of mitotic cell cycle, response to antibiotic, positive regulation of protein export from nucleus, neurotrophin TRK receptor signaling pathway, phosphatidylinositol-mediated signaling, response to steroid hormone, macromolecular complex assembly, cellular response to hydrogen peroxide, negative regulation of cell cycle arrest, cellular response to acid, cellular response to antibiotic, cellular response to vitamin B1, cellular response to organic substance, cellular response to alkaloid, cellular response to growth factor stimulus, cellular response to peptide hormone stimulus, cellular response to estrogen stimulus, cellular response to organic cyclic compound, cellular response to hypoxia, cellular response to UV-C, scaffold protein binding
InterPro Zinc finger, RING-type (domain), Zinc finger, RanBP2-type (domain), SWIB/MDM2 domain (domain), p53 negative regulator Mdm2/Mdm4 (family)
Ensembl Family E3 UBIQUITIN LIGASE MDM2 EC_6.3.2.- DOUBLE MINUTE 2 P53 BINDING MDM2, UNKNOWN
Ensembl Gene ENSG00000135679
Entrez 4193
UniProt A7UKX7, A7UKX8, A7UKY0, A8WFP2, E5RHE2, E5RJQ0, E7EMW5, E7EPE2, F5GWH7, F5GZB0, F5GZC3, F5H1M7, F5H4Q8, F6RKA8, G3XA89, I6SST1, I6TMT6, I6TZT0, J3KN53, J3QST1, Q00987, Q546E6, Q8NDW1, Q8TE47, Q96DS5, Q9H4C3, Q9H4C5
Gene Biotype protein_coding
Design Element 1859_s_at, 1880_at, 2008_s_at, 205386_s_at, 211832_s_at, 217373_x_at, 217542_at, 217557_3p_s_at, 217557_s_at, 225160_x_at, 229711_s_at, 237891_at, 238733_at, 244616_3p_x_at, 244616_x_at, 3421301, 3421302, 3421303, 3421304, 3421305, 3421306, 3421307, 3421310, 3421311, 3421312, 3421313, 3421314, 3421315, 3421316, 3421317, 3421321, 3421322, 3421323, 3421325, 3421326, 3421334, 3421335, 3421336, 3421337, 3421338, 3421339, 3421340, 3421341, 3421342, 3421346, 3421347, 3421348, 3421349, 3421350, 3421351, 3421353, 3421361, 3421363, 3421365, 3421366, 3421368, 3421369, 3421371, 38509_at, 3979479, 46744_s_at, 53464_at, 62280_at, 64992_i_at, 64993_r_at, 75871_at, 7956989, A_23_P309545, A_23_P502750, A_24_P925664, A_33_P3361707, Hs.116932.0.A1_3p_at, Hs.166835.0.A1_3p_at, Hs.166835.0.A1_3p_x_at, Hs.168732.0.A1_3p_at, Hs.168732.0.A1_3p_x_at, Hs.267158.1.S1_3p_at, Hs.272346.0.S1_3p_s_at, Hs.332938.1.S1_3p_a_at, Hs.37494.0.A1_3p_at, M92424_at, U33202_s_at, U33203_s_at, g7230489_3p_s_at
    Baseline Expression Results in tissues
c Expression Level cut-off: 0.5
    Differential Expression 78 results
Showing 50 of 78 results cutoffs: adjusted p-value 0.05    log2-fold change 1.0