PTPRC
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Homo sapiens |
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PTPRC is differentially expressed in 300 experiments: 144 organism parts: thymus, lung, ... (142 more);, 312 disease states: normal, control, ... (310 more);, 122 cell types 416 cell lines 29 compound treatments and 73 other conditions. |
| Synonyms |
LCA, CD45, GP180, T200 |
| Orthologs |
ptprc
(Danio rerio)
PTPRC
(Bos taurus)
PTPRC
(Gallus gallus)
Ptprc
(Rattus norvegicus)
Ptprc
(Mus musculus)
ENSCING00000006783
(Ciona intestinalis)
ptprc
(Xenopus laevis)
PTPRC
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0009897, GO:0008201, GO:0009986, GO:0016021, GO:0010332, GO:0007166, GO:0016311, GO:0007411, GO:0005925, GO:0051209, GO:0016791, GO:0016787, GO:0004725, GO:0005515, GO:0004872, GO:0005886, GO:0005887, GO:0042981, GO:0043065, GO:0019901, GO:0050732, GO:0006470, GO:0006469, GO:0000187, GO:0051726, GO:0043395, GO:0045860, GO:0051607, GO:0045121, GO:0033261, GO:0034113, GO:0007159, GO:0031953, GO:0002711, GO:0048304, GO:0002378, GO:0030890, GO:0005001, GO:0001960, GO:0050857, GO:0050855, GO:0050852, GO:0050853, GO:0042102, GO:0042100, GO:0001915, GO:0001916, GO:0045577, GO:0045588, GO:0045582, GO:0042098, GO:0046641, GO:0043410, GO:0035335, GO:0030183, GO:0002923, GO:0002925, GO:0030217, GO:0045060, GO:0045059 |
| Gene Ontology Term |
focal adhesion, defense response to virus, plasma membrane, phosphatase activity, regulation of S phase, protein binding, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein kinase activity, heparin binding, dephosphorylation, heparan sulfate proteoglycan binding, membrane raft, positive regulation of apoptosis, external side of plasma membrane, activation of MAPK activity, positive regulation of protein kinase activity, protein tyrosine phosphatase activity, axon guidance, regulation of cell cycle, cell surface receptor linked signaling pathway, protein kinase binding, integral to plasma membrane, receptor activity, integral to membrane, hydrolase activity, cell surface, response to gamma radiation, release of sequestered calcium ion into cytosol, regulation of apoptosis, positive regulation of alpha-beta T cell proliferation, negative regulation of cytokine-mediated signaling pathway, B cell differentiation, T cell receptor signaling pathway, positive regulation of B cell proliferation, regulation of B cell differentiation, B cell receptor signaling pathway, negative thymic T cell selection, B cell proliferation, peptidyl-tyrosine dephosphorylation, positive regulation of T cell mediated immunity, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of gamma-delta T cell differentiation, T cell proliferation, immunoglobulin biosynthetic process, heterotypic cell-cell adhesion, regulation of B cell receptor signaling pathway, positive regulation of T cell mediated cytotoxicity, positive regulation of isotype switching to IgG isotypes, positive regulation of T cell differentiation, leukocyte cell-cell adhesion, positive regulation of T cell proliferation, transmembrane receptor protein tyrosine phosphatase activity, positive regulation of MAPKKK cascade, T cell differentiation, positive thymic T cell selection, positive regulation of antigen receptor-mediated signaling pathway, negative regulation of T cell mediated cytotoxicity, regulation of humoral immune response mediated by circulating immunoglobulin, protein dephosphorylation, negative regulation of protein autophosphorylation |
| InterPro ID |
IPR003961, IPR000242, IPR000387, IPR003595, IPR016335, IPR024739 |
| InterPro Term |
Tyr_Pase_cat, Tyr_Pase_rcpt/non-rcpt, Tyr/Dual-specificity_Pase, Fibronectin_type3, Leukocyte_common_ag, PTP_recept_N |
| Ensembl Family Description |
RECEPTOR TYPE TYROSINE PHOSPHATASE C PRECURSOR EC_3.1.3.48 LEUKOCYTE COMMON ANTIGEN L CA T200 CD45 ANTIGEN |
| Ensembl Family |
ENSFM00570000851267 |
| EMBL-Bank ID |
BC148257, M29253, AL355988, BC127656, BC127657, AY539683, AY539691, AY539675, AY539699, Y00062, AY539667, AY539659, BC017863, AL157402, CH471067, Y00638, M23486, M23487, M23484, M23485, M23488, M23489, M23482, M23483, M23480, M23481, M23496, M23490, M23491, M23492, M23466, M23467, M23462, M23463, M23461, M23476, M23477, M23478, M23479, M23472, M23473, M23474, M23475, M23470, M23471, M23469, M23468, AK292131, BC121087, BC121086, AY567999 |
| Ensembl Protein ID |
ENSP00000306782, ENSP00000193532, ENSP00000411355, ENSP00000405494, ENSP00000271610, ENSP00000356337, ENSP00000356334, ENSP00000356336, ENSP00000356349, ENSP00000356346, ENSP00000393360, ENSP00000444735, ENSP00000433536 |
| UniProt Accession |
Q9H3X6, Q0VAE8, Q6LDN6, Q6QIN9, Q6QIN1, Q6QIM3, Q6QIR3, Q6QIQ5, Q5T9L9, Q5T9M3, Q5T9M5, Q5T9M0, Q5T9M2, P08575, B1ALS1, B1ALS2, B1ALS3, F5GZM5, E9PMF7, E9PMF8, E9PMG0, E9PPL9, F5GXZ3, Q6Q1P2, E9PC28, E9PKH0, F5H547 |
| UniGene ID |
Hs.599730, Hs.654514 |
| Gene-Disease Assocation |
SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE,, HEPATITIS C VIRUS, SUSCEPTIBILITY TO, MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO; MS |
| RefSeq ID |
NM_080921, NM_080923, NP_002829, NP_563578, NP_563580, NM_002838 |
| Ensembl Gene ID |
ENSG00000081237 |
| Description |
protein tyrosine phosphatase, receptor type, C [Source:HGNC Symbol;Acc:9666] |
| HGNC Symbol |
PTPRC |
| Entrez Gene ID |
5788 |
| Ensembl Transcript ID |
ENST00000530727, ENST00000442510, ENST00000391970, ENST00000352140, ENST00000271610, ENST00000367367, ENST00000367366, ENST00000367376, ENST00000367364, ENST00000367379, ENST00000427110, ENST00000418674, ENST00000462363, ENST00000484135, ENST00000348564, ENST00000529828, ENST00000535566, ENST00000413409, ENST00000491302 |
| Design Element |
Hs2.170121.1.A1_3p_at, 1552480_s_at, Y00062_at, 58587_at, ENST00000529828, ENST00000413409, 212587_s_at, 212588_at, ENST00000367366, Hs2.170121.1.A1_3p_s_at, ENST00000367367, Hs.170121.1.A3_3p_at, ENST00000484135, g4506306_3p_a_at, ENST00000367364, Hs.170121.1.A1_3p_a_at, 40520_g_at, ENST00000462363, 1552480_3p_s_at, ENST00000535566, 239467_at, ENST00000271610, ENST00000530727, Hs.89257.0.A1_3p_at, ENST00000348564, 56668_at, ENST00000442510, ENST00000491302, 40518_at, ENST00000427110, ENST00000391970, 1569830_at, Hs2.382632.1.S1_3p_at, ENST00000367379, ENST00000367376, ENST00000352140, ENST00000418674, 207238_s_at |
| Search EB-eye |
ENSG00000081237
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