MAP3K8
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Homo sapiens |
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MAP3K8 is differentially expressed in 264 experiments: 101 organism parts: kidney, lung, ... (99 more);, 133 disease states: normal, lung adenocarcinoma, ... (131 more);, 66 cell types 284 cell lines 40 compound treatments and 62 other conditions. |
| Synonyms |
c-COT, ESTF, EST, MEKK8, COT, Tpl-2 |
| Orthologs |
MAP3K8
(Gallus gallus)
MAP3K8
(Danio rerio)
A5PK86_BOVIN
(Bos taurus)
Map3k8
(Mus musculus)
BCK1
(Saccharomyces cerevisiae)
Map3k8
(Rattus norvegicus)
map3k8
(Xenopus laevis)
MAP3K8
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR020635 |
| Gene Ontology Term |
cytosol, protein binding, cytoplasm, MAP kinase kinase kinase activity, protein tyrosine kinase activity, ATP binding, cell cycle, magnesium ion binding, nucleotide binding, kinase activity, protein serine/threonine kinase activity, signal transduction, protein kinase activity, T cell costimulation, protein phosphorylation |
| Gene Ontology ID |
GO:0007049, GO:0007165, GO:0016301, GO:0004709, GO:0004713, GO:0005524, GO:0005515, GO:0005737, GO:0005829, GO:0004672, GO:0004674, GO:0006468, GO:0000166, GO:0000287, GO:0031295 |
| InterPro Term |
Prot_kinase_cat_dom, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00260000051376 |
| Ensembl Family Description |
MITOGEN ACTIVATED KINASE KINASE KINASE 8 EC_2.7.11.25 CANCER OSAKA THYROID ONCOGENE PROTO ONCOGENE C COT SERINE/THREONINE KINASE COT |
| RefSeq ID |
NM_005204, NP_005195, NP_001231063, NM_001244134 |
| Ensembl Protein ID |
ENSP00000391275, ENSP00000409653, ENSP00000263056, ENSP00000411580, ENSP00000364470, ENSP00000364471, ENSP00000364477, ENSP00000443610 |
| EMBL-Bank ID |
AL161651, BC104833, AY309013, AK290320, CH471072, BC113566, AF133211, D14497, Z14138 |
| Description |
mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:6860] |
| Entrez Gene ID |
1326 |
| Ensembl Gene ID |
ENSG00000107968 |
| UniProt Accession |
P41279, Q5T857, Q5T856, Q5T854, Q5T853 |
| HGNC Symbol |
MAP3K8 |
| Gene-Disease Assocation |
LUNG CANCER |
| Ensembl Transcript ID |
ENST00000375321, ENST00000375322, ENST00000375328, ENST00000542547, ENST00000263056, ENST00000430603, ENST00000415139, ENST00000413724 |
| Design Element |
1891_at, ENST00000375321, 34770_at, 205027_s_at, ENST00000542547, ENST00000375328, ENST00000415139, ENST00000375322, ENST00000430603, D14497_at, ENST00000413724, 69820_at, g4885146_3p_a_at, ENST00000263056 |
| Search EB-eye |
ENSG00000107968
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