MAPK8
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Homo sapiens |
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MAPK8 is differentially expressed in 296 experiments: 132 organism parts: bone marrow, cerebellum, ... (130 more);, 199 disease states: normal, breast carcinoma, ... (197 more);, 98 cell types 422 cell lines 37 compound treatments and 76 other conditions. |
| Synonyms |
JNK, SAPK1, PRKM8, JNK1 |
| Orthologs |
HOG1
(Saccharomyces cerevisiae)
Q4H3A2_CIOIN
(Ciona intestinalis)
Mapk8
(Mus musculus)
MAPK8
(Bos taurus)
MAPK8
(Gallus gallus)
MK08_RAT
(Rattus norvegicus)
mapk8
(Xenopus laevis)
MAPK8
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR018934, IPR002575, IPR001245, IPR017442, IPR000719, IPR008351, IPR020635, IPR010440 |
| Gene Ontology Term |
response to UV, Toll signaling pathway, cytosol, JUN kinase activity, protein binding, apoptosis, phosphotransferase activity, alcohol group as acceptor, JUN phosphorylation, cytoplasm, peptidyl-serine phosphorylation, innate immune response, membrane, negative regulation of apoptosis, response to stress, protein tyrosine kinase activity, stress-activated MAPK cascade, regulation of protein localization, MAP kinase activity, histone deacetylase binding, response to cadmium ion, ATP binding, transferase activity, transferring phosphorus-containing groups, nucleus, nucleotide binding, kinase activity, protein serine/threonine kinase activity, JNK cascade, nucleoplasm, catalytic activity, peptidyl-threonine phosphorylation, lipopolysaccharide biosynthetic process, protein kinase activity, mitochondrion, toll-like receptor 4 signaling pathway, activation of pro-apoptotic gene products, negative regulation of protein binding, toll-like receptor signaling pathway, cellular response to mechanical stimulus, induction of apoptosis by intracellular signals, ossification, positive regulation of deacetylase activity, toll-like receptor 3 signaling pathway, induction of apoptosis by extracellular signals, nerve growth factor receptor signaling pathway, toll-like receptor 2 signaling pathway, induction of apoptosis in response to chemical stimulus, MyD88-dependent toll-like receptor signaling pathway, histone deacetylase regulator activity, protein phosphorylation, MyD88-independent toll-like receptor signaling pathway, regulation of sequence-specific DNA binding transcription factor activity, regulation of histone deacetylation, positive regulation of determination of dorsal identity, toll-like receptor 1 signaling pathway |
| Gene Ontology ID |
GO:0016020, GO:0008063, GO:0003824, GO:0009411, GO:0007254, GO:0007258, GO:0016301, GO:0051403, GO:0051090, GO:0016773, GO:0016772, GO:0004705, GO:0004707, GO:0004713, GO:0005524, GO:0005515, GO:0006915, GO:0006950, GO:0005737, GO:0005739, GO:0005634, GO:0005654, GO:0042826, GO:0005829, GO:0004672, GO:0004674, GO:0043066, GO:0006468, GO:0000166, GO:0018105, GO:0018107, GO:0032880, GO:0046686, GO:0009103, GO:0045087, GO:0048011, GO:0034142, GO:0034138, GO:0034134, GO:0008629, GO:0008624, GO:0008633, GO:0002755, GO:0002224, GO:0090045, GO:0001503, GO:0031558, GO:0071260, GO:0035033, GO:0032091, GO:0002756, GO:0031063, GO:2000017, GO:0034130 |
| Ensembl Family Description |
MITOGEN ACTIVATED KINASE MAP KINASE MAPK EC_2.7.11.24 STRESS ACTIVATED KINASE C JUN N TERMINAL KINASE |
| InterPro Term |
Aminoglycoside_PTrfase, Prot_kinase_cat_dom, RIO-like_kinase, JNK_MAPK, LipoPS_kinase, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00460000244930 |
| Ensembl Protein ID |
ENSP00000363289, ENSP00000363294, ENSP00000363291, ENSP00000363297, ENSP00000363304, ENSP00000378974, ENSP00000387936, ENSP00000353483, ENSP00000397729, ENSP00000393223 |
| EMBL-Bank ID |
AC016397, DQ234352, BC130570, BC130572, U34822, AC074325, AK292523, CH471187, U35005, U35004, L26318, BC144063, AB451398, AB451271, AB451231 |
| Ensembl Gene ID |
ENSG00000107643 |
| UniProt Accession |
C9J762, A1L4K2, Q308M2, C9JWQ4, A6NF29, P45983 |
| RefSeq ID |
NP_620634, NP_620635, NP_620637, NP_002741, NM_002750, NM_139049, NM_139047, NM_139046 |
| Description |
mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:6881] |
| UniGene ID |
Hs.138211, Hs.522924 |
| Entrez Gene ID |
5599 |
| HGNC Symbol |
MAPK8 |
| Ensembl Transcript ID |
ENST00000469879, ENST00000360332, ENST00000469110, ENST00000476134, ENST00000482840, ENST00000426557, ENST00000395611, ENST00000471272, ENST00000429041, ENST00000459755, ENST00000374174, ENST00000374176, ENST00000374179, ENST00000374182, ENST00000374189, ENST00000432379 |
| Design Element |
ENST00000429041, 47790_at, 56901_at, ENST00000432379, 84382_at, ENST00000476134, Hs.267445.0.S2_3p_at, 2070_i_at, 49512_at, ENST00000374176, ENST00000374174, 2071_s_at, ENST00000469110, ENST00000374179, Hs.65228.0.A1_3p_at, g1463136_3p_s_at, ENST00000360332, 229664_at, 226046_at, ENST00000482840, 34006_s_at, 210671_x_at, U35005_s_at, ENST00000471272, ENST00000395611, Hs.267445.0.S1_3p_at, ENST00000374182, 226048_at, ENST00000469879, ENST00000459755, g1463136_3p_a_at, 210477_x_at, ENST00000374189, ENST00000426557, 49510_at |
| Search EB-eye |
ENSG00000107643
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