Jak2
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Rattus norvegicus |
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Jak2 is differentially expressed in 66 experiments: 41 organism parts: frontal cortex, kidney, ... (39 more);, 5 disease states: normal, BDL 7 days, ... (3 more);, 10 cell types 10 compound treatments 11 clinical treatments and 15 other conditions. |
| Orthologs |
F1NQU4_CHICK
(Gallus gallus)
Jak2
(Mus musculus)
jak2a
(Danio rerio)
JAK2
(Homo sapiens)
Q4H3A3_CIOIN
(Ciona intestinalis)
jak2b
(Danio rerio)
PR2
(Drosophila melanogaster)
jak2
(Xenopus laevis)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR000299, IPR001245, IPR017441, IPR017442, IPR000719, IPR019749, IPR000980, IPR008266, IPR020635, IPR011009, IPR016251, IPR020693 |
| Gene Ontology Term |
endomembrane system, cytosol, response to antibiotic, response to oxidative stress, positive regulation of nitric oxide biosynthetic process, elevation of cytosolic calcium ion concentration, negative regulation of DNA binding, protein binding, SH2 domain binding, cytoskeleton, cytokine-mediated signaling pathway, cytoplasm, histone binding, negative regulation of cell proliferation, positive regulation of cell proliferation, membrane, hormone-mediated signaling pathway, G-protein coupled receptor protein signaling pathway, protein tyrosine kinase activity, receptor binding, insulin receptor substrate binding, negative regulation of heart contraction, nuclear matrix, heme binding, membrane fraction, positive regulation of apoptosis, positive regulation of phosphoprotein phosphatase activity, activation of MAPKK activity, ATP binding, transferase activity, transferring phosphorus-containing groups, protein kinase binding, nucleus, nucleotide binding, protein serine/threonine kinase activity, acetylcholine receptor binding, JAK-STAT cascade, chromatin modification, non-membrane spanning protein tyrosine kinase activity, signal transduction, protein kinase activity, caveola, intracellular protein kinase cascade, positive regulation of cell-substrate adhesion, tumor necrosis factor-mediated signaling pathway, positive regulation of growth hormone receptor signaling pathway, mineralocorticoid receptor signaling pathway, response to hydroperoxide, neuroprotection, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of cell-cell adhesion, response to tumor necrosis factor, positive regulation of protein import into nucleus, translocation, histone kinase activity (H3-Y41 specific), axon regeneration, platelet-derived growth factor receptor signaling pathway, erythrocyte differentiation, positive regulation of DNA binding, growth hormone receptor binding, positive regulation of cell migration, histone H3-Y41 phosphorylation, positive regulation of insulin secretion, interleukin-12 receptor binding, tyrosine phosphorylation of Stat1 protein, positive regulation of tyrosine phosphorylation of Stat5 protein, positive regulation of cell differentiation, growth hormone receptor signaling pathway, positive regulation of inflammatory response, induction of apoptosis by oxidative stress, regulation of inflammatory response, response to interleukin-12, positive regulation of interleukin-1 beta production, positive regulation of cell activation, peptide hormone receptor binding, enzyme linked receptor protein signaling pathway, activation of JAK2 kinase activity, JAK-STAT cascade involved in growth hormone signaling pathway, tyrosine phosphorylation of Stat3 protein, positive regulation of tyrosine phosphorylation of Stat3 protein, protein autophosphorylation, protein phosphorylation, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, STAT protein import into nucleus, phosphatidylinositol 3-kinase binding, positive regulation of phosphatidylinositol 3-kinase cascade, positive regulation of sequence-specific DNA binding transcription factor activity |
| InterPro Term |
SH2, Se/Thr_prot_kinase-like_dom, Kinase-like_dom, Ser/Thr_prot_kinase_dom, Tyr_prot_kinase_AS, Prot_kinase_cat_dom, Band_41_domain, Tyr_Pkinase_cat_dom, Protein_kinase_ATP_BS, FERM_domain, Ser-Thr/Tyr-Pkinase, Tyr_kinase_non-rcpt_Jak/Tyk2, Tyr_kinase_non-rcpt_Jak2 |
| Gene Ontology ID |
GO:0008285, GO:0008284, GO:0016020, GO:0016568, GO:0007186, GO:0007165, GO:0016363, GO:0007243, GO:0007259, GO:0007262, GO:0007204, GO:0009755, GO:0005901, GO:0042393, GO:0016772, GO:0004713, GO:0004715, GO:0005624, GO:0005524, GO:0005515, GO:0012505, GO:0005737, GO:0005634, GO:0005856, GO:0005829, GO:0006979, GO:0004672, GO:0004674, GO:0005102, GO:0032516, GO:0043065, GO:0019901, GO:0006468, GO:0000166, GO:0000186, GO:0046777, GO:0043392, GO:0042169, GO:0019221, GO:0043560, GO:0043548, GO:0045822, GO:0046677, GO:0045429, GO:0033130, GO:0020037, GO:0048008, GO:0060397, GO:0060399, GO:0060396, GO:0008631, GO:0007167, GO:0022408, GO:0051428, GO:0031959, GO:0051091, GO:0042508, GO:0042503, GO:0042523, GO:0042517, GO:0014068, GO:0042977, GO:0005131, GO:0005143, GO:0050731, GO:0050729, GO:0050727, GO:0032731, GO:0031103, GO:0050867, GO:0043388, GO:0070671, GO:0045597, GO:0043526, GO:0035401, GO:0035409, GO:0030335, GO:0030218, GO:0033194, GO:0033160, GO:0033209, GO:0032024, GO:0034612, GO:0010811, GO:0060333, GO:0035722 |
| Ensembl Gene ID |
ENSRNOG00000015547 |
| Ensembl Protein ID |
ENSRNOP00000021218 |
| RGD ID |
2939 |
| RefSeq ID |
NP_113702, NM_031514 |
| UniGene ID |
Rn.18909 |
| Entrez Gene ID |
24514 |
| EMBL-Bank ID |
U13396 |
| UniProt Accession |
Q62689, F1M9X6 |
| Ensembl Family |
ENSFM00250000000777 |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 JANUS KINASE JAK |
| RGD Symbol |
Jak2 |
| Ensembl Transcript ID |
ENSRNOT00000021217 |
| Description |
Tyrosine-protein kinase JAK2 [Source:UniProtKB/Swiss-Prot;Acc:Q62689] |
| Design Element |
6605198, 5739756, ENSRNOT00000021217, 5704886, U13396_g_at, 6158145, 6392550, 6463579, 6729078, 6236523, 6214771, U13396_at, 6472971, 6353515, 6266362, 6737860, 6689868, 6531237, rc_AI145235_at, 6386101, 6681926, 6104975, 5664257, 6592389, AJ000557cds_s_at, 6131574, 6280783, 5692305, 6716481, 1368856_at, 5671561, 6564338, 6393539, 6658532, 5719932, 6609269, 6532144, 5977605, 5829573 |
| Search EB-eye |
ENSRNOG00000015547
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