Jak2
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Mus musculus |
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Jak2 is differentially expressed in 251 experiments: 108 organism parts: liver, spleen, ... (106 more);, 14 disease states: normal, 3-NP-induced neurodegeneration model of Huntington's disease, ... (12 more);, 71 cell types 19 cell lines 33 compound treatments and 43 other conditions. |
| Synonyms |
'C81284' |
| Orthologs |
F1NQU4_CHICK
(Gallus gallus)
Jak2
(Rattus norvegicus)
E1BCP6_BOVIN
(Bos taurus)
JAK2
(Homo sapiens)
Q4H3A3_CIOIN
(Ciona intestinalis)
PR2
(Drosophila melanogaster)
jak2
(Xenopus laevis)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR019749, IPR000980, IPR020635, IPR016251, IPR020693 |
| Gene Ontology Term |
cytosol, response to antibiotic, response to oxidative stress, positive regulation of nitric oxide biosynthetic process, elevation of cytosolic calcium ion concentration, protein binding, SH2 domain binding, cytokine-mediated signaling pathway, cytoplasm, histone binding, positive regulation of cell proliferation, membrane, hormone-mediated signaling pathway, G-protein coupled receptor protein signaling pathway, protein tyrosine kinase activity, receptor binding, insulin receptor substrate binding, negative regulation of heart contraction, nuclear matrix, heme binding, membrane fraction, positive regulation of apoptosis, positive regulation of phosphoprotein phosphatase activity, activation of MAPKK activity, ATP binding, protein kinase binding, nucleus, protein serine/threonine kinase activity, acetylcholine receptor binding, JAK-STAT cascade, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, intracellular protein kinase cascade, positive regulation of cell-substrate adhesion, tumor necrosis factor-mediated signaling pathway, mineralocorticoid receptor signaling pathway, response to hydroperoxide, neuroprotection, negative regulation of cell-cell adhesion, response to tumor necrosis factor, positive regulation of protein import into nucleus, translocation, histone kinase activity (H3-Y41 specific), axon regeneration, platelet-derived growth factor receptor signaling pathway, positive regulation of DNA binding, growth hormone receptor binding, positive regulation of cell migration, histone H3-Y41 phosphorylation, positive regulation of insulin secretion, tyrosine phosphorylation of Stat1 protein, positive regulation of cell differentiation, growth hormone receptor signaling pathway, positive regulation of inflammatory response, induction of apoptosis by oxidative stress, regulation of inflammatory response, response to interleukin-12, positive regulation of interleukin-1 beta production, positive regulation of cell activation, peptide hormone receptor binding, tyrosine phosphorylation of Stat3 protein, protein autophosphorylation, protein phosphorylation, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, phosphatidylinositol 3-kinase binding, positive regulation of sequence-specific DNA binding transcription factor activity |
| InterPro Term |
SH2, Band_41_domain, Tyr_kinase_non-rcpt_Jak/Tyk2, Tyr_kinase_non-rcpt_Jak2, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Gene Ontology ID |
GO:0008284, GO:0016020, GO:0007186, GO:0016363, GO:0007243, GO:0007259, GO:0007204, GO:0009755, GO:0042393, GO:0004713, GO:0004715, GO:0005624, GO:0005524, GO:0005515, GO:0005737, GO:0005634, GO:0005829, GO:0006979, GO:0004672, GO:0004674, GO:0005102, GO:0032516, GO:0043065, GO:0019901, GO:0006468, GO:0000186, GO:0046777, GO:0042169, GO:0019221, GO:0043560, GO:0043548, GO:0045822, GO:0046677, GO:0045429, GO:0033130, GO:0020037, GO:0048008, GO:0060396, GO:0008631, GO:0022408, GO:0051428, GO:0031959, GO:0051091, GO:0042508, GO:0042503, GO:0005131, GO:0050729, GO:0050727, GO:0032731, GO:0031103, GO:0050867, GO:0043388, GO:0070671, GO:0045597, GO:0043526, GO:0035401, GO:0035409, GO:0030335, GO:0033194, GO:0033160, GO:0033209, GO:0032024, GO:0034612, GO:0010811, GO:0060333, GO:0035722 |
| Ensembl Family |
ENSFM00250000000777 |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 JANUS KINASE JAK |
| MGI Symbol |
Jak2 |
| MGI ID |
MGI:96629 |
| Ensembl Gene ID |
ENSMUSG00000024789 |
| RefSeq ID |
NM_001048177, NM_008413 |
| EMBL-Bank ID |
AY157991 |
| Entrez Gene ID |
16452 |
| MGI Description |
Janus kinase 2 |
| Ensembl Transcript ID |
ENSMUST00000025705, ENSMUST00000065796 |
| Design Element |
10462363, 4957482, L16956_g_at, L16956_at, 5553169, 5616931, 5461833, gnf1m01332_a_at, 5067672, 4602344, Msa.33484.0_s_at, 5092397, 4458597, 1421066_at, 4320675, 4720017, 5286663, 5193242, 5244501, 5465746, 4601783, 4975530, 5587547, c81467_rc_g_at, 101457_at, 4716127, 5173838, 1421065_at, ENSMUST00000025705, 5434548, 4547734, 5543451, 5504682, 4368800, 5102979, 5555318, 5268017, 4753707, ENSMUST00000065796, 4935501, 5349427, 4615571 |
| Search EB-eye |
ENSMUSG00000024789
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