TNF
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Homo sapiens |
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TNF is differentially expressed in 214 experiments: 62 organism parts: lung, kidney, ... (60 more);, 96 disease states: normal, Burkitt's lymphoma, ... (94 more);, 81 cell types 199 cell lines 36 compound treatments and 59 other conditions. |
| Synonyms |
TNF-alpha, TNFA, DIF, TNFSF2 |
| Orthologs |
tnfb
(Danio rerio)
tnfa
(Danio rerio)
TNFA_BOVIN
(Bos taurus)
Tnf
(Mus musculus)
Tnf
(Rattus norvegicus)
tnf
(Xenopus laevis)
TNFA_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0009897, GO:0009887, GO:0008285, GO:0009986, GO:0016020, GO:0016021, GO:0007165, GO:0009612, GO:0009651, GO:0007254, GO:0007275, GO:0030730, GO:0042493, GO:0048566, GO:0051092, GO:0000060, GO:0003009, GO:0042802, GO:0005622, GO:0005615, GO:0005515, GO:0005576, GO:0042742, GO:0006916, GO:0006915, GO:0006919, GO:0006917, GO:0006959, GO:0006955, GO:0006952, GO:0005886, GO:0005887, GO:0005125, GO:0055037, GO:0019722, GO:0005164, GO:0046330, GO:0031334, GO:0043066, GO:0001932, GO:0001934, GO:0050708, GO:0043122, GO:0050830, GO:0000187, GO:0000185, GO:0000122, GO:0042127, GO:0045944, GO:0051533, GO:0045892, GO:0045893, GO:0001666, GO:0043406, GO:0006006, GO:0030198, GO:0045121, GO:0045429, GO:0045071, GO:0002020, GO:0060693, GO:0060664, GO:0060555, GO:0060557, GO:0060559, GO:0034116, GO:0008625, GO:0008624, GO:0009615, GO:0051384, GO:0002876, GO:0042346, GO:0051222, GO:0002740, GO:0048661, GO:0051023, GO:0051044, GO:0051091, GO:0002439, GO:0061048, GO:0006927, GO:0006954, GO:0002037, GO:0046325, GO:0050796, GO:0050715, GO:0043123, GO:0032715, GO:0032729, GO:0032722, GO:0050806, GO:0032755, GO:0051798, GO:0031622, GO:0032800, GO:0001775, GO:0014823, GO:0045670, GO:0045672, GO:0051897, GO:0001891, GO:0045599, GO:0043243, GO:0001819, GO:0045994, GO:0043525, GO:0044212, GO:0045840, GO:0044130, GO:0070265, GO:0002925, GO:0045123, GO:0030316, GO:0070374, GO:0050901, GO:0050900, GO:0033138, GO:0050995, GO:0033209, GO:0045080, GO:0010888, GO:0010940, GO:0071316, GO:0071230, GO:0071803 |
| Gene Ontology Term |
humoral immune response, plasma membrane, glucose metabolic process, positive regulation of nitric oxide biosynthetic process, sequestering of triglyceride, negative regulation of transcription, DNA-dependent, protein binding, apoptosis, response to salt stress, regulation of cell proliferation, intracellular, negative regulation of cell proliferation, extracellular space, embryonic digestive tract development, membrane, tumor necrosis factor receptor binding, protein import into nucleus, translocation, negative regulation of apoptosis, activation of caspase activity, extracellular region, positive regulation of MAP kinase activity, membrane raft, anti-apoptosis, response to hypoxia, cytokine activity, skeletal muscle contraction, external side of plasma membrane, positive regulation of JNK cascade, activation of MAPK activity, positive regulation of NFAT protein import into nucleus, recycling endosome, defense response to Gram-positive bacterium, identical protein binding, induction of apoptosis, defense response, positive regulation of transcription from RNA polymerase II promoter, multicellular organismal development, positive regulation of protein complex assembly, negative regulation of viral genome replication, integral to plasma membrane, defense response to bacterium, regulation of protein secretion, immune response, response to drug, JNK cascade, integral to membrane, positive regulation of NF-kappaB transcription factor activity, regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of transcription from RNA polymerase II promoter, calcium-mediated signaling, cell surface, extracellular matrix organization, signal transduction, positive regulation of transcription, DNA-dependent, organ morphogenesis, activation of MAPKKK activity, response to mechanical stimulus, protease binding, positive regulation of heterotypic cell-cell adhesion, positive regulation of calcidiol 1-monooxygenase activity, positive regulation of I-kappaB kinase/NF-kappaB cascade, response to activity, negative regulation of glucose import, positive regulation of protein complex disassembly, positive regulation of peptidyl-serine phosphorylation, tumor necrosis factor-mediated signaling pathway, positive regulation of NF-kappaB import into nucleus, positive regulation of hair follicle development, positive regulation of translational initiation by iron, leukocyte migration, positive regulation of chronic inflammatory response to antigenic stimulus, positive regulation of ERK1 and ERK2 cascade, regulation of immunoglobulin secretion, necrotic cell death, induction of apoptosis via death domain receptors, positive regulation of cytokine production, positive regulation of chemokine biosynthetic process, positive regulation of cytokine secretion, positive regulation of humoral immune response mediated by circulating immunoglobulin, negative regulation of lipid catabolic process, positive regulation of synaptic transmission, chronic inflammatory response to antigenic stimulus, regulation of branching involved in salivary gland morphogenesis, positive regulation of interferon-gamma production, response to virus, negative regulation of branching involved in lung morphogenesis, positive regulation of necrotic cell death, positive regulation of protein transport, positive regulation of interleukin-6 production, negative regulation of lipid storage, positive regulation of vitamin D biosynthetic process, negative regulation of interleukin-6 production, negative regulation of fat cell differentiation, negative regulation of cytokine secretion involved in immune response, regulation of osteoclast differentiation, induction of necroptosis by extracellular signals, negative regulation of growth of symbiont in host, cellular extravasation, positive regulation of membrane protein ectodomain proteolysis, epithelial cell proliferation involved in salivary gland morphogenesis, inflammatory response, induction of apoptosis by extracellular signals, positive regulation of osteoclast differentiation, positive regulation of neuron apoptosis, leukocyte tethering or rolling, transformed cell apoptosis, positive regulation of smooth muscle cell proliferation, regulation of insulin secretion, negative regulation of L-glutamate transport, positive regulation of chemokine production, positive regulation of protein kinase B signaling cascade, cell activation, phagocytic cup, positive regulation of mitosis, response to glucocorticoid stimulus, osteoclast differentiation, receptor biosynthetic process, regulation of protein phosphorylation, positive regulation of protein phosphorylation, positive regulation of podosome assembly, positive regulation of fever generation, cellular response to amino acid stimulus, transcription regulatory region DNA binding, positive regulation of sequence-specific DNA binding transcription factor activity, cellular response to nicotine |
| InterPro ID |
IPR006052, IPR002959, IPR006053 |
| InterPro Term |
TNF_family, TNF_a/b/c, TNF_alpha |
| Ensembl Family |
ENSFM00500000270059 |
| EMBL-Bank ID |
FJ795028, BX927320, AL662801, AL662847, X01394, AB088112, AL929587, M26331, BC028148, CR753892, M10988, BA000025, AB202113, AF098751, AY066019, CR942185, CH471081, AB103618, AK314960, AF043342, Z15026, X02910, BX248519, CR759886, M16441, Y14768, AY214167, AF129756, AB451492, HQ201306 |
| Ensembl Protein ID |
ENSP00000398698 |
| HGNC Symbol |
TNF |
| Gene-Disease Assocation |
PSORIATIC ARTHRITIS, SUSCEPTIBILITY TO, PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL, MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1, MALARIA, SUSCEPTIBILITY TO, HEPATITIS B VIRUS, SUSCEPTIBILITY TO, ASTHMA, SUSCEPTIBILITY TO |
| UniProt Accession |
B5BUQ6, B0V0H5, C1K3N5, P01375, Q5STB3 |
| Description |
tumor necrosis factor [Source:HGNC Symbol;Acc:11892] |
| Entrez Gene ID |
7124 |
| UniGene ID |
Hs.241570 |
| RefSeq ID |
NP_000585, NM_000594 |
| Ensembl Gene ID |
ENSG00000232810 |
| Ensembl Family Description |
TUMOR NECROSIS FACTOR PRECURSOR CACHECTIN TNF ALPHA TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 2 TNF A [CONTAINS TUMOR NECROSIS FACTOR MEMBRANE FORM; TUMOR NECROSIS FACTOR SOLUBLE FORM] |
| Ensembl Transcript ID |
ENST00000449264 |
| Design Element |
X02910_at, ENST00000449264, 207113_s_at, g10835154_3p_a_at, 259_s_at, 1852_at |
| Search EB-eye |
ENSG00000232810
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