TOP1
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Homo sapiens |
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TOP1 is differentially expressed in 323 experiments: 131 organism parts: liver, lung, ... (129 more);, 219 disease states: normal, control, ... (217 more);, 93 cell types 384 cell lines 50 compound treatments and 73 other conditions. |
| Orthologs |
TOP1
(Saccharomyces cerevisiae)
F1NPT1_CHICK
(Gallus gallus)
top1l
(Danio rerio)
ENSCING00000016260
(Ciona intestinalis)
F1MN93_BOVIN
(Bos taurus)
F1M1S6_RAT
(Rattus norvegicus)
Top1
(Mus musculus)
Top1
(Rattus norvegicus)
top1
(Danio rerio)
F6PHJ8_CIOIN
(Ciona intestinalis)
Top1
(Drosophila melanogaster)
ENSXETG00000013237
(Xenopus laevis)
Q9XT65_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0003682, GO:0003677, GO:0003917, GO:0003918, GO:0016310, GO:0042493, GO:0005524, GO:0005515, GO:0012501, GO:0005730, GO:0005737, GO:0005694, GO:0005634, GO:0005654, GO:0040016, GO:0000166, GO:0000228, GO:0006265, GO:0006260, GO:0031490, GO:0044419, GO:0043204 |
| InterPro ID |
IPR001631, IPR008336, IPR013499, IPR013500 |
| Gene Ontology Term |
phosphorylation, DNA binding, protein binding, cytoplasm, embryonic cleavage, nuclear chromosome, programmed cell death, ATP binding, nucleus, chromatin DNA binding, nucleotide binding, response to drug, DNA topoisomerase (ATP-hydrolyzing) activity, chromatin binding, chromosome, nucleoplasm, DNA topological change, DNA topoisomerase type I activity, DNA replication, nucleolus, perikaryon, interspecies interaction between organisms |
| InterPro Term |
TopoI_cat_euk, TopoI_C_euk, TopoI_C, TopoI_DNA-bd_euk |
| Ensembl Family |
ENSFM00250000001314 |
| Ensembl Family Description |
DNA TOPOISOMERASE 1 EC_5.99.1.2 DNA TOPOISOMERASE I |
| Description |
topoisomerase (DNA) I [Source:HGNC Symbol;Acc:11986] |
| EMBL-Bank ID |
M60700, M60701, M60703, M60702, M60705, M60704, M60706, M60692, M60693, M60690, M60691, M60696, M60697, M60694, M60695, M60689, M60688, M60699, M60698, J03250, X16479, X52601, AL035652, AK292943, AL022394, CH471077, U07804, U07806, BC000943, M27913 |
| RefSeq ID |
NM_003286, NP_003277 |
| UniProt Accession |
P11387, Q9BVT2 |
| Entrez Gene ID |
7150 |
| UniGene ID |
Hs.472737 |
| Ensembl Gene ID |
ENSG00000198900 |
| Ensembl Protein ID |
ENSP00000354522 |
| HGNC Symbol |
TOP1 |
| Ensembl Transcript ID |
ENST00000361337 |
| Design Element |
U07806_s_at, ENST00000361337, 1030_s_at, Hs.317.0.S1_3p_a_at, 31680_at, 1710_s_at, g339805_3p_a_at, 208901_s_at, U07804_s_at, 208900_s_at |
| Search EB-eye |
ENSG00000198900
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