MTOR
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Homo sapiens |
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MTOR is differentially expressed in 166 experiments: 76 organism parts: testis, kidney, ... (74 more);, 130 disease states: normal, acute promyelocytic leukemia, ... (128 more);, 45 cell types 222 cell lines 13 compound treatments and 57 other conditions. |
| Synonyms |
RAPT1, FLJ44809, FRAP1, FRAP2, FRAP, RAFT1 |
| Orthologs |
MTOR
(Bos taurus)
mtor
(Danio rerio)
Mtor
(Rattus norvegicus)
TOR1
(Saccharomyces cerevisiae)
ENSCING00000001460
(Ciona intestinalis)
Mtor
(Mus musculus)
MTOR
(Gallus gallus)
Tor
(Drosophila melanogaster)
MTOR
(Canis familiaris)
XB-GENE-994583
(Xenopus laevis)
(Compare orthologs)
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| Gene Ontology Term |
negative regulation of macroautophagy, endomembrane system, cytosol, phosphorylation, endoplasmic reticulum, protein binding, positive regulation of translation, phosphotransferase activity, alcohol group as acceptor, cytoplasm, protein catabolic process, peptidyl-serine phosphorylation, membrane, lysosome, Golgi membrane, Golgi apparatus, regulation of protein kinase activity, insulin receptor signaling pathway, protein domain specific binding, fibroblast growth factor receptor signaling pathway, mitochondrial outer membrane, cell growth, soluble fraction, positive regulation of actin filament polymerization, response to nutrient, ATP binding, growth, transferase activity, transferring phosphorus-containing groups, regulation of response to food, nucleus, dendrite, germ cell development, negative regulation of autophagy, nucleotide binding, kinase activity, protein serine/threonine kinase activity, phosphoprotein binding, binding, regulation of actin cytoskeleton organization, cell projection organization, peptidyl-threonine phosphorylation, endoplasmic reticulum membrane, ribosome binding, signal transduction, negative regulation of cell size, mitochondrion, neuronal cell body, TOR signaling cascade, positive regulation of lamellipodium assembly, ruffle organization, positive regulation of peptidyl-tyrosine phosphorylation, cellular response to hypoxia, TORC2 complex, TORC1 complex, cellular response to nutrient levels, regulation of Rac GTPase activity, positive regulation of stress fiber assembly, response to amino acid stimulus, PML body, response to insulin stimulus, regulation of carbohydrate metabolic process, regulation of glycogen biosynthetic process, positive regulation of transcription from RNA polymerase III promoter, nerve growth factor receptor signaling pathway, positive regulation of endothelial cell proliferation, T cell costimulation, positive regulation of protein kinase B signaling cascade, regulation of carbohydrate utilization, regulation of fatty acid beta-oxidation, negative regulation of NFAT protein import into nucleus, protein autophosphorylation, protein phosphorylation, positive regulation of protein phosphorylation, phosphatidylinositol-mediated signaling, phosphatidylinositol 3-kinase complex, RNA polymerase III type 2 promoter DNA binding, TFIIIC-class transcription factor binding, RNA polymerase III type 1 promoter DNA binding, RNA polymerase III type 3 promoter DNA binding, mTOR-FKBP12-rapamycin complex |
| Gene Ontology ID |
GO:0048015, GO:0008286, GO:0016049, GO:0016020, GO:0010507, GO:0007165, GO:0007281, GO:0016310, GO:0016301, GO:0016242, GO:0008543, GO:0005942, GO:0007584, GO:0051219, GO:0030425, GO:0016773, GO:0016772, GO:0005488, GO:0005625, GO:0005524, GO:0005515, GO:0012505, GO:0005737, GO:0005739, GO:0005741, GO:0005634, GO:0005829, GO:0005789, GO:0005783, GO:0005794, GO:0005764, GO:0030838, GO:0004674, GO:0040007, GO:0019904, GO:0001934, GO:0006468, GO:0043022, GO:0043025, GO:0000166, GO:0045727, GO:0000139, GO:0018105, GO:0018107, GO:0045792, GO:0046777, GO:0032956, GO:0045859, GO:0030163, GO:0030030, GO:0032095, GO:0048011, GO:0010592, GO:0016605, GO:0005979, GO:0031998, GO:0031929, GO:0031931, GO:0031932, GO:0043610, GO:0031295, GO:0001938, GO:0050731, GO:0031669, GO:0032868, GO:0051897, GO:0043200, GO:0045945, GO:0051534, GO:0051496, GO:0006109, GO:0031529, GO:0071456, GO:0032314, GO:0001156, GO:0001030, GO:0001031, GO:0001032, GO:0070438 |
| InterPro ID |
IPR000403, IPR014009, IPR009076, IPR003152, IPR003151, IPR024585 |
| InterPro Term |
PIK_FAT, PIK-rel_kinase_FAT, FKBP_rapamycin-assoc_FKBP12-bd, FATC, PI3/4_kinase_cat, DUF3385_TOR |
| Ensembl Family |
ENSFM00260000050608 |
| Ensembl Family Description |
SERINE/THREONINE KINASE RAPAMYCIN TARGET OF RAPAMYCIN |
| EMBL-Bank ID |
AL391561, AJ300188, L35478, BC117166, AB209995, AL359082, L34075, AL109811, U88966, AL049653 |
| Ensembl Protein ID |
ENSP00000398745, ENSP00000366034, ENSP00000354558, ENSP00000440730 |
| HGNC Symbol |
MTOR |
| UniProt Accession |
Q96QW8, B1AKP8, B1AKQ2, P42345, F5GYA6 |
| Entrez Gene ID |
2475 |
| UniGene ID |
Hs.659634, Hs.338207 |
| Description |
mechanistic target of rapamycin (serine/threonine kinase) [Source:HGNC Symbol;Acc:3942] |
| Ensembl Gene ID |
ENSG00000198793 |
| RefSeq ID |
NP_004949, NM_004958 |
| Ensembl Transcript ID |
ENST00000495435, ENST00000476768, ENST00000473471, ENST00000539766, ENST00000490931, ENST00000376838, ENST00000455339, ENST00000361445 |
| Design Element |
ENST00000539766, ENST00000361445, 267_at, ENST00000490931, 45997_at, ENST00000455339, ENST00000495435, ENST00000376838, 40139_at, g3282238_3p_at, gnf1h09537_s_at, ENST00000476768, L34075_at, 202288_at, ENST00000473471 |
| Search EB-eye |
ENSG00000198793
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