WT1
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Homo sapiens |
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WT1 is differentially expressed in 239 experiments: 151 organism parts: kidney, ovary, ... (149 more);, 156 disease states: normal, Huntington's disease, ... (154 more);, 79 cell types 431 cell lines 30 compound treatments and 71 other conditions. |
| Synonyms |
WIT-2, AWT1, WAGR, GUD |
| Orthologs |
FZF1
(Saccharomyces cerevisiae)
wt1a
(Danio rerio)
wt1b
(Danio rerio)
Wt1
(Mus musculus)
WT1
(Gallus gallus)
Wt1
(Rattus norvegicus)
Cf2
(Drosophila melanogaster)
wt1
(Xenopus laevis)
WT1
(Canis familiaris)
WT1
(Bos taurus)
(Compare orthologs)
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| Gene Ontology ID |
GO:0009888, GO:0003676, GO:0003690, GO:0008285, GO:0008270, GO:0008380, GO:0003723, GO:0003700, GO:0016607, GO:0007281, GO:0008406, GO:0008584, GO:0007507, GO:0007530, GO:0030539, GO:0005622, GO:0005515, GO:0006917, GO:0005730, GO:0005737, GO:0005634, GO:0005654, GO:0043066, GO:0000122, GO:0046872, GO:0006355, GO:0006357, GO:0006351, GO:0045944, GO:0043565, GO:0045892, GO:0045893, GO:0030308, GO:0017148, GO:0060421, GO:0060539, GO:0072302, GO:0060231, GO:0072112, GO:0072166, GO:0072207, GO:0072284, GO:0061032, GO:0030855, GO:0043010, GO:0070742, GO:0032836, GO:0032835, GO:0001822, GO:0001823, GO:0001570, GO:0044212, GO:0001658, GO:0001656, GO:0001657, GO:0071371, GO:0071320, GO:0035502, GO:0030325, GO:0072075, GO:2000195, GO:0003156, GO:2000020, GO:0001077, GO:0060923, GO:0035802, GO:0007356 |
| Gene Ontology Term |
negative regulation of cell growth, RNA splicing, negative regulation of transcription, DNA-dependent, protein binding, nuclear speck, regulation of transcription, DNA-dependent, cytoplasm, double-stranded DNA binding, intracellular, negative regulation of cell proliferation, transcription, DNA-dependent, sex determination, negative regulation of apoptosis, male genitalia development, metal ion binding, nucleic acid binding, male gonad development, gonad development, sequence-specific DNA binding, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, tissue development, nucleus, heart development, germ cell development, nucleoplasm, negative regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, negative regulation of translation, positive regulation of transcription, DNA-dependent, RNA binding, nucleolus, zinc ion binding, posterior mesonephric tubule development, positive regulation of heart growth, cellular response to cAMP, glomerular basement membrane development, cellular response to gonadotropin stimulus, kidney development, branching involved in ureteric bud morphogenesis, visceral serous pericardium development, mesonephros development, diaphragm development, adrenal gland development, metanephric S-shaped body morphogenesis, C2H2 zinc finger domain binding, metanephric epithelium development, glomerular visceral epithelial cell differentiation, vasculogenesis, metanephros development, glomerulus development, camera-type eye development, negative regulation of metanephric glomerular mesangial cell proliferation, mesenchymal to epithelial transition, ureteric bud development, epithelial cell differentiation, metanephric ureteric bud development, sequence-specific DNA binding transcription factor activity, negative regulation of female gonad development, metanephric mesenchyme development, transcription regulatory region DNA binding, regulation of organ formation, positive regulation of male gonad development, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, adrenal cortex formation, cardiac muscle cell fate commitment, thorax and anterior abdomen determination |
| InterPro Term |
Znf_C2H2-like, Znf_C2H2, Wilms_tumour, Wilms_tumour_N |
| InterPro ID |
IPR017987, IPR007087, IPR015880, IPR000976 |
| Ensembl Family |
ENSFM00250000002802 |
| Ensembl Family Description |
WILMS TUMOR HOMOLOG |
| EMBL-Bank ID |
AK291736, S60755, D13624, AK093168, M30393, X51630, BC032861, S75264, X72314, CH471064, M80217, M80218, M80219, M80220, M80221, M80228, M80229, M80231, M80232, AY245105, X61631, X61634, X61635, X61632, X61633, X61638, X61636, X61637, BC046461, S61522, S61524, S61515, EF012821, EF012820, AL049692 |
| Ensembl Protein ID |
ENSP00000331327, ENSP00000413452, ENSP00000415516, ENSP00000368368, ENSP00000368370, ENSP00000436292, ENSP00000435624, ENSP00000435351, ENSP00000435307 |
| HGNC Symbol |
WT1 |
| Ensembl Gene ID |
ENSG00000184937 |
| UniGene ID |
Hs.606557, Hs.591980 |
| RefSeq ID |
NP_077742, NP_077744, NP_000369, NM_000378, NM_024426, NM_024424, NP_001185481, NP_001185480, NM_001198552, NM_001198551 |
| Gene-Disease Assocation |
WILMS TUMOR, ANIRIDIA, GENITOURINARY ANOMALIES, AND MENTAL RETARDATION, MEACHAM SYNDROME, FRASIER SYNDROME, DENYS-DRASH SYNDROME; DDS, WILMS TUMOR 1; WT1, NEPHROTIC SYNDROME, TYPE 4; NPHS4, MESOTHELIOMA, MALIGNANT |
| UniProt Accession |
A8MN20, Q6PI38, Q6LBI3, B3KSA5, P19544, A0FJ57, A0FJ58, E9PPW3, E9PKS2, E9PMK7, E9PP08 |
| Description |
Wilms tumor 1 [Source:HGNC Symbol;Acc:12796] |
| Entrez Gene ID |
7490 |
| Ensembl Transcript ID |
ENST00000530998, ENST00000526685, ENST00000332351, ENST00000452863, ENST00000527775, ENST00000527882, ENST00000448076, ENST00000379079, ENST00000379077 |
| Design Element |
ENST00000527775, ENST00000332351, ENST00000530998, ENST00000379079, ENST00000379077, 1500_at, g13386509_3p_a_at, ENST00000448076, Hs.1145.2.S1_3p_a_at, X51630_at, ENST00000526685, ENST00000527882, 216953_s_at, 206067_s_at, 1684_s_at, ENST00000452863 |
| Search EB-eye |
ENSG00000184937
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