CHEK2
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Homo sapiens |
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CHEK2 is differentially expressed in 233 experiments: 99 organism parts: bone marrow, prostate, ... (97 more);, 165 disease states: normal, glioblastoma, ... (163 more);, 66 cell types 295 cell lines 27 compound treatments and 62 other conditions. |
| Synonyms |
PP1425, bA444G7, CDS1, CHK2, RAD53, HuCds1 |
| Orthologs |
Chek2
(Mus musculus)
ENSCING00000004987
(Ciona intestinalis)
chek2
(Danio rerio)
Chek2
(Rattus norvegicus)
Q58DJ9_BOVIN
(Bos taurus)
A1EAT1_CHICK
(Gallus gallus)
DUN1
(Saccharomyces cerevisiae)
lok
(Drosophila melanogaster)
chek2
(Xenopus laevis)
CHEK2
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR000253, IPR001245, IPR017442, IPR000719, IPR020635 |
| Gene Ontology Term |
chromosome, telomeric region, DNA damage checkpoint, protein binding, apoptosis, DNA damage response, signal transduction resulting in induction of apoptosis, metal ion binding, protein tyrosine kinase activity, ATP binding, cell cycle, transferase activity, transferring phosphorus-containing groups, nucleus, nucleotide binding, kinase activity, protein serine/threonine kinase activity, nucleoplasm, cell cycle checkpoint, response to DNA damage stimulus, response to gamma radiation, protein kinase activity, PML body, protein phosphorylation, replicative senescence, signal transduction in response to DNA damage |
| Gene Ontology ID |
GO:0010332, GO:0007049, GO:0008630, GO:0016301, GO:0016772, GO:0000077, GO:0000075, GO:0004713, GO:0005524, GO:0005515, GO:0006915, GO:0005634, GO:0005654, GO:0006974, GO:0004672, GO:0004674, GO:0000781, GO:0006468, GO:0000166, GO:0046872, GO:0016605, GO:0042770, GO:0090399 |
| InterPro Term |
Prot_kinase_cat_dom, FHA_dom, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00450000242177 |
| Ensembl Family Description |
KINASE EC_2.7.11.1 |
| EMBL-Bank ID |
AY551295, AY551296, AY551297, AY551299, AY551298, AY551301, AY551302, AY551300, AY551305, AY551304, AY551303, AL117330, AK290754, AF086904, AJ131197, AF217975, BC004207, CH471095, AF174135, AL121825, AF096279, CR456418, AY800241, AB040105 |
| RefSeq ID |
NM_001005735, NM_145862, NP_001005735, NP_009125, NP_665861, NM_007194 |
| UniGene ID |
Hs.505297, Hs.291363 |
| Ensembl Protein ID |
ENSP00000372021, ENSP00000372023, ENSP00000372006, ENSP00000372007, ENSP00000372003, ENSP00000408065, ENSP00000403659, ENSP00000385747, ENSP00000416721, ENSP00000396903, ENSP00000394430, ENSP00000329012, ENSP00000381099, ENSP00000387451, ENSP00000390244, ENSP00000404567, ENSP00000397478, ENSP00000329178, ENSP00000384835, ENSP00000384919, ENSP00000402225, ENSP00000412901, ENSP00000404400, ENSP00000386087, ENSP00000442458 |
| UniProt Accession |
B7ZBH9, B7ZBI0, B7ZBF2, B7ZBF6, B7ZBF7, B7ZBF8, O96017, Q9HBS5, C9JFD8, C9JFD7, E7EPP1, F8WCV2 |
| Ensembl Gene ID |
ENSG00000183765 |
| Description |
CHK2 checkpoint homolog (S. pombe) [Source:HGNC Symbol;Acc:16627] |
| Gene-Disease Assocation |
OSTEOGENIC SARCOMA, PROSTATE CANCER, BREAST CANCER, CHECKPOINT KINASE 2, S. POMBE, HOMOLOG OF; CHEK2, LI-FRAUMENI SYNDROME 2; LFS2 |
| HGNC Symbol |
CHEK2 |
| Entrez Gene ID |
11200 |
| Ensembl Transcript ID |
ENST00000403642, ENST00000433728, ENST00000417588, ENST00000434810, ENST00000416671, ENST00000404276, ENST00000447421, ENST00000454252, ENST00000544772, ENST00000328354, ENST00000382578, ENST00000382580, ENST00000382563, ENST00000382565, ENST00000382566, ENST00000425190, ENST00000402731, ENST00000448511, ENST00000348295, ENST00000398017, ENST00000472807, ENST00000433028, ENST00000456369, ENST00000491919, ENST00000405598, ENST00000439200, ENST00000439346, ENST00000464581 |
| Design Element |
ENST00000405598, ENST00000382563, ENST00000382580, ENST00000464581, ENST00000382565, ENST00000454252, ENST00000456369, ENST00000491919, ENST00000382566, ENST00000448511, ENST00000398017, ENST00000433728, ENST00000472807, ENST00000439200, ENST00000402731, ENST00000425190, ENST00000404276, ENST00000416671, g13278893_3p_a_at, ENST00000433028, ENST00000417588, ENST00000434810, ENST00000348295, ENST00000447421, ENST00000382578, ENST00000328354, 37887_at, ENST00000439346, ENST00000403642, ENST00000544772, 210416_s_at |
| Search EB-eye |
ENSG00000183765
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