NKX2-5
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Homo sapiens |
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NKX2-5 is differentially expressed in 171 experiments: 68 organism parts: heart, spleen, ... (66 more);, 122 disease states: normal, acute lymphoblastic leukemia, ... (120 more);, 56 cell types 264 cell lines 24 compound treatments and 60 other conditions. |
| Synonyms |
CSX1, NKX2E, CSX, NKX2.5, NKX4-1 |
| Orthologs |
F1NC42_CHICK
(Gallus gallus)
Nkx2-5
(Mus musculus)
nkx2.5
(Danio rerio)
Q29RN9_BOVIN
(Bos taurus)
F6VT63_CIOIN
(Ciona intestinalis)
Nkx2-5
(Rattus norvegicus)
nkx2-5
(Xenopus laevis)
NP_001010959.1
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008134, GO:0003682, GO:0003677, GO:0010628, GO:0008284, GO:0003700, GO:0003705, GO:0060048, GO:0060070, GO:0060261, GO:0007275, GO:0007507, GO:0048738, GO:0030509, GO:0003007, GO:0042803, GO:0005515, GO:0005737, GO:0005634, GO:0005667, GO:0055007, GO:0043066, GO:0000122, GO:0006355, GO:0006357, GO:0006351, GO:0046982, GO:0045944, GO:0043565, GO:0045823, GO:0045892, GO:0045893, GO:0030154, GO:0045214, GO:0030097, GO:0035050, GO:0010735, GO:0010736, GO:0010765, GO:0060413, GO:0060412, GO:0060347, GO:0010667, GO:0060037, GO:0060043, GO:0007512, GO:0048536, GO:0003166, GO:0003168, GO:0003162, GO:0003161, GO:0003151, GO:0003148, GO:0003211, GO:0003222, GO:0003208, GO:0003285, GO:0003278, GO:0003342, GO:0003350, GO:0030878, GO:0055117, GO:0055015, GO:0055005, GO:0055008, GO:0055014, GO:0090090, GO:0001947, GO:0051929, GO:0045666, GO:0051891, GO:0001570, GO:0044212, GO:0045885, GO:0060971, GO:0060928, GO:0060929, GO:0010832, GO:0032355, GO:0072358, GO:0003221 |
| InterPro ID |
IPR001356, IPR020479 |
| Gene Ontology Term |
DNA binding, negative regulation of transcription, DNA-dependent, protein binding, cardiac muscle cell differentiation, regulation of transcription, DNA-dependent, cytoplasm, embryonic heart tube development, transcription, DNA-dependent, positive regulation of cell proliferation, positive regulation of gene expression, BMP signaling pathway, negative regulation of apoptosis, heart morphogenesis, positive regulation of heart contraction, cardiac muscle tissue development, transcription factor binding, cell differentiation, sequence-specific DNA binding, hemopoiesis, positive regulation of transcription from RNA polymerase II promoter, sarcomere organization, cardiac muscle contraction, multicellular organismal development, nucleus, heart development, protein heterodimerization activity, canonical Wnt receptor signaling pathway, transcription factor complex, positive regulation of transcription initiation from RNA polymerase II promoter, chromatin binding, protein homodimerization activity, negative regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, cardiac ventricle morphogenesis, regulation of cardiac muscle cell proliferation, negative regulation of cardiac muscle cell apoptosis, outflow tract morphogenesis, atrial septum morphogenesis, pharyngeal system development, positive regulation of neuron differentiation, atrioventricular node cell development, serum response element binding, cardiac ventricle formation, outflow tract septum morphogenesis, proepicardium development, adult heart development, negative regulation of myotube differentiation, septum secundum development, pulmonary myocardium development, positive regulation of cardioblast differentiation, positive regulation of survival gene product expression, heart trabecula formation, cardiac muscle tissue morphogenesis, cardiac conduction system development, ventricular cardiac myofibril development, spleen development, vasculogenesis, atrioventricular node cell fate commitment, regulation of cardiac muscle contraction, atrial cardiac muscle cell development, cardiac Purkinje fiber cell differentiation, apoptosis involved in heart morphogenesis, ventricular septum morphogenesis, response to estradiol stimulus, positive regulation of calcium ion transport via voltage-gated calcium channel activity, ventricular trabecular myocardium morphogenesis, positive regulation of transcription via serum response element binding, thyroid gland development, bundle of His development, negative regulation of canonical Wnt receptor signaling pathway, atrioventricular node development, heart looping, embryonic heart tube left/right pattern formation, positive regulation of sodium ion transport, ventricular cardiac muscle cell development, sequence-specific DNA binding transcription factor activity, right ventricular cardiac muscle tissue morphogenesis, cardiovascular system development, transcription regulatory region DNA binding, sequence-specific distal enhancer binding RNA polymerase II transcription factor activity |
| InterPro Term |
Homeobox, Homeobox_eu |
| Ensembl Family Description |
HOMEOBOX NKX 2 HOMEOBOX NK 2 HOMOLOG |
| Ensembl Family |
ENSFM00600000921316 |
| EMBL-Bank ID |
BC025711, AB021133, EF122304, EF122305, EF122303, EF122309, EF122328, EF122329, EF122326, EF122324, EF122322, EF122321, EF122320, EF122318, EF122314, EF122315, EF122317, EF122311, EF122310, EF122313, EF122344, EF122345, EF122342, EF122343, EF122348, EF122349, EF122346, EF122347, EF122340, EF122341, EF122339, EF122330, EF122332, EF122333, EF122334, EF122335, EF122337, EF122368, EF122369, EF122366, EF122367, EF122364, EF122365, EF122362, EF122363, EF122360, EF122361, EF122358, EF122359, EF122354, EF122355, EF122356, EF122357, EF122350, EF122351, EF122352, EF122353, U34962, AK297844, AK290615, CH471062, EF122370, EF122371, EF122372, EF122373, EF122374, EF122375, EF122376, EF122377, EF122378, EF122379, AC008412 |
| Ensembl Protein ID |
ENSP00000429905, ENSP00000427906, ENSP00000327758, ENSP00000395378 |
| UniProt Accession |
A1ECB8, P52952, B4DNB6, E5RH49, E9PBU6 |
| Gene-Disease Assocation |
TETRALOGY OF FALLOT, ATRIAL SEPTAL DEFECT WITH ATRIOVENTRICULAR CONDUCTION DEFECTS, HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 5; CHNG5 |
| Entrez Gene ID |
1482 |
| RefSeq ID |
NM_001166176, NM_001166175, NM_004387, NP_001159647, NP_001159648, NP_004378 |
| UniGene ID |
Hs.54473 |
| Ensembl Gene ID |
ENSG00000183072 |
| HGNC Symbol |
NKX2-5 |
| Ensembl Transcript ID |
ENST00000329198, ENST00000424406, ENST00000521848, ENST00000517440 |
| Description |
NK2 homeobox 5 [Source:HGNC Symbol;Acc:2488] |
| Design Element |
ENST00000517440, U34962_at, 33570_at, ENST00000329198, ENST00000424406, 206578_at, g4758089_3p_at, ENST00000521848 |
| Search EB-eye |
ENSG00000183072
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