LCK
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Homo sapiens |
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LCK is differentially expressed in 266 experiments: 112 organism parts: bone marrow, thymus, ... (110 more);, 218 disease states: normal, prostate carcinoma, ... (216 more);, 125 cell types 457 cell lines 30 compound treatments and 67 other conditions. |
| Orthologs |
Lck
(Rattus norvegicus)
Q3ZCM0_BOVIN
(Bos taurus)
Lck
(Mus musculus)
lck
(Danio rerio)
lck
(Xenopus laevis)
LCK
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001452, IPR011511, IPR001245, IPR017442, IPR000719, IPR000980, IPR020635 |
| Gene Ontology Term |
cytosol, response to hydrogen peroxide, plasma membrane, endocytic vesicle, protein binding, apoptosis, SH2 domain binding, cytoplasm, pericentriolar material, peptidyl-tyrosine phosphorylation, Golgi apparatus, protein serine/threonine phosphatase activity, activation of caspase activity, protein tyrosine kinase activity, blood coagulation, membrane raft, protein tyrosine phosphatase activity, hemopoiesis, ATP binding, induction of apoptosis, cell surface receptor linked signaling pathway, protein kinase binding, response to zinc ion, aging, nucleotide binding, response to metal ion, protein serine/threonine kinase activity, response to drug, protein C-terminus binding, non-membrane spanning protein tyrosine kinase activity, release of sequestered calcium ion into cytosol, response to mechanical stimulus, protein kinase activity, viral reproduction, T cell receptor signaling pathway, positive regulation of T cell activation, antigen binding, cellular zinc ion homeostasis, positive regulation of uterine smooth muscle contraction, B cell receptor signaling pathway, leukocyte migration, ATPase binding, peptidyl-tyrosine dephosphorylation, positive regulation of gamma-delta T cell differentiation, positive regulation of tyrosine phosphorylation of Stat5 protein, interspecies interaction between organisms, glycoprotein binding, regulation of T cell receptor signaling pathway, protein complex binding, T cell costimulation, CD4 receptor binding, T cell differentiation, platelet activation, positive regulation of T cell receptor signaling pathway, protein autophosphorylation, protein phosphorylation, regulation of lymphocyte activation, regulation of defense response to virus by virus, CD8 receptor binding, phosphatidylinositol 3-kinase binding |
| InterPro Term |
SH2, SH3_domain, Prot_kinase_cat_dom, SH3_2, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Gene Ontology ID |
GO:0008022, GO:0007166, GO:0009612, GO:0010043, GO:0010038, GO:0007568, GO:0007596, GO:0051209, GO:0042493, GO:0042542, GO:0004713, GO:0004715, GO:0004725, GO:0004722, GO:0005524, GO:0005515, GO:0006915, GO:0006919, GO:0006917, GO:0005737, GO:0005886, GO:0005829, GO:0005794, GO:0004672, GO:0004674, GO:0019901, GO:0006468, GO:0000166, GO:0018108, GO:0046777, GO:0042169, GO:0000242, GO:0043548, GO:0030139, GO:0045121, GO:0030097, GO:0016032, GO:0003823, GO:0051117, GO:0042523, GO:0042609, GO:0006882, GO:0032403, GO:0031295, GO:0001948, GO:0050870, GO:0050862, GO:0050856, GO:0050852, GO:0050853, GO:0044419, GO:0045588, GO:0030168, GO:0035335, GO:0070474, GO:0030217, GO:0050900, GO:0051249, GO:0042610, GO:0050690 |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 |
| Ensembl Protein ID |
ENSP00000328213, ENSP00000337825, ENSP00000362658, ENSP00000362665, ENSP00000362663, ENSP00000381387, ENSP00000400092, ENSP00000436554, ENSP00000431517, ENSP00000435605, ENSP00000434525 |
| RefSeq ID |
NM_005356, NM_001042771, NP_005347, NP_001036236 |
| EMBL-Bank ID |
X13529, X06369, U23852, M26692, AK098027, AF228313, M36881, CH471059, X04476, M21510, AL109945, AL121991, U07236, X14053, X14054, X14055, BC013200, AJ865079, X05027, BN000073 |
| Description |
lymphocyte-specific protein tyrosine kinase [Source:HGNC Symbol;Acc:6524] |
| UniGene ID |
Hs.470627 |
| Ensembl Gene ID |
ENSG00000182866 |
| UniProt Accession |
P06239, Q573B4, B3KUV3, E9PQ10, E7EN21, E9PAP0, E9PI33, E9PJ92, E9PKQ8, F8W6B9 |
| Entrez Gene ID |
3932 |
| HGNC Symbol |
LCK |
| Ensembl Family |
ENSFM00640001103053 |
| Ensembl Transcript ID |
ENST00000469765, ENST00000355928, ENST00000482949, ENST00000469956, ENST00000373557, ENST00000373564, ENST00000373562, ENST00000495610, ENST00000436824, ENST00000476457, ENST00000336890, ENST00000477031, ENST00000333070, ENST00000398345, ENST00000461712 |
| Design Element |
1266_s_at, 33238_at, ENST00000436824, ENST00000373557, ENST00000336890, g460965_3p_s_at, g4885448_3p_s_at, ENST00000469765, ENST00000398345, ENST00000495610, ENST00000333070, ENST00000477031, 204890_s_at, 204891_3p_s_at, g4885448_3p_at, 204891_s_at, ENST00000373562, ENST00000482949, U23852_s_at, ENST00000373564, ENST00000476457, ENST00000355928, ENST00000469956, 2059_s_at, M26692_s_at, ENST00000461712 |
| Search EB-eye |
ENSG00000182866
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