PTPN11
close
Please copy/paste those URLs into your code to get same results in machine-readable formats:
|
Homo sapiens |
|
PTPN11 is differentially expressed in 350 experiments: 156 organism parts: bone marrow, liver, ... (154 more);, 254 disease states: normal, cervical carcinoma, ... (252 more);, 104 cell types 421 cell lines 45 compound treatments and 85 other conditions. |
| Synonyms |
SHP-2, NS1, BPTP3, SHP2, PTP2C, SH-PTP2 |
| Orthologs |
ENSCING00000003686
(Ciona intestinalis)
ENSCING00000016529
(Ciona intestinalis)
Ptpn11
(Mus musculus)
Ptpn11
(Rattus norvegicus)
PTPN11
(Bos taurus)
ptpn11a
(Danio rerio)
csw
(Drosophila melanogaster)
PTPN11
(Gallus gallus)
PTPN11
(Xenopus laevis)
PTPN11
(Canis familiaris)
(Compare orthologs)
|
| Gene Ontology Term |
regulation of multicellular organism growth, cytosol, phosphatase activity, DNA damage checkpoint, protein binding, cytokine-mediated signaling pathway, cytoplasm, epidermal growth factor receptor signaling pathway, protein complex, dephosphorylation, hormone-mediated signaling pathway, insulin receptor binding, phosphoprotein phosphatase activity, insulin receptor signaling pathway, insulin receptor substrate binding, blood coagulation, protein domain specific binding, glucose homeostasis, fibroblast growth factor receptor signaling pathway, organ growth, activation of MAPK activity, soluble fraction, protein tyrosine phosphatase activity, axon guidance, triglyceride metabolic process, lipid metabolic process, axonogenesis, hydrolase activity, non-membrane spanning protein tyrosine phosphatase activity, positive regulation of hormone secretion, regulation of cell adhesion mediated by integrin, mitochondrion, regulation of interferon-gamma-mediated signaling pathway, hormone metabolic process, leukocyte migration, regulation of type I interferon-mediated signaling pathway, negative regulation of hormone secretion, peptidyl-tyrosine dephosphorylation, negative regulation of growth hormone secretion, ephrin receptor signaling pathway, negative regulation of insulin secretion, negative regulation of cortisol secretion, regulation of protein export from nucleus, positive regulation of signal transduction, nerve growth factor receptor signaling pathway, peptide hormone receptor binding, phospholipase binding, T cell costimulation, platelet activation, protein dephosphorylation, interferon-gamma-mediated signaling pathway, type I interferon-mediated signaling pathway, multicellular organismal reproductive process, cell junction assembly |
| InterPro Term |
SH2, Tyr_Pase_cat, Tyr_Pase_rcpt/non-rcpt, Tyr_Pase_non-rcpt_typ-6/11, Tyr/Dual-specificity_Pase |
| Gene Ontology ID |
GO:0008286, GO:0007173, GO:0016311, GO:0009755, GO:0008543, GO:0007411, GO:0007409, GO:0007596, GO:0042593, GO:0016791, GO:0016787, GO:0000077, GO:0004725, GO:0004726, GO:0004721, GO:0005625, GO:0005515, GO:0005737, GO:0005739, GO:0005829, GO:0005158, GO:0006641, GO:0040014, GO:0006629, GO:0019904, GO:0006470, GO:0000187, GO:0046887, GO:0019221, GO:0043234, GO:0043560, GO:0033628, GO:0035265, GO:0048011, GO:0048013, GO:0060338, GO:0060334, GO:0009967, GO:0060125, GO:0051428, GO:0042445, GO:0048609, GO:0031295, GO:0046825, GO:0046888, GO:0043274, GO:0051463, GO:0046676, GO:0030168, GO:0035335, GO:0050900, GO:0060333, GO:0060337, GO:0034329 |
| InterPro ID |
IPR000242, IPR000980, IPR000387, IPR003595, IPR012152 |
| Ensembl Family Description |
TYROSINE PHOSPHATASE NON RECEPTOR TYPE 11 EC_3.1.3.48 TYROSINE PHOSPHATASE SH PTP2 SHP 2 SHP2 |
| Ensembl Family |
ENSFM00260000050462 |
| Description |
protein tyrosine phosphatase, non-receptor type 11 [Source:HGNC Symbol;Acc:9644] |
| EMBL-Bank ID |
D13540, BT007106, X70766, L08807, CH471054, EU779707, EU779706, L07527, BC008692, AK289854, L03535 |
| UniGene ID |
Hs.713661, Hs.682780, Hs.627572, Hs.506852 |
| HGNC Symbol |
PTPN11 |
| Ensembl Protein ID |
ENSP00000340944, ENSP00000376376, ENSP00000376375, ENSP00000437013 |
| UniProt Accession |
Q06124, B3GUD3, B3GUD4 |
| RefSeq ID |
NP_002825, NM_002834 |
| Ensembl Gene ID |
ENSG00000179295 |
| Gene-Disease Assocation |
LEOPARD SYNDROME 1, METACHONDROMATOSIS, JUVENILE MYELOMONOCYTIC LEUKEMIA; JMML, NOONAN SYNDROME 1; NS1 |
| Entrez Gene ID |
5781 |
| Ensembl Transcript ID |
ENST00000530818, ENST00000531326, ENST00000351677, ENST00000392596, ENST00000392597 |
| Design Element |
1871_g_at, g13430845_3p_at, ENST00000530818, 205868_s_at, g7770146_RC_3p_at, 209895_at, ENST00000392597, ENST00000392596, g292406_3p_a_at, ENST00000531326, 205867_at, Hs2.22868.1.S1_3p_at, ENST00000351677, 212610_at, gnf1h09380_s_at, 38443_at, U79291_at, 1870_at, Hs.83572.0.S1_3p_at, D13540_at, 209896_s_at, 1552637_at |
| Search EB-eye |
ENSG00000179295
|
 Show more
properties
|
|
