ATR
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Homo sapiens |
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ATR is differentially expressed in 298 experiments: 120 organism parts: kidney, liver, ... (118 more);, 206 disease states: normal, control, ... (204 more);, 87 cell types 346 cell lines 36 compound treatments and 69 other conditions. |
| Synonyms |
FRP1, MEC1, SCKL1, SCKL |
| Orthologs |
MEC1
(Saccharomyces cerevisiae)
ATR
(Gallus gallus)
Atr
(Rattus norvegicus)
ATR
(Bos taurus)
Atr
(Mus musculus)
ENSCING00000004150
(Ciona intestinalis)
atr
(Danio rerio)
mei-41
(Drosophila melanogaster)
atr
(Xenopus laevis)
ATR
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008156, GO:0003677, GO:0007049, GO:0007275, GO:0016773, GO:0000077, GO:0000075, GO:0005524, GO:0005515, GO:0005634, GO:0005654, GO:0006974, GO:0004672, GO:0004674, GO:0006468, GO:0000166, GO:0018105, GO:0046777, GO:0006281, GO:0006260, GO:0016605, GO:0032405, GO:0032407, GO:0043393, GO:0001741, GO:0043517, GO:0071480, GO:0034644, GO:0090399 |
| InterPro Term |
HEAT_type_2, UME, PIK_FAT, PIK-rel_kinase_FAT, FATC, PI3/4_kinase_cat |
| Gene Ontology Term |
DNA damage checkpoint, DNA binding, protein binding, phosphotransferase activity, alcohol group as acceptor, DNA repair, peptidyl-serine phosphorylation, negative regulation of DNA replication, ATP binding, cell cycle, multicellular organismal development, nucleus, nucleotide binding, protein serine/threonine kinase activity, nucleoplasm, cell cycle checkpoint, response to DNA damage stimulus, DNA replication, protein kinase activity, cellular response to gamma radiation, MutLalpha complex binding, regulation of protein binding, XY body, MutSalpha complex binding, PML body, cellular response to UV, positive regulation of DNA damage response, signal transduction by p53 class mediator, protein autophosphorylation, protein phosphorylation, replicative senescence |
| InterPro ID |
IPR012993, IPR000403, IPR014009, IPR021133, IPR003152, IPR003151 |
| Ensembl Family |
ENSFM00360000109942 |
| Ensembl Family Description |
SERINE/THREONINE KINASE MEC1 EC_2.7.11.1 ATR HOMOLOG DNA DAMAGE CHECKPOINT KINASE MEC1 MITOSIS ENTRY CHECKPOINT 1 |
| Description |
ataxia telangiectasia and Rad3 related [Source:HGNC Symbol;Acc:882] |
| EMBL-Bank ID |
U49844, AC109992, AC134509, Y09077, AF325699, AB208847, U76308 |
| RefSeq ID |
NP_001175, NM_001184 |
| Ensembl Protein ID |
ENSP00000372581, ENSP00000422553, ENSP00000424754, ENSP00000424355, ENSP00000421870, ENSP00000426595, ENSP00000343741, ENSP00000425897 |
| UniProt Accession |
Q13535, D6RIG7, D6RFJ6 |
| UniGene ID |
Hs.271791 |
| HGNC Symbol |
ATR |
| Ensembl Gene ID |
ENSG00000175054 |
| Entrez Gene ID |
545 |
| Ensembl Transcript ID |
ENST00000513291, ENST00000507620, ENST00000350721, ENST00000511016, ENST00000383101, ENST00000514393, ENST00000504521, ENST00000515149, ENST00000515107, ENST00000515810, ENST00000515863, ENST00000507148 |
| Gene-Disease Assocation |
SECKEL SYNDROME 1; SCKL1 |
| Design Element |
209902_at, ENST00000504521, U49844_at, ENST00000515863, ENST00000511016, Hs.301081.0.S1_3p_at, ENST00000513291, 209903_s_at, ENST00000515107, ENST00000515810, ENST00000507620, ENST00000350721, ENST00000514393, ENST00000383101, g1235901_3p_a_at, 233288_at, ENST00000515149, ENST00000507148, 37229_at |
| Search EB-eye |
ENSG00000175054
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