BCL2
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Homo sapiens |
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BCL2 is differentially expressed in 353 experiments: 144 organism parts: bone marrow, lung, ... (142 more);, 245 disease states: normal, colon carcinoma, ... (243 more);, 140 cell types 453 cell lines 49 compound treatments and 78 other conditions. |
| Synonyms |
Bcl-2 |
| Orthologs |
BCL2_CHICK
(Gallus gallus)
BCL2 (1 of 2)
(Danio rerio)
BCL2 (2 of 2)
(Danio rerio)
Bcl2
(Mus musculus)
ENSCING00000013537
(Ciona intestinalis)
BCL2
(Bos taurus)
Bcl2
(Rattus norvegicus)
bcl2
(Xenopus laevis)
BCL2
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008134, GO:0009887, GO:0008219, GO:0048041, GO:0048066, GO:0048070, GO:0008283, GO:0008285, GO:0016049, GO:0016020, GO:0010468, GO:0010332, GO:0009408, GO:0007015, GO:0009636, GO:0016337, GO:0009791, GO:0008584, GO:0042221, GO:0007420, GO:0051402, GO:0007409, GO:0031965, GO:0031966, GO:0007584, GO:0007568, GO:0042493, GO:0048589, GO:0048599, GO:0042542, GO:0048546, GO:0000082, GO:0042803, GO:0042802, GO:0005622, GO:0005624, GO:0005515, GO:0015267, GO:0006916, GO:0006915, GO:0006959, GO:0006950, GO:0005737, GO:0005739, GO:0005741, GO:0005634, GO:0006874, GO:0005829, GO:0005789, GO:0005783, GO:0005792, GO:0048087, GO:0006979, GO:0006974, GO:0042981, GO:0040018, GO:0040007, GO:0043085, GO:0043066, GO:0043067, GO:0050790, GO:0001952, GO:0051924, GO:0031000, GO:0006470, GO:0000902, GO:0031625, GO:0031647, GO:0018105, GO:0018107, GO:0051721, GO:0051726, GO:0032880, GO:0046930, GO:0046982, GO:0000209, GO:0045930, GO:0043524, GO:0043565, GO:0051607, GO:0001666, GO:0046688, GO:0030097, GO:0045471, GO:0030308, GO:0030307, GO:0030336, GO:0034349, GO:0009314, GO:0045087, GO:0035265, GO:0034097, GO:0002020, GO:0010559, GO:0010523, GO:0008629, GO:0008633, GO:0010224, GO:0009605, GO:0010044, GO:0010039, GO:0010035, GO:0010033, GO:0051384, GO:0051434, GO:0051400, GO:0051412, GO:0048873, GO:0007569, GO:0007565, GO:0048709, GO:0048753, GO:0048743, GO:0001101, GO:0002520, GO:0048536, GO:0048538, GO:0048545, GO:0003014, GO:0014070, GO:0002360, GO:0014031, GO:0014042, GO:0002326, GO:0002320, GO:0043627, GO:0002218, GO:0002260, GO:0030890, GO:0032469, GO:0006808, GO:0006582, GO:0019903, GO:0031103, GO:0050853, GO:0043029, GO:0032848, GO:0032868, GO:0032835, GO:0042100, GO:0001776, GO:0001782, GO:0043375, GO:0046902, GO:0045636, GO:0051881, GO:0001836, GO:0001822, GO:0043209, GO:0014911, GO:0001541, GO:0001503, GO:0043583, GO:0043496, GO:0043497, GO:0001662, GO:0001658, GO:0001656, GO:0001657, GO:0046671, GO:0043434, GO:0051593, GO:0030183, GO:0033689, GO:0022612, GO:0021747, GO:0030318, GO:0030279, GO:0033591, GO:0030217, GO:0033138, GO:0035094, GO:0070059, GO:0033077, GO:0033033, GO:0051902, GO:0022898, GO:0072593 |
| Gene Ontology Term |
defense response to virus, humoral immune response, cytosol, response to hydrogen peroxide, negative regulation of cell growth, positive regulation of developmental pigmentation, response to oxidative stress, negative regulation of mitotic cell cycle, endoplasmic reticulum, response to copper ion, protein binding, apoptosis, digestive tract morphogenesis, regulation of calcium ion transport, cytoplasm, cell-cell adhesion, positive regulation of catalytic activity, cell proliferation, intracellular, regulation of cell-matrix adhesion, negative regulation of cell proliferation, peptidyl-serine phosphorylation, innate immune response, response to toxin, focal adhesion assembly, regulation of catalytic activity, membrane, developmental growth, response to chemical stimulus, negative regulation of apoptosis, regulation of protein stability, response to stress, male gonad development, positive regulation of multicellular organism growth, anti-apoptosis, response to hypoxia, cell morphogenesis, actin filament organization, membrane fraction, regulation of protein localization, oocyte development, mitochondrial outer membrane, organ growth, transcription factor binding, pore complex, cell growth, protein phosphatase 2A binding, sequence-specific DNA binding, developmental pigmentation, response to nutrient, identical protein binding, hemopoiesis, growth, microsome, cellular calcium ion homeostasis, regulation of cell cycle, G1/S transition of mitotic cell cycle, nucleus, protein polyubiquitination, negative regulation of cell migration, response to caffeine, protein heterodimerization activity, regulation of gene expression, aging, cell death, mitochondrial membrane, channel activity, post-embryonic development, regulation of programmed cell death, response to drug, axonogenesis, protein homodimerization activity, positive regulation of cell growth, response to DNA damage stimulus, response to gamma radiation, response to ethanol, regulation of developmental pigmentation, peptidyl-threonine phosphorylation, brain development, endoplasmic reticulum membrane, response to heat, response to radiation, neuron apoptosis, organ morphogenesis, nuclear membrane, mitochondrion, regulation of apoptosis, ubiquitin protein ligase binding, negative regulation of neuron apoptosis, glial cell apoptosis, protease binding, response to corticosterone stimulus, myelin sheath, female pregnancy, B cell differentiation, response to cytokine stimulus, positive regulation of peptidyl-serine phosphorylation, negative regulation of ossification, activation of pro-apoptotic gene products, positive regulation of B cell proliferation, behavioral fear response, oligodendrocyte differentiation, cell aging, BH domain binding, B cell receptor signaling pathway, positive regulation of smooth muscle cell migration, negative regulation of osteoblast proliferation, kidney development, branching involved in ureteric bud morphogenesis, response to iron ion, response to nicotine, activation of innate immune response, B cell proliferation, negative regulation of retinal cell programmed cell death, T cell lineage commitment, axon regeneration, induction of apoptosis by intracellular signals, cochlear nucleus development, melanocyte differentiation, response to UV-B, melanin metabolic process, ossification, response to estrogen stimulus, endoplasmic reticulum calcium ion homeostasis, spleen development, lymphoid progenitor cell differentiation, apoptosis in response to endoplasmic reticulum stress, B cell homeostasis, negative regulation of cellular pH reduction, metanephros development, ovarian follicle development, BH3 domain binding, gland morphogenesis, regulation of glycoprotein biosynthetic process, response to inorganic substance, response to external stimulus, regulation of protein heterodimerization activity, ear development, homeostasis of number of cells within a tissue, leukocyte homeostasis, immune system development, response to insulin stimulus, response to peptide hormone stimulus, T cell homeostasis, release of cytochrome c from mitochondria, regulation of mitochondrial membrane potential, glomerulus development, regulation of protein homodimerization activity, response to acid, mesenchymal cell development, CD8-positive, alpha-beta T cell lineage commitment, response to organic substance, protein phosphatase binding, positive regulation of skeletal muscle fiber development, response to folic acid, thymus development, positive regulation of neuron maturation, T cell differentiation, renal system process, ureteric bud development, response to L-ascorbic acid, response to steroid hormone stimulus, B cell lineage commitment, regulation of nitrogen utilization, lymphocyte homeostasis, pigment granule organization, response to aluminum ion, negative regulation of calcium ion transport into cytosol, response to glucocorticoid stimulus, positive regulation of melanocyte differentiation, negative regulation of myeloid cell apoptosis, regulation of mitochondrial membrane permeability, protein dephosphorylation, T cell differentiation in thymus, negative regulation of mitochondrial depolarization, regulation of transmembrane transporter activity, response to organic cyclic compound, reactive oxygen species metabolic process |
| InterPro Term |
Apop_reg_Bcl2, Apop_reg_BclX, Bcl2_BH, Bcl2_BH4, Bcl2_reg, Bcl2-like_apoptosis |
| InterPro ID |
IPR002475, IPR000712, IPR013279, IPR013278, IPR003093, IPR004725 |
| Ensembl Family |
ENSFM00500000271823 |
| Ensembl Family Description |
APOPTOSIS REGULATOR BCL 2 |
| UniProt Accession |
Q96PA0, P10415, C9JHD5 |
| EMBL-Bank ID |
M14745, AY220759, X06487, AC022726, AF401211, CH471096, AC021803, M13995, M13994, S72602, BC027258 |
| Ensembl Gene ID |
ENSG00000171791 |
| UniGene ID |
Hs.150749, Hs.709992 |
| Description |
B-cell CLL/lymphoma 2 [Source:HGNC Symbol;Acc:990] |
| HGNC Symbol |
BCL2 |
| Ensembl Protein ID |
ENSP00000381185, ENSP00000329623, ENSP00000404214 |
| RefSeq ID |
NM_000633, NM_000657, NP_000648, NP_000624 |
| Entrez Gene ID |
596 |
| Gene-Disease Assocation |
B-CELL CLL/LYMPHOMA 2; BCL2 |
| Ensembl Transcript ID |
ENST00000444484, ENST00000398117, ENST00000333681 |
| Design Element |
ENST00000444484, g4557356_3p_a_at, M14745_at, 1909_at, g4557354_3p_at, g4557356_3p_x_at, 207005_s_at, ENST00000398117, 1910_s_at, 2038_g_at, 1847_s_at, 203685_at, M13994_s_at, 203684_s_at, ENST00000333681, g179366_3p_a_at |
| Search EB-eye |
ENSG00000171791
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