ALK
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Homo sapiens |
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ALK is differentially expressed in 184 experiments: 125 organism parts: lung, prostate, ... (123 more);, 143 disease states: normal, acute promyelocytic leukemia, ... (141 more);, 54 cell types 127 cell lines 18 compound treatments and 64 other conditions. |
| Synonyms |
CD246 |
| Orthologs |
F1MUQ3_BOVIN
(Bos taurus)
Alk
(Rattus norvegicus)
F1NHS4_CHICK
(Gallus gallus)
Alk
(Mus musculus)
Alk
(Drosophila melanogaster)
alk
(Danio rerio)
ALK
(Xenopus laevis)
ALK
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR000998, IPR002172, IPR020635 |
| Gene Ontology ID |
GO:0008283, GO:0016020, GO:0007169, GO:0007165, GO:0016310, GO:0048666, GO:0051092, GO:0004713, GO:0004714, GO:0005524, GO:0005515, GO:0004872, GO:0005887, GO:0004672, GO:0004674, GO:0042981, GO:0006468, GO:0000166, GO:0000187, GO:0046777, GO:0004704 |
| Gene Ontology Term |
phosphorylation, protein binding, cell proliferation, membrane, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway, activation of MAPK activity, ATP binding, integral to plasma membrane, receptor activity, neuron development, nucleotide binding, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, positive regulation of NF-kappaB transcription factor activity, signal transduction, protein kinase activity, regulation of apoptosis, NF-kappaB-inducing kinase activity, protein autophosphorylation, protein phosphorylation |
| Ensembl Family |
ENSFM00500000270379 |
| Ensembl Family Description |
PROTO ONCOGENE TYROSINE KINASE ROS PRECURSOR EC_2.7.10.1 PROTO ONCOGENE C ROS 1 |
| InterPro Term |
Prot_kinase_cat_dom, MAM_dom, LDrepeatLR_classA_rpt, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Description |
anaplastic lymphoma receptor tyrosine kinase [Source:HGNC Symbol;Acc:427] |
| EMBL-Bank ID |
AC074096, AC098874, U62540, AB209477, AC093756, AC106870, AC106899, U66559, EU660517 |
| Ensembl Gene ID |
ENSG00000171094 |
| UniProt Accession |
Q580I3, Q9UM73, B2MXD7, E7EPW7 |
| Ensembl Protein ID |
ENSP00000414027, ENSP00000387488, ENSP00000373700 |
| UniGene ID |
Hs.654469 |
| RefSeq ID |
NM_004304, NP_004295 |
| HGNC Symbol |
ALK |
| Gene-Disease Assocation |
NEUROBLASTOMA, SUSCEPTIBILITY TO, NEUROBLASTOMA, SUSCEPTIBILITY TO, 3; NBLST3 |
| Entrez Gene ID |
238 |
| Ensembl Transcript ID |
ENST00000431873, ENST00000453137, ENST00000389048, ENST00000498037 |
| Design Element |
208212_s_at, 38543_at, 451_at, ENST00000453137, ENST00000431873, g1848243_3p_a_at, 208211_s_at, gnf1h03839_s_at, U66559_at, ENST00000389048, ENST00000498037, 66494_at |
| Search EB-eye |
ENSG00000171094
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