CTNNB1
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Homo sapiens |
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CTNNB1 is differentially expressed in 279 experiments: 132 organism parts: bone marrow, lung, ... (130 more);, 174 disease states: normal, acute myeloid leukemia, ... (172 more);, 82 cell types 361 cell lines 36 compound treatments and 70 other conditions. |
| Synonyms |
CTNNB, beta-catenin |
| Orthologs |
CTNB1_BOVIN
(Bos taurus)
Q9NL44_CIOIN
(Ciona intestinalis)
CTNNB1
(Gallus gallus)
Ctnnb1
(Rattus norvegicus)
Ctnnb1
(Mus musculus)
VAC8
(Saccharomyces cerevisiae)
arm
(Drosophila melanogaster)
ctnnb1
(Xenopus laevis)
B6V8E6_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008134, GO:0060439, GO:0016055, GO:0003682, GO:0003677, GO:0009948, GO:0003690, GO:0010628, GO:0009953, GO:0009954, GO:0009950, GO:0008283, GO:0008285, GO:0008284, GO:0009987, GO:0016020, GO:0003713, GO:0003700, GO:0008022, GO:0060070, GO:0007016, GO:0007155, GO:0007160, GO:0007268, GO:0016331, GO:0016337, GO:0016328, GO:0016323, GO:0009725, GO:0007398, GO:0005938, GO:0007494, GO:0005912, GO:0005911, GO:0005913, GO:0005915, GO:0007403, GO:0007507, GO:0042493, GO:0030539, GO:0048617, GO:0048599, GO:0048489, GO:0048471, GO:0042692, GO:0005624, GO:0005515, GO:0004871, GO:0006915, GO:0048262, GO:0005737, GO:0005634, GO:0005667, GO:0005886, GO:0005856, GO:0005829, GO:0005813, GO:0042981, GO:0000578, GO:0005198, GO:0046332, GO:0043065, GO:0043066, GO:0019901, GO:0019900, GO:0000922, GO:0000904, GO:0050808, GO:0043005, GO:0019899, GO:0000122, GO:0042127, GO:0006355, GO:0006357, GO:0006351, GO:0001709, GO:0001708, GO:0001706, GO:0043296, GO:0043234, GO:0045596, GO:0045595, GO:0001837, GO:0045944, GO:0045892, GO:0045893, GO:0046686, GO:0030154, GO:0045296, GO:0045202, GO:0030018, GO:0030027, GO:0045177, GO:0030097, GO:0030054, GO:0070491, GO:0035050, GO:0009898, GO:0060479, GO:0060492, GO:0060484, GO:0034097, GO:0060440, GO:0060441, GO:0072053, GO:0072054, GO:0072079, GO:0072001, GO:0072033, GO:0022009, GO:0060066, GO:0022405, GO:0016342, GO:0060173, GO:0005916, GO:0005924, GO:0048715, GO:0051149, GO:0051145, GO:0042475, GO:0030521, GO:0048660, GO:0048513, GO:0048538, GO:0048469, GO:0061154, GO:0003136, GO:0014070, GO:0014010, GO:0042733, GO:0061047, GO:0043627, GO:0003337, GO:0003338, GO:0030997, GO:0030902, GO:0030900, GO:0048145, GO:0002053, GO:0002089, GO:0030856, GO:0030858, GO:0031253, GO:0050681, GO:0019903, GO:0043123, GO:0031016, GO:0031069, GO:0045743, GO:0031641, GO:0045765, GO:0045768, GO:0042129, GO:0001701, GO:0001702, GO:0042153, GO:0001711, GO:0045603, GO:0045670, GO:0045671, GO:0045667, GO:0045669, GO:0032993, GO:0070602, GO:0043198, GO:0001889, GO:0001822, GO:0001570, GO:0001569, GO:0001501, GO:0043588, GO:0043587, GO:0044212, GO:0031528, GO:0001658, GO:0043410, GO:0045294, GO:0071407, GO:0030057, GO:0071363, GO:0045453, GO:0045445, GO:0070412, GO:0070411, GO:0060742, GO:0030331, GO:0060769, GO:0030316, GO:0060789, GO:0030324, GO:0030326, GO:0070369, GO:0060916, GO:0030217, GO:0034394, GO:0034333, GO:0090279, GO:0035112, GO:0035117, GO:0035116, GO:0034613, GO:0071681, GO:0010909, GO:0033077, GO:0032331, GO:0032355, GO:0035255, GO:0035257, GO:0034747, GO:0006921, GO:0044334, GO:0044336, GO:0044325, GO:0046591, GO:0072182, GO:0071944, GO:0061198, GO:2000008, GO:2000017, GO:0003266, GO:0034742, GO:0034750 |
| Gene Ontology Term |
cytosol, plasma membrane, spindle pole, DNA binding, adherens junction, cell morphogenesis involved in differentiation, negative regulation of transcription, DNA-dependent, protein binding, apoptosis, cellular process, regulation of transcription, DNA-dependent, glial cell fate determination, cell-cell adherens junction, cytoskeleton, cytoplasm, cell-cell adhesion, embryonic heart tube development, double-stranded DNA binding, cell proliferation, regulation of cell proliferation, cadherin binding, cell cortex, negative regulation of cell proliferation, trachea morphogenesis, cell fate determination, cell-cell junction, determination of dorsal/ventral asymmetry, protein complex, transcription, DNA-dependent, positive regulation of cell proliferation, positive regulation of gene expression, membrane, negative regulation of apoptosis, endoderm formation, kinase binding, male genitalia development, structural molecule activity, embryonic foregut morphogenesis, cytoskeletal anchoring at plasma membrane, membrane fraction, cell fate specification, cell junction, proximal/distal pattern formation, positive regulation of apoptosis, oocyte development, signal transducer activity, transcription factor binding, cell differentiation, midgut development, synapse organization, synaptic vesicle transport, response to cadmium ion, basolateral plasma membrane, anterior/posterior axis specification, cell adhesion, hemopoiesis, neuron projection, positive regulation of transcription from RNA polymerase II promoter, Wnt receptor signaling pathway, zonula adherens, centrosome, synaptic transmission, cell-matrix adhesion, transcription coactivator activity, protein kinase binding, nucleus, muscle cell differentiation, heart development, lamellipodium, canonical Wnt receptor signaling pathway, regulation of cell differentiation, response to hormone stimulus, transcription factor complex, embryonic axis specification, response to drug, perinuclear region of cytoplasm, synapse, apical part of cell, chromatin binding, SMAD binding, protein C-terminus binding, negative regulation of transcription from RNA polymerase II promoter, negative regulation of cell differentiation, regulation of transcription from RNA polymerase II promoter, apical junction complex, ectoderm development, enzyme binding, epithelial to mesenchymal transition, lateral plasma membrane, positive regulation of transcription, DNA-dependent, morphogenesis of embryonic epithelium, dorsal/ventral axis specification, regulation of apoptosis, dorsal/ventral pattern formation, Z disc, positive regulation of mesenchymal cell proliferation, renal inner medulla development, cell-substrate adherens junction, endothelial tube morphogenesis, positive regulation of I-kappaB kinase/NF-kappaB cascade, regulation of smooth muscle cell proliferation, response to cytokine stimulus, androgen receptor binding, androgen receptor signaling pathway, genitalia morphogenesis, regulation of epithelial cell differentiation, endodermal cell fate commitment, internal side of plasma membrane, regulation of angiogenesis, RPTP-like protein binding, cellular response to growth factor stimulus, negative regulation of oligodendrocyte differentiation, regulation of calcium ion import, mesenchymal to epithelial transition involved in metanephros morphogenesis, regulation of T cell proliferation, epithelial tube branching involved in lung morphogenesis, lung induction, microvillus membrane, regulation of fibroblast proliferation, in utero embryonic development, kidney development, lens morphogenesis in camera-type eye, branching involved in ureteric bud morphogenesis, hindbrain development, embryonic hindlimb morphogenesis, limb development, negative regulation of osteoclast differentiation, adherens junction assembly, central nervous system vasculogenesis, forebrain development, gastrulation with mouth forming second, regulation of centromeric sister chromatid cohesion, trachea formation, lung-associated mesenchyme development, positive regulation of anti-apoptosis, cell projection membrane, hair follicle morphogenesis, response to estrogen stimulus, protein-DNA complex, positive regulation of branching involved in lung morphogenesis, alpha-catenin binding, pancreas development, vasculogenesis, myoblast differentiation, epithelial cell differentiation involved in prostate gland development, cellular response to indole-3-methanol, nephron tubule formation, metanephros morphogenesis, embryonic digit morphogenesis, nuclear hormone receptor binding, estrogen receptor binding, catenin complex, cell maturation, cellular protein localization, regulation of osteoblast differentiation, skin development, fascia adherens, renal outer medulla development, hair follicle placode formation, skeletal system development, negative regulation of chondrocyte differentiation, desmosome, regulation of centriole-centriole cohesion, regulation of osteoclast differentiation, regulation of myelination, positive regulation of endothelial cell differentiation, response to estradiol stimulus, organ development, lung development, tongue morphogenesis, positive regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of osteoblast differentiation, patterning of blood vessels, positive regulation of epithelial cell differentiation, lung cell differentiation, mesenchymal cell proliferation involved in lung development, liver development, bone resorption, beta-catenin-TCF7L2 complex, positive regulation of heparan sulfate proteoglycan biosynthetic process, ionotropic glutamate receptor binding, protein phosphatase binding, hair cycle process, thymus development, odontogenesis of dentine-containing tooth, smooth muscle cell differentiation, protein localization at cell surface, positive regulation of MAPKKK cascade, embryonic limb morphogenesis, renal system development, T cell differentiation, dendritic shaft, positive regulation of muscle cell differentiation, Axin-APC-beta-catenin-GSK3B complex, positive regulation of fibroblast growth factor receptor signaling pathway, R-SMAD binding, embryonic arm morphogenesis, renal vesicle formation, I-SMAD binding, Schwann cell proliferation, osteoclast differentiation, sequence-specific DNA binding transcription factor activity, T cell differentiation in thymus, cellular component disassembly involved in apoptosis, negative regulation of heart induction by canonical Wnt receptor signaling pathway, oviduct development, canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition, embryonic leg joint morphogenesis, regulation of nephron tubule epithelial cell differentiation, fungiform papilla formation, cell periphery, positive regulation of determination of dorsal identity, Scrib-APC-beta-catenin complex, response to organic cyclic compound, regulation of protein localization at cell surface, canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis, APC-Axin-1-beta-catenin complex, regulation of secondary heart field cardioblast proliferation, cellular response to organic cyclic compound, transcription regulatory region DNA binding, repressing transcription factor binding, ion channel binding |
| InterPro ID |
IPR000225, IPR013284 |
| Ensembl Family |
ENSFM00250000001012 |
| InterPro Term |
Armadillo, Beta-catenin |
| Ensembl Family Description |
CATENIN |
| Ensembl Protein ID |
ENSP00000401599, ENSP00000412219, ENSP00000409302, ENSP00000385604, ENSP00000344456, ENSP00000411226, ENSP00000387455, ENSP00000379488, ENSP00000379486, ENSP00000400508 |
| RefSeq ID |
NM_001098210, NM_001098209, NP_001895, NM_001904, NP_001091679, NP_001091680 |
| HGNC Symbol |
CTNNB1 |
| Gene-Disease Assocation |
OVARIAN CANCER, SALIVARY GLAND ADENOMA, PLEOMORPHIC, HEPATOCELLULAR CARCINOMA, PILOMATRIXOMA, COLORECTAL CANCER; CRC, MEDULLOBLASTOMA; MDB |
| UniProt Accession |
P35222, C9IZ65, B2ZRG2, B2ZRE2, B4DGU4, E7EMJ5, E7EV28, E9PDF9 |
| Description |
catenin (cadherin-associated protein), beta 1, 88kDa [Source:HGNC Symbol;Acc:2514] |
| EMBL-Bank ID |
BC058926, X87838, EU681277, EU681190, AY463360, CH471055, AK294778, AY081165, Z19054, AC104307, AK289932, AB062292, AF130085 |
| UniGene ID |
Hs.603944, Hs.476018 |
| Entrez Gene ID |
1499 |
| Ensembl Gene ID |
ENSG00000168036 |
| Ensembl Transcript ID |
ENST00000431914, ENST00000485265, ENST00000396185, ENST00000396183, ENST00000482042, ENST00000426215, ENST00000471014, ENST00000465552, ENST00000349496, ENST00000488914, ENST00000433400, ENST00000450969, ENST00000405570, ENST00000453024, ENST00000441708 |
| Design Element |
223679_at, ENST00000431914, 1554411_at, ENST00000485265, 40777_at, ENST00000450969, X87838_at, g4503130_3p_at, ENST00000396185, ENST00000465552, ENST00000471014, ENST00000482042, ENST00000396183, g11493474_RC_3p_at, ENST00000488914, ENST00000433400, ENST00000405570, Hs2.171271.2.S1_3p_s_at, ENST00000349496, ENST00000441708, 54930_at, 201533_at, ENST00000426215, ENST00000453024 |
| Search EB-eye |
ENSG00000168036
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