PLK1
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Homo sapiens |
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PLK1 is differentially expressed in 261 experiments: 81 organism parts: bone marrow, testis, ... (79 more);, 185 disease states: normal, adenocarcinoma, ... (183 more);, 84 cell types 290 cell lines 34 compound treatments and 75 other conditions. |
| Synonyms |
PLK |
| Orthologs |
ENSCING00000003627
(Ciona intestinalis)
Plk1
(Mus musculus)
CDC5
(Saccharomyces cerevisiae)
Plk1
(Rattus norvegicus)
plk1
(Danio rerio)
PLK1
(Bos taurus)
PLK1
(Gallus gallus)
polo
(Drosophila melanogaster)
plk1
(Xenopus laevis)
PLK1
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR000959, IPR020635 |
| Gene Ontology Term |
cytosol, spindle midzone, spindle pole, response to antibiotic, M phase of mitotic cell cycle, protein binding, positive regulation of peptidyl-threonine phosphorylation, cytoskeleton, kinetochore, cytoplasm, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, cell proliferation, peptidyl-serine phosphorylation, protein ubiquitination, mitotic cell cycle, anaphase-promoting complex binding, protein tyrosine kinase activity, spindle microtubule, condensed chromosome kinetochore, regulation of mitotic cell cycle, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, mitotic prometaphase, ATP binding, midbody, centrosome, regulation of cell cycle, protein kinase binding, nucleus, cytokinesis, G2/M transition of mitotic cell cycle, mitosis, nucleotide binding, protein serine/threonine kinase activity, chromosome, nucleoplasm, G2/M transition DNA damage checkpoint, negative regulation of cyclin-dependent protein kinase activity, protein kinase activity, positive regulation of proteolysis, polo kinase kinase activity, regulation of protein binding, mitotic metaphase/anaphase transition, protein destabilization, polar body extrusion after meiotic divisions, positive regulation of ubiquitin-protein ligase activity, protein phosphorylation, protein localization to chromatin, condensed nuclear chromosome outer kinetochore, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, regulation of mitotic anaphase, regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitotic prophase |
| Gene Ontology ID |
GO:0008283, GO:0016567, GO:0007067, GO:0007346, GO:0051233, GO:0030496, GO:0000086, GO:0000087, GO:0004713, GO:0042801, GO:0005524, GO:0005515, GO:0005737, GO:0005694, GO:0005634, GO:0005654, GO:0005876, GO:0005856, GO:0005829, GO:0005813, GO:0004672, GO:0004674, GO:0032436, GO:0019901, GO:0000777, GO:0000776, GO:0000922, GO:0000910, GO:0006468, GO:0031145, GO:0045736, GO:0000166, GO:0018105, GO:0051726, GO:0000278, GO:0000236, GO:0045862, GO:0046677, GO:0031572, GO:0010800, GO:0010997, GO:0007091, GO:0051443, GO:0040038, GO:0000942, GO:0031648, GO:0043393, GO:0071168, GO:0051437, GO:0090007, GO:0051439, GO:0000088 |
| InterPro Term |
POLO_box_duplicated_dom, Prot_kinase_cat_dom, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family |
ENSFM00260000050409 |
| Ensembl Family Description |
SERINE/THREONINE KINASE PLK4 EC_2.7.11.21 POLO KINASE 4 PLK 4 SERINE/THREONINE KINASE SAK |
| Ensembl Protein ID |
ENSP00000391649, ENSP00000331713, ENSP00000300093 |
| RefSeq ID |
NM_005030, NP_005021 |
| EMBL-Bank ID |
L19559, U01038, AB084459, BC014846, X90725, BC002369, AK303263, U78073, CH471145, AC008870, BC003002, X73458, X75932 |
| UniProt Accession |
Q58A51, P53350, B4E083, D3DWF3 |
| Ensembl Gene ID |
ENSG00000166851 |
| HGNC Symbol |
PLK1 |
| UniGene ID |
Hs.592049, Hs.727003 |
| Description |
polo-like kinase 1 [Source:HGNC Symbol;Acc:9077] |
| Entrez Gene ID |
5347 |
| Ensembl Transcript ID |
ENST00000300093, ENST00000425844, ENST00000330792 |
| Design Element |
U01038_at, 37228_at, 202240_at, ENST00000425844, ENST00000300093, g4826915_3p_at, gnf1h09403_s_at, ENST00000330792, gnf1h01118_at |
| Search EB-eye |
ENSG00000166851
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