RET
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Homo sapiens |
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RET is differentially expressed in 255 experiments: 113 organism parts: lung, prostate, ... (111 more);, 137 disease states: normal, colorectal adenocarcinoma, ... (135 more);, 71 cell types 256 cell lines 31 compound treatments and 71 other conditions. |
| Synonyms |
HSCR1, CDHR16, PTC, MTC1, MEN2A, MEN2B, RET51, CDHF12 |
| Orthologs |
Ret
(Mus musculus)
F1NL49_CHICK
(Gallus gallus)
ret1
(Danio rerio)
F1MAG5_RAT
(Rattus norvegicus)
RET
(Bos taurus)
Ret
(Drosophila melanogaster)
ret
(Xenopus laevis)
A2SXS8_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR020635, IPR002126, IPR016249 |
| Gene Ontology ID |
GO:0016020, GO:0016021, GO:0007156, GO:0007169, GO:0007165, GO:0007399, GO:0007497, GO:0004713, GO:0004714, GO:0005524, GO:0005509, GO:0005515, GO:0004872, GO:0004672, GO:0004674, GO:0006468, GO:0000165, GO:0000166, GO:0001838, GO:0045893, GO:0042551, GO:0048484, GO:0001755, GO:0001657, GO:0071300, GO:0010976, GO:0072300 |
| Gene Ontology Term |
protein binding, membrane, homophilic cell adhesion, MAPKKK cascade, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway, posterior midgut development, ATP binding, receptor activity, nucleotide binding, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, nervous system development, integral to membrane, signal transduction, positive regulation of transcription, DNA-dependent, calcium ion binding, protein kinase activity, embryonic epithelial tube formation, cellular response to retinoic acid, positive regulation of neuron projection development, neuron maturation, neural crest cell migration, ureteric bud development, enteric nervous system development, protein phosphorylation, positive regulation of metanephric glomerulus development |
| InterPro Term |
Prot_kinase_cat_dom, Cadherin, Tyr_kinase_Ret_rcpt, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| UniProt Accession |
P07949, Q9UQV8, Q9UM90, Q8IZR8, Q9UE13, Q8NFE8, B4DGX8, Q9BTX6, C9JYL6, F5CNE9, F8TLS5, F8TLW0 |
| RefSeq ID |
NP_065681, NM_020975, NM_020630, NP_066124 |
| HGNC Symbol |
RET |
| UniGene ID |
Hs.350321, Hs.625268 |
| EMBL-Bank ID |
AF520979, AF520975, Y12528, AF520983, X15786, AJ297349, Y15743, X15262, BC004257, X12949, CH471160, S80097, AK294827, M31213, BC003072, M16029, AC010864, AK291807, JF276429, JF742661, JF273638 |
| Ensembl Protein ID |
ENSP00000344798, ENSP00000419080, ENSP00000347942, ENSP00000445963 |
| Gene-Disease Assocation |
RENAL ADYSPLASIA, THYROID CARCINOMA, PAPILLARY, PHEOCHROMOCYTOMA, MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIB; MEN2B, COLORECTAL CANCER; CRC, CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL; CCHS, THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC, MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A, HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1; HSCR1 |
| Description |
ret proto-oncogene [Source:HGNC Symbol;Acc:9967] |
| Entrez Gene ID |
5979 |
| Ensembl Gene ID |
ENSG00000165731 |
| Ensembl Family |
ENSFM00640001103095 |
| Ensembl Family Description |
PROTO ONCOGENE TYROSINE KINASE RECEPTOR RET PRECURSOR EC_2.7.10.1 PROTO ONCOGENE C RET |
| Ensembl Transcript ID |
ENST00000355710, ENST00000340058, ENST00000535749, ENST00000498820, ENST00000479913 |
| Design Element |
Hs.241572.1.S1_3p_s_at, g13279040_3p_s_at, M57464_s_at, 160028_s_at, 1889_s_at, 1822_at, 1745_at, ENST00000479913, 91896_at, ENST00000498820, ENST00000535749, 211421_s_at, g13279040_3p_a_at, 1823_g_at, 205879_x_at, ENST00000355710, g190699_3p_a_at, ENST00000340058, 215771_x_at |
| Search EB-eye |
ENSG00000165731
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