OTX2
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Homo sapiens |
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OTX2 is differentially expressed in 84 experiments: 37 organism parts: cerebellum, brain, ... (35 more);, 42 disease states: normal, AF, ... (40 more);, 41 cell types 55 cell lines 4 compound treatments and 36 other conditions. |
| Orthologs |
Otx2
(Mus musculus)
otx2
(Danio rerio)
Q4H303_CIOIN
(Ciona intestinalis)
oc
(Drosophila melanogaster)
E1BNP1_BOVIN
(Bos taurus)
OTX2_RAT
(Rattus norvegicus)
otx2
(Xenopus laevis)
OTX2
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008190, GO:0009887, GO:0009953, GO:0009952, GO:0003700, GO:0007275, GO:0008589, GO:0007411, GO:0007417, GO:0007492, GO:0030426, GO:0005515, GO:0005737, GO:0005634, GO:0006461, GO:0006355, GO:0006357, GO:0006351, GO:0001708, GO:0046982, GO:0043234, GO:0045944, GO:0043565, GO:0045893, GO:0030154, GO:0030182, GO:0045165, GO:0048856, GO:0042472, GO:0048663, GO:0042706, GO:0030901, GO:0030900, GO:0040036, GO:0040019, GO:0032525, GO:0090009, GO:2000543, GO:0001077 |
| Gene Ontology Term |
neuron differentiation, protein binding, eukaryotic initiation factor 4E binding, regulation of transcription, DNA-dependent, cytoplasm, protein complex, transcription, DNA-dependent, protein complex assembly, cell fate specification, cell differentiation, sequence-specific DNA binding, axon guidance, endoderm development, positive regulation of transcription from RNA polymerase II promoter, multicellular organismal development, nucleus, protein heterodimerization activity, growth cone, cell fate commitment, regulation of smoothened signaling pathway, regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, organ morphogenesis, central nervous system development, dorsal/ventral pattern formation, positive regulation of embryonic development, somite rostral/caudal axis specification, forebrain development, eye photoreceptor cell fate commitment, anatomical structure development, regulation of fibroblast growth factor receptor signaling pathway, inner ear morphogenesis, neuron fate commitment, primitive streak formation, midbrain development, sequence-specific DNA binding transcription factor activity, positive regulation of gastrulation, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, anterior/posterior pattern specification |
| InterPro ID |
IPR001356, IPR013851, IPR003022, IPR003025 |
| InterPro Term |
Homeobox, Otx_TF, Otx_TF_C, Otx2_TF |
| Ensembl Family Description |
HOMEOBOX |
| Ensembl Family |
ENSFM00500000269876 |
| RefSeq ID |
NP_758840, NP_068374, NM_172337, NM_021728 |
| EMBL-Bank ID |
AF298117, AF093138, AB037505, CH471061, BC032579, AK314271, AB593057, AB593056, AB593058 |
| HGNC Symbol |
OTX2 |
| UniGene ID |
Hs.709117, Hs.288655 |
| Ensembl Gene ID |
ENSG00000165588 |
| Description |
orthodenticle homeobox 2 [Source:HGNC Symbol;Acc:8522] |
| Ensembl Protein ID |
ENSP00000343819, ENSP00000386185, ENSP00000452336, ENSP00000450468, ENSP00000451272, ENSP00000451357 |
| UniProt Accession |
P32243, F1T0D1, F1T0D0, F1T0C9 |
| Entrez Gene ID |
5015 |
| Ensembl Transcript ID |
ENST00000408990, ENST00000554559, ENST00000554788, ENST00000554845, ENST00000339475, ENST00000555006, ENST00000555804 |
| Gene-Disease Assocation |
PITUITARY HORMONE DEFICIENCY, COMBINED, 6; CPHD6, MICROPHTHALMIA, SYNDROMIC 5; MCOPS5 |
| Design Element |
Hs.288655.0.S1_3p_at, ENST00000555006, 231731_at, ENST00000554788, Hs.30837.0.A1_3p_at, 53326_at, ENST00000555804, 242128_at, ENST00000408990, ENST00000554845, ENST00000554559, gnf1h00384_at, ENST00000339475 |
| Search EB-eye |
ENSG00000165588
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