WRN
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Homo sapiens |
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WRN is differentially expressed in 206 experiments: 103 organism parts: bone marrow, mammary gland, ... (101 more);, 150 disease states: normal, chronic myelogenous leukemia, ... (148 more);, 59 cell types 261 cell lines 24 compound treatments and 57 other conditions. |
| Synonyms |
RECQ3, RECQL2 |
| Orthologs |
SGS1
(Saccharomyces cerevisiae)
ENSCING00000008935
(Ciona intestinalis)
WRN
(Gallus gallus)
wrn
(Danio rerio)
WRN
(Bos taurus)
Wrn
(Mus musculus)
RecQ4
(Drosophila melanogaster)
F1LTH9_RAT
(Rattus norvegicus)
wrn
(Xenopus laevis)
Q5SBI9_CANFA
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0003676, GO:0003677, GO:0003678, GO:0008026, GO:0009378, GO:0010259, GO:0008408, GO:0007568, GO:0004386, GO:0004003, GO:0016887, GO:0042803, GO:0005622, GO:0005524, GO:0005515, GO:0005730, GO:0005634, GO:0005654, GO:0004527, GO:0005813, GO:0006979, GO:0006974, GO:0042981, GO:0000723, GO:0000731, GO:0043140, GO:0043138, GO:0000166, GO:0006310, GO:0000287, GO:0006284, GO:0006281, GO:0006260, GO:0006259, GO:0006139, GO:0044237, GO:0000403, GO:0030145, GO:0010225, GO:0051345, GO:0007569, GO:0001302, GO:0032403, GO:0031297, GO:0040009, GO:0006200, GO:0051880, GO:0000405, GO:0009267, GO:0032066, GO:0032389 |
| Gene Ontology Term |
telomere maintenance, response to oxidative stress, DNA binding, 3'-5' DNA helicase activity, protein binding, DNA repair, cellular metabolic process, intracellular, 3'-5' exonuclease activity, ATPase activity, ATP-dependent helicase activity, nucleic acid binding, multicellular organismal aging, ATP-dependent 3'-5' DNA helicase activity, four-way junction helicase activity, ATP binding, magnesium ion binding, centrosome, Y-form DNA binding, nucleus, ATP-dependent DNA helicase activity, manganese ion binding, aging, DNA recombination, nucleotide binding, DNA helicase activity, protein homodimerization activity, nucleoplasm, base-excision repair, response to DNA damage stimulus, DNA synthesis involved in DNA repair, exonuclease activity, DNA replication, nucleolus, helicase activity, DNA metabolic process, regulation of apoptosis, G-quadruplex DNA binding, cell aging, replication fork processing, ATP catabolic process, MutLalpha complex, response to UV-C, regulation of growth rate, positive regulation of hydrolase activity, bubble DNA binding, nucleolus to nucleoplasm transport, protein complex binding, cellular response to starvation, replicative cell aging, nucleobase-containing compound metabolic process |
| InterPro ID |
IPR001650, IPR002562, IPR011545, IPR014001, IPR002121, IPR018982, IPR004589 |
| InterPro Term |
Helicase/RNaseD_C, DNA/RNA_helicase_DEAD/DEAH_N, RQC_domain, Helicase_C, DNA_helicase_ATP-dep_RecQ, DEAD-like_helicase, 3'-5'_exonuclease |
| Ensembl Family |
ENSFM00590000915523 |
| Ensembl Family Description |
WERNER SYNDROME ATP DEPENDENT HELICASE EC_3.6.4.12 EXONUCLEASE WRN EC_3.1.-.- |
| Description |
Werner syndrome, RecQ helicase-like [Source:HGNC Symbol;Acc:12791] |
| EMBL-Bank ID |
AF181896, AF181897, AF091214, L76937, AY818673, AY442327, AC084736 |
| UniGene ID |
Hs.631240, Hs.632050 |
| HGNC Symbol |
WRN |
| Ensembl Protein ID |
ENSP00000298139 |
| Ensembl Gene ID |
ENSG00000165392 |
| UniProt Accession |
Q14191 |
| RefSeq ID |
NP_000544, NM_000553 |
| Entrez Gene ID |
7486 |
| Gene-Disease Assocation |
WERNER SYNDROME; WRN, COLORECTAL CANCER; CRC |
| Ensembl Transcript ID |
ENST00000521620, ENST00000298139, ENST00000520169 |
| Design Element |
205667_at, 38136_at, ENST00000521620, ENST00000520169, g5739523_3p_at, L76937_rna1_at, ENST00000298139 |
| Search EB-eye |
ENSG00000165392
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