SYK
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Homo sapiens |
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SYK is differentially expressed in 294 experiments: 131 organism parts: thymus, liver, ... (129 more);, 250 disease states: normal, acute myeloid leukemia, ... (248 more);, 129 cell types 485 cell lines 40 compound treatments and 77 other conditions. |
| Orthologs |
SYK
(Gallus gallus)
syk
(Danio rerio)
Sykb
(Mus musculus)
Q32PK0_BOVIN
(Bos taurus)
hop
(Drosophila melanogaster)
Syk
(Rattus norvegicus)
syk
(Xenopus laevis)
Q6JDG6_CANFA
(Canis familiaris)
(Compare orthologs)
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| InterPro ID |
IPR002290, IPR001245, IPR017442, IPR000719, IPR000980, IPR020635, IPR012234 |
| Gene Ontology ID |
GO:0009887, GO:0008283, GO:0007166, GO:0007257, GO:0007229, GO:0007596, GO:0004713, GO:0004715, GO:0005622, GO:0005524, GO:0005515, GO:0005737, GO:0005886, GO:0005829, GO:0004672, GO:0004674, GO:0005178, GO:0050776, GO:0019904, GO:0019901, GO:0006468, GO:0006461, GO:0000166, GO:0000187, GO:0019370, GO:0018108, GO:0046777, GO:0007159, GO:0007167, GO:0030593, GO:0004716, GO:0050731, GO:0050850, GO:0019815, GO:0050853, GO:0042101, GO:0043366, GO:0043306, GO:0044419, GO:0045579, GO:0045588, GO:0001820, GO:0046638, GO:0046641, GO:0030168, GO:0045425, GO:0045401, GO:0035556 |
| Gene Ontology Term |
cytosol, plasma membrane, leukotriene biosynthetic process, protein binding, cytoplasm, cell proliferation, intracellular, peptidyl-tyrosine phosphorylation, protein tyrosine kinase activity, blood coagulation, protein domain specific binding, protein complex assembly, integrin-mediated signaling pathway, activation of MAPK activity, ATP binding, activation of JUN kinase activity, cell surface receptor linked signaling pathway, protein kinase binding, nucleotide binding, protein serine/threonine kinase activity, integrin binding, non-membrane spanning protein tyrosine kinase activity, organ morphogenesis, protein kinase activity, regulation of immune response, positive regulation of alpha-beta T cell proliferation, positive regulation of B cell differentiation, B cell receptor complex, receptor signaling protein tyrosine kinase activity, positive regulation of interleukin-3 biosynthetic process, B cell receptor signaling pathway, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, positive regulation of alpha-beta T cell differentiation, positive regulation of gamma-delta T cell differentiation, positive regulation of calcium-mediated signaling, interspecies interaction between organisms, beta selection, serotonin secretion, positive regulation of mast cell degranulation, leukocyte cell-cell adhesion, enzyme linked receptor protein signaling pathway, neutrophil chemotaxis, T cell receptor complex, platelet activation, protein autophosphorylation, protein phosphorylation, intracellular signal transduction |
| InterPro Term |
SH2, Prot_kinase_cat_dom, Tyr_kinase_non-rcpt_SYK/ZAP70, Ser/Thr_kinase_dom, Tyr_kinase_cat_dom, Ser-Thr/Tyr_kinase, Se/Thr_kinase-like_dom |
| Ensembl Family Description |
TYROSINE KINASE EC_2.7.10.2 TYROSINE KINASE |
| Ensembl Family |
ENSFM00260000050604 |
| EMBL-Bank ID |
L28824, BC001645, BC002962, Z29630, X73568, BC011399, AL354862 |
| UniProt Accession |
P43405 |
| RefSeq ID |
NM_001174168, NM_001174167, NM_003177, NP_001128524, NP_003168, NP_001167638, NP_001167639, NM_001135052 |
| HGNC Symbol |
SYK |
| Description |
spleen tyrosine kinase [Source:HGNC Symbol;Acc:11491] |
| Entrez Gene ID |
6850 |
| Ensembl Protein ID |
ENSP00000364899, ENSP00000364898, ENSP00000364907, ENSP00000364904 |
| Ensembl Gene ID |
ENSG00000165025 |
| UniGene ID |
Hs.371720 |
| Ensembl Transcript ID |
ENST00000476708, ENST00000375746, ENST00000375747, ENST00000375754, ENST00000375751 |
| Design Element |
1630_s_at, ENST00000375751, ENST00000375746, 36885_at, Hs.74101.2.S1_3p_a_at, Hs.74101.1.S2_3p_a_at, g4507328_3p_a_at, ENST00000375747, ENST00000375754, 209269_s_at, 226068_at, 548_s_at, 55564_at, 207540_s_at, ENST00000476708, S80267_s_at, Hs.74101.2.S1_3p_at |
| Search EB-eye |
ENSG00000165025
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