SHH
close
Please copy/paste those URLs into your code to get same results in machine-readable formats:
|
Homo sapiens |
|
SHH is differentially expressed in 156 experiments: 79 organism parts: bone marrow, liver, ... (77 more);, 116 disease states: normal, glioblastoma, ... (114 more);, 38 cell types 181 cell lines 19 compound treatments and 63 other conditions. |
| Synonyms |
SMMCI, HPE3, MCOPCB5, TPT, HHG1, TPTPS, HLP3 |
| Orthologs |
shhb
(Danio rerio)
Shh
(Rattus norvegicus)
SHH
(Bos taurus)
Shh
(Mus musculus)
Q8MY57_CIOIN
(Ciona intestinalis)
shha
(Danio rerio)
SHH
(Gallus gallus)
hh
(Drosophila melanogaster)
shh
(Xenopus laevis)
B8PZT0_CANFA
(Canis familiaris)
(Compare orthologs)
|
| Gene Ontology Term |
angiogenesis, hindgut morphogenesis, establishment of cell polarity, striated muscle tissue development, pattern specification process, plasma membrane, embryo development, androgen metabolic process, positive regulation of hh target transcription factor activity, neuroblast proliferation, endoplasmic reticulum, protein binding, apoptosis, regulation of transcription, DNA-dependent, digestive tract morphogenesis, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, cell proliferation, regulation of cell proliferation, extracellular space, trachea morphogenesis, positive regulation of cell proliferation, positive regulation of gene expression, developmental growth, intein-mediated protein splicing, peptidase activity, negative regulation of apoptosis, Golgi apparatus, male genitalia development, embryonic foregut morphogenesis, embryonic morphogenesis, extracellular region, cell-cell signaling, blood coagulation, membrane raft, response to hypoxia, membrane fraction, cell fate specification, smoothened signaling pathway, ventral midline development, negative regulation of Wnt receptor signaling pathway, signal transducer activity, positive regulation of photoreceptor cell differentiation, positive regulation of neuroblast proliferation, cell communication, axon guidance, positive regulation of transcription from RNA polymerase II promoter, multicellular organismal development, nucleus, response to axon injury, heart development, negative regulation of cell migration, regulation of gene expression, positive regulation of smoothened signaling pathway, male genitalia morphogenesis, canonical Wnt receptor signaling pathway, patched binding, cell death, cell fate commitment, regulation of proteolysis, proteolysis, stem cell development, negative regulation of transcription from RNA polymerase II promoter, cell surface, negative regulation of cell differentiation, extracellular matrix, positive regulation of Wnt receptor signaling pathway, response to ethanol, determination of left/right symmetry, negative regulation of gene expression, ectoderm development, signal transduction, positive regulation of transcription, DNA-dependent, calcium ion binding, central nervous system development, zinc ion binding, regulation of apoptosis, dorsal/ventral pattern formation, endocytosis, positive regulation of oligodendrocyte progenitor proliferation, positive regulation of mesenchymal cell proliferation, embryonic organ development, right lung development, regulation of epithelial cell differentiation, neural tube formation, negative regulation of alpha-beta T cell differentiation, transport vesicle, prostate gland development, striated muscle cell differentiation, bud outgrowth involved in lung branching, lung lobe morphogenesis, oligodendrocyte differentiation, epithelial-mesenchymal signaling involved in prostate gland development, positive regulation of neuron differentiation, response to organic nitrogen, epithelial tube branching involved in lung morphogenesis, positive regulation of striated muscle cell differentiation, trachea development, regulation of epithelial cell proliferation involved in prostate gland development, mesenchymal cell proliferation, hair follicle development, regulation of prostatic bud formation, positive regulation of skeletal muscle tissue development, kidney development, branching involved in ureteric bud morphogenesis, hindbrain development, Bergmann glial cell differentiation, embryonic hindlimb morphogenesis, mesenchymal smoothened signaling pathway involved in prostate gland development, negative thymic T cell selection, prostate epithelial cord elongation, limb development, inner ear development, primary prostatic bud elongation, forebrain development, branching involved in salivary gland morphogenesis, myotube differentiation, sclerotome development, embryonic forelimb morphogenesis, lung-associated mesenchyme development, multicellular structure septum development, positive regulation of protein import into nucleus, epithelial-mesenchymal cell signaling, dorsal/ventral neural tube patterning, embryonic skeletal system development, hair follicle morphogenesis, ventral spinal cord interneuron specification, anatomical structure development, anatomical structure formation involved in morphogenesis, cellular response to lithium ion, branching morphogenesis of a tube, pancreas development, vasculogenesis, lymphoid progenitor cell differentiation, branching involved in prostate gland morphogenesis, positive regulation of alpha-beta T cell differentiation, myoblast differentiation, odontogenesis, metanephros development, limb bud formation, vasculature development, neural crest cell migration, response to retinoic acid, glycosaminoglycan binding, intermediate filament organization, positive regulation of oligodendrocyte differentiation, embryonic digit morphogenesis, embryonic digestive tract morphogenesis, left lung development, osteoblast development, artery development, positive regulation of cell differentiation, skin development, laminin-1 binding, lung morphogenesis, glycoprotein binding, digestive tract mesoderm development, response to estradiol stimulus, epithelial cell proliferation involved in salivary gland morphogenesis, lung development, tongue morphogenesis, positive regulation of epithelial cell proliferation involved in prostate gland development, camera-type eye development, patterning of blood vessels, neuron fate commitment, palate development, mesenchymal cell proliferation involved in lung development, telencephalon regionalization, oligodendrocyte development, respiratory tube development, thymus development, odontogenesis of dentine-containing tooth, salivary gland cavitation, thyroid gland development, embryonic limb morphogenesis, midbrain development, renal system development, negative regulation of canonical Wnt receptor signaling pathway, spinal cord dorsal/ventral patterning, heart looping, positive regulation of skeletal muscle cell proliferation, positive thymic T cell selection, formation of anatomical boundary, lung epithelium development, regulation of mesenchymal cell proliferation involved in prostate gland development, positive regulation of penile erection, negative regulation of T cell proliferation, cell development, negative regulation of protein catabolic process, organ formation, somite development, determination of left/right asymmetry in lateral mesoderm, T cell differentiation in thymus, protein localization to nucleus, CD4-positive or CD8-positive, alpha-beta T cell lineage commitment, positive regulation of immature T cell proliferation in thymus, positive regulation of kidney smooth muscle cell differentiation, negative regulation of ureter smooth muscle cell differentiation, negative regulation of transcription elongation from RNA polymerase II promoter, positive regulation of mesenchymal cell proliferation involved in ureter development, positive regulation of ureter smooth muscle cell differentiation, smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation, positive regulation of cerebellar granule cell precursor proliferation, metanephric mesenchymal cell proliferation involved in metanephros development, negative regulation of kidney smooth muscle cell differentiation, positive regulation of T cell differentiation in thymus, anterior/posterior pattern specification |
| Gene Ontology ID |
GO:0008233, GO:0008219, GO:0008209, GO:0060439, GO:0010629, GO:0010628, GO:0009953, GO:0009952, GO:0008283, GO:0008284, GO:0009986, GO:0008270, GO:0010468, GO:0060070, GO:0016539, GO:0007154, GO:0007165, GO:0007267, GO:0007275, GO:0007224, GO:0007228, GO:0009790, GO:0007398, GO:0007368, GO:0007389, GO:0007442, GO:0007411, GO:0007418, GO:0007417, GO:0048864, GO:0048808, GO:0007405, GO:0007596, GO:0007507, GO:0030539, GO:0048617, GO:0048678, GO:0048589, GO:0048598, GO:0048546, GO:0005624, GO:0005615, GO:0005509, GO:0005515, GO:0005576, GO:0004871, GO:0006915, GO:0005634, GO:0006897, GO:0005886, GO:0002052, GO:0005783, GO:0005794, GO:0042981, GO:0005113, GO:0032435, GO:0043066, GO:0006508, GO:0031012, GO:0000122, GO:0014706, GO:0042127, GO:0006355, GO:0001708, GO:0045596, GO:0045944, GO:0046534, GO:0001525, GO:0045880, GO:0045893, GO:0001666, GO:0030162, GO:0030177, GO:0030178, GO:0030010, GO:0045165, GO:0045121, GO:0045471, GO:0030336, GO:0060459, GO:0060463, GO:0060484, GO:0060406, GO:0060428, GO:0060425, GO:0060441, GO:0060445, GO:0060442, GO:0060438, GO:0060458, GO:0060447, GO:0072001, GO:0010463, GO:0060684, GO:0060685, GO:0060662, GO:0060664, GO:0060523, GO:0060516, GO:0060020, GO:0060021, GO:0010243, GO:0072136, GO:0060174, GO:0060173, GO:0048859, GO:0048856, GO:0048839, GO:0048709, GO:0048706, GO:0048714, GO:0042307, GO:0048754, GO:0007502, GO:0051146, GO:0042476, GO:0042475, GO:0051155, GO:0048646, GO:0048643, GO:0048645, GO:0048663, GO:0048568, GO:0048538, GO:0048557, GO:0048468, GO:0005539, GO:0002320, GO:0042733, GO:0061056, GO:0061053, GO:0014003, GO:0030902, GO:0030901, GO:0030900, GO:0002053, GO:0002076, GO:0030878, GO:0030850, GO:0030856, GO:0032526, GO:0090090, GO:0080125, GO:0001942, GO:0001944, GO:0001947, GO:0001948, GO:0031016, GO:0031069, GO:0043010, GO:0001755, GO:0042130, GO:0042177, GO:0014858, GO:0045666, GO:0043237, GO:0045597, GO:0001822, GO:0001841, GO:0046639, GO:0046638, GO:0014902, GO:0001570, GO:0001569, GO:0043588, GO:0043587, GO:0001658, GO:0001656, GO:0021940, GO:0021938, GO:0030133, GO:0021904, GO:0021978, GO:0045109, GO:0045445, GO:0071285, GO:0070447, GO:0060738, GO:0060783, GO:0060782, GO:0060768, GO:0060769, GO:0030324, GO:0030326, GO:0030323, GO:0060916, GO:0060840, GO:0021521, GO:0021513, GO:0034504, GO:0045060, GO:0035115, GO:0035116, GO:0045059, GO:0033077, GO:0033089, GO:0033092, GO:0032355, GO:0034244, GO:0003140, GO:2000729, GO:0043369, GO:2000062, GO:2000063, GO:2000358, GO:2000357 |
| InterPro ID |
IPR001657, IPR000320, IPR001767, IPR006141, IPR003586, IPR003587 |
| InterPro Term |
Hedgehog_hint_N, Hedgehog_hint_C, Peptidase_C46, Peptidase_C46_hint, Intein_splice_site, Hedgehog_signaling_dom |
| Ensembl Family Description |
HEDGEHOG HEDGEHOG N PRODUCT; HEDGEHOG C PRODUCT] |
| Ensembl Family |
ENSFM00250000000992 |
| Description |
sonic hedgehog [Source:HGNC Symbol;Acc:10848] |
| UniProt Accession |
Q15465, C9JC48, D9ZGF9, F8WEH4, F8WB84 |
| UniGene ID |
Hs.606487, Hs.164537, Hs.619304, Hs.731051 |
| HGNC Symbol |
SHH |
| EMBL-Bank ID |
AY422195, L38518, AC078834, CH471149, AC002484, CH236954, HM015597 |
| Ensembl Protein ID |
ENSP00000297261, ENSP00000396621, ENSP00000413871, ENSP00000410546 |
| Entrez Gene ID |
6469 |
| Ensembl Gene ID |
ENSG00000164690 |
| Gene-Disease Assocation |
SCHIZENCEPHALY, COLOBOMA, OCULAR, MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 5; MCOPCB5, SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR; SMMCI, HOLOPROSENCEPHALY 3; HPE3, POLYDACTYLY, PREAXIAL II; PPD2 |
| RefSeq ID |
NP_000184, NM_000193 |
| Ensembl Transcript ID |
ENST00000430104, ENST00000441114, ENST00000435425, ENST00000472308, ENST00000297261 |
| Design Element |
ENST00000472308, ENST00000441114, ENST00000435425, g4506938_3p_at, 70121_at, ENST00000430104, 31724_at, ENST00000297261, 236263_at, Hs.164537.0.A1_3p_at, 207586_at, 59360_at |
| Search EB-eye |
ENSG00000164690
|
 Show more
properties
|
|
