ERCC3
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Homo sapiens |
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ERCC3 is differentially expressed in 216 experiments: 89 organism parts: cerebellum, testis, ... (87 more);, 163 disease states: normal, multiple myeloma, ... (161 more);, 62 cell types 230 cell lines 24 compound treatments and 61 other conditions. |
| Synonyms |
TFIIH, XPB, RAD25, BTF2, GTF2H |
| Orthologs |
ERCC3
(Gallus gallus)
ERCC3_BOVIN
(Bos taurus)
Ercc3
(Rattus norvegicus)
ercc3
(Ciona intestinalis)
Ercc3
(Mus musculus)
SSL2
(Saccharomyces cerevisiae)
ercc3
(Danio rerio)
hay
(Drosophila melanogaster)
NP_001123812.1
(Xenopus laevis)
ERCC3
(Canis familiaris)
(Compare orthologs)
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| Gene Ontology ID |
GO:0008134, GO:0003684, GO:0003676, GO:0003677, GO:0008353, GO:0008094, GO:0008022, GO:0008104, GO:0009411, GO:0042277, GO:0004386, GO:0004003, GO:0016887, GO:0016787, GO:0000075, GO:0005524, GO:0005525, GO:0005515, GO:0047485, GO:0006917, GO:0005634, GO:0005654, GO:0006979, GO:0004672, GO:0043138, GO:0006468, GO:0000166, GO:0006360, GO:0006355, GO:0006370, GO:0006366, GO:0006367, GO:0006368, GO:0006289, GO:0006281, GO:0006265, GO:0045944, GO:0001666, GO:0016032, GO:0010467, GO:0009650, GO:0005675, GO:0000717, GO:0032564, GO:0006361, GO:0006200, GO:0044419, GO:0006283, GO:0050434, GO:0000441, GO:0035315, GO:0033683, GO:0006362, GO:0006363, GO:0000718 |
| Gene Ontology Term |
response to UV, response to oxidative stress, DNA binding, protein localization, nucleotide-excision repair, 3'-5' DNA helicase activity, protein binding, DNA repair, regulation of transcription, DNA-dependent, damaged DNA binding, ATPase activity, protein N-terminus binding, nucleic acid binding, response to hypoxia, mRNA capping, transcription from RNA polymerase II promoter, transcription factor binding, GTP binding, ATP binding, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, RNA polymerase II carboxy-terminal domain kinase activity, DNA-dependent ATPase activity, peptide binding, nucleus, ATP-dependent DNA helicase activity, nucleotide binding, hydrolase activity, transcription initiation from RNA polymerase II promoter, protein C-terminus binding, nucleoplasm, cell cycle checkpoint, DNA topological change, protein kinase activity, transcription from RNA polymerase I promoter, helicase activity, nucleotide-excision repair, DNA incision, viral reproduction, transcription-coupled nucleotide-excision repair, ATP catabolic process, nucleotide-excision repair, DNA duplex unwinding, holo TFIIH complex, gene expression, UV protection, dATP binding, hair cell differentiation, interspecies interaction between organisms, transcription initiation from RNA polymerase I promoter, positive regulation of viral transcription, SSL2-core TFIIH complex, protein phosphorylation, termination of RNA polymerase I transcription, nucleotide-excision repair, DNA damage removal, transcription elongation from RNA polymerase II promoter, transcription elongation from RNA polymerase I promoter |
| InterPro Term |
XPGB_DNA_repair, Helicase_C, DEAD-like_helicase, Helicase/UvrB_dom |
| InterPro ID |
IPR001650, IPR001161, IPR006935, IPR014001 |
| Ensembl Family Description |
TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX HELICASE XPB SUBUNIT EC_3.6.4.12 DNA EXCISION REPAIR ERCC 3 |
| Ensembl Family |
ENSFM00250000003539 |
| Description |
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) [Source:HGNC Symbol;Acc:3435] |
| EMBL-Bank ID |
AC110926, AY163769, CH471103, M31899, BC008820 |
| HGNC Symbol |
ERCC3 |
| Entrez Gene ID |
2071 |
| Ensembl Protein ID |
ENSP00000408901, ENSP00000390888, ENSP00000285398, ENSP00000415335, ENSP00000444796 |
| UniProt Accession |
P19447, F2Z2V4 |
| RefSeq ID |
NP_000113, NM_000122 |
| Ensembl Gene ID |
ENSG00000163161 |
| Ensembl Transcript ID |
ENST00000491292, ENST00000426778, ENST00000493187, ENST00000460485, ENST00000490062, ENST00000462306, ENST00000445889, ENST00000285398, ENST00000494464, ENST00000456257 |
| Gene-Disease Assocation |
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP B; XPB, TRICHOTHIODYSTROPHY, PHOTOSENSITIVE; TTDP |
| Design Element |
202176_at, ENST00000285398, ENST00000493187, ENST00000460485, ENST00000462306, M31899_at, ENST00000426778, ENST00000494464, ENST00000445889, 1885_at, ENST00000491292, ENST00000456257, g4557562_3p_at, ENST00000490062 |
| Search EB-eye |
ENSG00000163161
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